| Title : Watermelon: setup and validation of an in silico fragment-based approach - Di Stefano_2024_J.Enzyme.Inhib.Med.Chem_39_2356179 |
| Author(s) : Di Stefano M , Galati S , Piazza L , Gado F , Granchi C , Macchia M , Giordano A , Tuccinardi T , Poli G |
| Ref : J Enzyme Inhib Med Chem , 39 :2356179 , 2024 |
| Abstract : |
| PubMedSearch : Di Stefano_2024_J.Enzyme.Inhib.Med.Chem_39_2356179 |
| PubMedID: 38864179 |
| Title : Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors - Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| Author(s) : Di Stefano M , Masoni S , Bononi G , Poli G , Galati S , Gado F , Manzi S , Vagaggini C , Brai A , Caligiuri I , Asif K , Rizzolio F , Macchia M , Chicca A , Sodi A , Di Bussolo V , Minutolo F , Meier P , Gertsch J , Granchi C , Dreassi E , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 263 :115916 , 2023 |
| Abstract : |
| PubMedSearch : Di Stefano_2023_Eur.J.Med.Chem_263_115916 |
| PubMedID: 37976705 |
| Title : A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration - Berrino_2023_Antioxidants.(Basel)_12_ |
| Author(s) : Berrino E , Carradori S , Carta F , Melfi F , Gallorini M , Poli G , Tuccinardi T , Fernandez-Bolanos JG , Lopez O , Petzer JP , Petzer A , Guglielmi P , Secci D , Supuran CT |
| Ref : Antioxidants (Basel) , 12 : , 2023 |
| Abstract : |
| PubMedSearch : Berrino_2023_Antioxidants.(Basel)_12_ |
| PubMedID: 38136164 |
| Title : Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives - Bononi_2022_J.Med.Chem__ |
| Author(s) : Bononi G , Di Stefano M , Poli G , Ortore G , Meier P , Masetto F , Caligiuri I , Rizzolio F , Macchia M , Chicca A , Avan A , Giovannetti E , Vagaggini C , Brai A , Dreassi E , Valoti M , Minutolo F , Granchi C , Gertsch J , Tuccinardi T |
| Ref : Journal of Medicinal Chemistry , : , 2022 |
| Abstract : |
| PubMedSearch : Bononi_2022_J.Med.Chem__ |
| PubMedID: 35522977 |
| Title : Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold - Bononi_2021_Eur.J.Med.Chem_223_113679 |
| Author(s) : Bononi G , Tonarini G , Poli G , Barravecchia I , Caligiuri I , Macchia M , Rizzolio F , Demontis GC , Minutolo F , Granchi C , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 223 :113679 , 2021 |
| Abstract : |
| PubMedSearch : Bononi_2021_Eur.J.Med.Chem_223_113679 |
| PubMedID: 34218085 |
| Title : An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present) - Bononi_2021_Expert.Opin.Ther.Pat_31_153 |
| Author(s) : Bononi G , Poli G , Rizzolio F , Tuccinardi T , Macchia M , Minutolo F , Granchi C |
| Ref : Expert Opin Ther Pat , 31 :153 , 2021 |
| Abstract : |
| PubMedSearch : Bononi_2021_Expert.Opin.Ther.Pat_31_153 |
| PubMedID: 33085920 |
| Title : Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study - Jha_2020_Molecules_26_ |
| Author(s) : Jha V , Biagi M , Spinelli V , Di Stefano M , Macchia M , Minutolo F , Granchi C , Poli G , Tuccinardi T |
| Ref : Molecules , 26 : , 2020 |
| Abstract : |
| PubMedSearch : Jha_2020_Molecules_26_ |
| PubMedID: 33375358 |
| Title : Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors - Granchi_2020_Eur.J.Med.Chem_209_112857 |
| Author(s) : Granchi C , Bononi G , Ferrisi R , Gori E , Mantini G , Glasmacher S , Poli G , Palazzolo S , Caligiuri I , Rizzolio F , Canzonieri V , Perin T , Gertsch J , Sodi A , Giovannetti E , Macchia M , Minutolo F , Tuccinardi T , Chicca A |
| Ref : Eur Journal of Medicinal Chemistry , 209 :112857 , 2020 |
| Abstract : |
| PubMedSearch : Granchi_2020_Eur.J.Med.Chem_209_112857 |
| PubMedID: 33045662 |
| Gene_locus related to this paper: human-MGLL |
| Title : Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor - Granchi_2019_J.Med.Chem_62_1932 |
| Author(s) : Granchi C , Lapillo M , Glasmacher S , Bononi G , Licari C , Poli G , El Boustani M , Caligiuri I , Rizzolio F , Gertsch J , Macchia M , Minutolo F , Tuccinardi T , Chicca A |
| Ref : Journal of Medicinal Chemistry , 62 :1932 , 2019 |
| Abstract : |
| PubMedSearch : Granchi_2019_J.Med.Chem_62_1932 |
| PubMedID: 30715876 |
| Title : Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system - Gado_2019_Bioorg.Chem__103353 |
| Author(s) : Gado F , Arena C , Fauci C , Reynoso-Moreno I , Bertini S , Digiacomo M , Meini S , Poli G , Macchia M , Tuccinardi T , Gertsch J , Chicca A , Manera C |
| Ref : Bioorg Chem , :103353 , 2019 |
| Abstract : |
| PubMedSearch : Gado_2019_Bioorg.Chem__103353 |
| PubMedID: 31668465 |
| Title : Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors - Poli_2019_J.Enzyme.Inhib.Med.Chem_34_589 |
| Author(s) : Poli G , Lapillo M , Jha V , Mouawad N , Caligiuri I , Macchia M , Minutolo F , Rizzolio F , Tuccinardi T , Granchi C |
| Ref : J Enzyme Inhib Med Chem , 34 :589 , 2019 |
| Abstract : |
| PubMedSearch : Poli_2019_J.Enzyme.Inhib.Med.Chem_34_589 |
| PubMedID: 30696302 |
| Gene_locus related to this paper: human-MGLL |
| Title : Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system - Chicca_2018_Eur.J.Med.Chem_154_155 |
| Author(s) : Chicca A , Arena C , Bertini S , Gado F , Ciaglia E , Abate M , Digiacomo M , Lapillo M , Poli G , Bifulco M , Macchia M , Tuccinardi T , Gertsch J , Manera C |
| Ref : Eur Journal of Medicinal Chemistry , 154 :155 , 2018 |
| Abstract : |
| PubMedSearch : Chicca_2018_Eur.J.Med.Chem_154_155 |
| PubMedID: 29793210 |
| Title : Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors - Bononi_2018_Eur.J.Med.Chem_157_817 |
| Author(s) : Bononi G , Granchi C , Lapillo M , Giannotti M , Nieri D , Fortunato S , Boustani ME , Caligiuri I , Poli G , Carlson KE , Kim SH , Macchia M , Martinelli A , Rizzolio F , Chicca A , Katzenellenbogen JA , Minutolo F , Tuccinardi T |
| Ref : Eur Journal of Medicinal Chemistry , 157 :817 , 2018 |
| Abstract : |
| PubMedSearch : Bononi_2018_Eur.J.Med.Chem_157_817 |
| PubMedID: 30144699 |
| Title : New diterpenes from Salvia pseudorosmarinus and their activity as inhibitors of monoacylglycerol lipase (MAGL) - De Leo_2018_Fitoterapia_130_251 |
| Author(s) : De Leo M , Huallpa CG , Alvarado B , Granchi C , Poli G , De Tommasi N , Braca A |
| Ref : Fitoterapia , 130 :251 , 2018 |
| Abstract : |
| PubMedSearch : De Leo_2018_Fitoterapia_130_251 |
| PubMedID: 30240845 |
| Title : Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie - Poli_2013_Life.Sci_92_1145 |
| Author(s) : Poli G , Corda E , Martino PA , Dall'ara P , Bareggi SR , Bondiolotti G , Iulini B , Mazza M , Casalone C , Hwang SH , Hammock BD , Inceoglu B |
| Ref : Life Sciences , 92 :1145 , 2013 |
| Abstract : |
| PubMedSearch : Poli_2013_Life.Sci_92_1145 |
| PubMedID: 23651659 |