Galantamine-benzylpyridine-C2
hAChE (IC50 = 513.90 +/- 9.60 nM) and hBuChE (IC50 = 357.77 +/- 10.24 nM)
General
Type : Derivative of Galanthamine, Alkaloid, Natural_modified, Alkyl linked bis-ligand, Piperidine, Pyridine, Benzazepin, Azepane
Chemical_Nomenclature : (4aS,6R,8aS)-6-((5-(2-fluorobenzyl)pyridin-2-yl)methoxy)-3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo [2,3]benzofuro [4,3-cd]azepine
Canonical SMILES : C12=C3CN(CC|C14[C@@H](OC2=C(C=C3)OC)C[C@H](C=C4)OCC5=CC=C(C=N5)CC6=CC=CC=C6F)C
InChI : InChI=1S\/C30H29FN2O3\/c1-4-33(2)18-22-10-14-27(34-3)30-29(22)25-13-12-24(16-28(25)36-30)35-19-23-11-9-20(17-32-23)15-21-7-5-6-8-26(21)31\/h5-14,17,24,28H,4,15-16,18-19H2,2-3H3\/t24-,28-\/m0\/s1
InChIKey : ZBSREANPURJWII-CUBQBAPOSA-N
Other name(s) : Compound C2
Target
Families : Galantamine-benzylpyridine-C2 ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Design, synthesis and biological evaluation of galantamine analogues for cognitive improvement in Alzheimer's disease - Li_2024_Eur.J.Med.Chem_284_117198 |
| Author(s) : Li M , Ma C , Li Y , Wang H , Xiu X , Zhao X , Liu P , Yang H , Cheng M |
| Ref : Eur Journal of Medicinal Chemistry , 284 :117198 , 2024 |
| Abstract : |
| PubMedSearch : Li_2024_Eur.J.Med.Chem_284_117198 |
| PubMedID: 39733484 |