Ginsenosides
Prototype of numerous derived compound found in Ginseng extracts (Panax ginseng)including ( notoginsenoside R1, ginsenoside Rg1, Re, Rb1, and Rd). Dammarane type triterpene saponins based mainly on the aglycones, protopanaxadiol and protopanaxatriol. Ginsenoside RG1 CID: 441923; Re CID: 441921; Rf CID: 441922; rb1 CID: 9898279; Rc CID: 12855889; Rb2 CID: 6917976; Rg3 CID: 9918693; F2 CID: 9918692; Rh3 CID: 20839223
General
Type : Natural, Terpenoid, Phenanthrene
Chemical_Nomenclature : (3S,5R,8R,9R,10R,14R,17S)-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Canonical SMILES : CC(=CCCC(C)([C@H]1CC[C@@]2(C1CC[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)C)O)C
InChI : InChI=1S\/C30H52O2\/c1-20(2)10-9-16-30(8,32)22-13-18-28(6)21(22)11-12-24-27(5)17-15-25(31)26(3,4)23(27)14-19-29(24,28)7\/h10,21-25,31-32H,9,11-19H2,1-8H3\/t21?,22-,23-,24+,25-,27-,28+,29+,30?\/m0\/s1
InChIKey : NLHQJXWYMZLQJY-SWIZOJJJSA-N
Other name(s) : Panaxosides || Ginsenoside || 3K198YD54P || CHEBI:74978 || SCHEMBL29611594 || RefChem:143233
MW : 444.7
Formula : C30H52O2
CAS_number : 74749-74-9
PubChem : 3086007
UniChem : NLHQJXWYMZLQJY-SWIZOJJJSA-N
Target
References (26)
| Title : Ginsenoside Rg1 Promotes the Survival, Proliferation, and Differentiation of Senescent Neural Stem Cells Induced by D-galactose - Sun_2025_Actas.Esp.Psiquiatr_53_49 |
| Author(s) : Sun P , Wang S , Hu L , Huang Y , Wang Y |
| Ref : Actas Esp Psiquiatr , 53 :49 , 2025 |
| Abstract : |
| PubMedSearch : Sun_2025_Actas.Esp.Psiquiatr_53_49 |
| PubMedID: 39801411 |
| Title : Acori Tatarinowii Rhizoma regulates OCT3\/OATP2 and P-gp\/MRP1 to guide medicines upwards in Kai-Xin-San to treat Alzheimer's disease - Li_2025_J.Ethnopharmacol_343_119484 |
| Author(s) : Li J , Shan X , Gao Y , Zhu H , Cheng H , Xing C , Zhou L , Tao W , Li Y , Yin B , Zhang C |
| Ref : J Ethnopharmacol , 343 :119484 , 2025 |
| Abstract : |
| PubMedSearch : Li_2025_J.Ethnopharmacol_343_119484 |
| PubMedID: 39947370 |
| Title : Neuroprotection and Enhanced Learning and Memory Abilities of Steamed American Ginseng (Panax quinquefolium L.) Based on Zebrafish - Yang_2025_Food.Sci.Nutr_13_e70369 |
| Author(s) : Yang Y , Liang S , Xu M , Liu X , Guo Y , Gong J , Zhao L , Cai G |
| Ref : Food Sci Nutr , 13 :e70369 , 2025 |
| Abstract : |
| PubMedSearch : Yang_2025_Food.Sci.Nutr_13_e70369 |
| PubMedID: 40458084 |
| Title : Structure-activity relationship of ginsenoside derivatives with different glycosides and double bond position on anti-aging bioactivities - Zhang_2025_J.Ginseng.Res_49_553 |
| Author(s) : Zhang J , Wang W , Fan D , Deng J , Yang H |
| Ref : J Ginseng Res , 49 :553 , 2025 |
| Abstract : |
| PubMedSearch : Zhang_2025_J.Ginseng.Res_49_553 |
| PubMedID: 40843018 |
| Title : Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management Using Traditional Medicinal Plants - Tripathi_2024_Degener.Neurol.Neuromuscul.Dis_14_47 |
| Author(s) : Tripathi PN , Lodhi A , Rai SN , Nandi NK , Dumoga S , Yadav P , Tiwari AK , Singh SK , El-Shorbagi AA , Chaudhary S |
| Ref : Degener Neurol Neuromuscul Dis , 14 :47 , 2024 |
| Abstract : |
| PubMedSearch : Tripathi_2024_Degener.Neurol.Neuromuscul.Dis_14_47 |
| PubMedID: 38784601 |
| Title : Ginsenoside Rh2 Regulates the Calcium\/ROS\/CK1alpha\/MLKL Pathway to Promote Premature Eryptosis and Hemolysis in Red Blood Cells - Alghareeb_2024_Toxicol.Pathol__1926233241268846 |
| Author(s) : Alghareeb SA , Alsughayyir J , Alfhili MA |
| Ref : Toxicol Pathol , :1926233241268846 , 2024 |
| Abstract : |
| PubMedSearch : Alghareeb_2024_Toxicol.Pathol__1926233241268846 |
| PubMedID: 39148410 |
| Title : Dammarane-type Saponins from the Leaves of Vietnamese Ginseng (Panax vietnamensis Ha & Grushv.) and Their Acetylcholinesterase Inhibition In Vitro and In Silico - Nguyen_2024_Chem.Biodivers__e202401329 |
| Author(s) : Nguyen H , Vu VT , Nguyen NH , Dang HH , Pham HTT , Nguyen THA , Dang TN , Phuong TT |
| Ref : Chem Biodivers , :e202401329 , 2024 |
| Abstract : |
| PubMedSearch : Nguyen_2024_Chem.Biodivers__e202401329 |
| PubMedID: 39363736 |
| Title : Comparative study on inhibitory effects of ginsenosides on human pancreatic lipase and porcine pancreatic lipase: structure-activity relationships and inhibitory mechanism - Wang_2023_Nat.Prod.Res__1 |
| Author(s) : Wang AQ , Wang YJ , Zhang J , Fan YM , Li SY , Zou LW |
| Ref : Nat Prod Res , :1 , 2023 |
| Abstract : |
| PubMedSearch : Wang_2023_Nat.Prod.Res__1 |
| PubMedID: 37471672 |
| Title : Improvement of Cognitive Function by Fermented Panax ginseng C.A. Meyer Berries Extracts in an AF64A-Induced Memory Deficit Model - Yoon_2023_Nutrients_15_ |
| Author(s) : Yoon EJ , Ahn JW , Kim HS , Choi Y , Jeong J , Joo SS , Park D |
| Ref : Nutrients , 15 : , 2023 |
| Abstract : |
| PubMedSearch : Yoon_2023_Nutrients_15_ |
| PubMedID: 37571326 |
| Title : Research Progress on Effects of Ginsenoside Rg2 and Rh1 on Nervous System and Related Mechanisms - Liu_2023_Molecules_28_7935 |
| Author(s) : Liu S , Chen W , Zhao Y , Zong Y , Li J , He Z |
| Ref : Molecules , 28 :7935 , 2023 |
| Abstract : |
| PubMedSearch : Liu_2023_Molecules_28_7935 |
| PubMedID: 38067664 |
| Title : Dynamic changes in chemical compositions and anti-acetylcholinesterase activity associated with steaming process of stem-leaf saponins of Panax notoginseng - Ma_2021_Biomed.Chromatogr__e5077 |
| Author(s) : Ma C , Guan H , Lin Q , Liu C , Ju Z , Xue Y , Cheng X , Wang C |
| Ref : Biomedical Chromatography , :e5077 , 2021 |
| Abstract : |
| PubMedSearch : Ma_2021_Biomed.Chromatogr__e5077 |
| PubMedID: 33475178 |
| Title : Neuroprotective Effect and Antioxidant Potency of Fermented Cultured Wild Ginseng Root Extracts of Panax ginseng C.A. Meyer in Mice - Kim_2021_Molecules_26_ |
| Author(s) : Kim CJ , Ryu HY , Lee S , Lee HJ , Chun YS , Kim JK , Yu CY , Ghimire BK , Lee JG |
| Ref : Molecules , 26 : , 2021 |
| Abstract : |
| PubMedSearch : Kim_2021_Molecules_26_ |
| PubMedID: 34070099 |
| Title : Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota - Peng_2021_Phytomedicine_93_153772 |
| Author(s) : Peng X , Hao M , Zhao Y , Cai Y , Chen X , Chen H , Zhang Y , Dong L , Liu X , Ding C , Liu W , Yang M , Luo Y |
| Ref : Phytomedicine , 93 :153772 , 2021 |
| Abstract : |
| PubMedSearch : Peng_2021_Phytomedicine_93_153772 |
| PubMedID: 34753028 |
| Title : Cognitive-enhancing effects of fibrauretine on Abeta1-42-induced Alzheimer's disease by compatibilization with ginsenosides - Zhang_2020_Neuropeptides__102020 |
| Author(s) : Zhang M , Chen W , Zong Y , Shi K , Li J , Zeng F , He Z , Du R |
| Ref : Neuropeptides , :102020 , 2020 |
| Abstract : |
| PubMedSearch : Zhang_2020_Neuropeptides__102020 |
| PubMedID: 31982159 |
| Title : GAPT regulates cholinergic dysfunction and oxidative stress in the brains of learning and memory impairment mice induced by scopolamine - Liu_2020_Brain.Behav__e01602 |
| Author(s) : Liu Z , Qin G , Mana L , Dong Y , Huang S , Wang Y , Wu Y , Shi J , Tian J , Wang P |
| Ref : Brain Behav , :e01602 , 2020 |
| Abstract : |
| PubMedSearch : Liu_2020_Brain.Behav__e01602 |
| PubMedID: 32174034 |
| Title : Amino acid, fatty acid, and carbohydrate metabolomic profiles with ginsenoside-induced insecticidal efficacy against Ostrinia furnacalis (Guenee) - Liu_2020_J.Ginseng.Res_44_544 |
| Author(s) : Liu S , Wang X , Zhang R , Song M , Zhang N , Li W , Wang Y , Xu Y , Zhang L |
| Ref : J Ginseng Res , 44 :544 , 2020 |
| Abstract : |
| PubMedSearch : Liu_2020_J.Ginseng.Res_44_544 |
| PubMedID: 32617034 |
| Title : Acupuncture of the Beishu acupoint participates in regulatory effects of ginsenoside Rg1 on T cell subsets of rats with chronic fatigue syndrome - He_2020_Ann.Palliat.Med_9_3436 |
| Author(s) : He J , Yu Q , Wu C , Sun Z , Wu X , Liu R , Zhang H |
| Ref : Ann Palliat Med , 9 :3436 , 2020 |
| Abstract : |
| PubMedSearch : He_2020_Ann.Palliat.Med_9_3436 |
| PubMedID: 33065794 |
| Title : Ginsenosides Rg5 and Rk1 Enriched Cultured Wild Ginseng Root Extract Bioconversion of Pediococcus pentosaceus HLJG0702: Effect on Scopolamine-Induced Memory Dysfunction in Mice - An_2019_Nutrients_11_ |
| Author(s) : An KS , Choi YO , Lee SM , Ryu HY , Kang SJ , Yeon Y , Kim YR , Lee JG , Kim CJ , Lee YJ , Kang BJ , Choi JE , Song KS |
| Ref : Nutrients , 11 : , 2019 |
| Abstract : |
| PubMedSearch : An_2019_Nutrients_11_ |
| PubMedID: 31137483 |
| Title : Systematic exploration of Astragalus membranaceus and Panax ginseng as immune regulators: Insights from the comparative biological and computational analysis - Liu_2019_Phytomedicine__153077 |
| Author(s) : Liu J , Nile SH , Xu G , Wang Y , Kai G |
| Ref : Phytomedicine , :153077 , 2019 |
| Abstract : |
| PubMedSearch : Liu_2019_Phytomedicine__153077 |
| PubMedID: 31477352 |
| Title : Screening and determination for potential acetylcholinesterase inhibitory constituents from ginseng stem-leaf saponins using ultrafiltration (UF)-LC-ESI-MS(2) - Yang_2019_Phytochem.Anal_30_26 |
| Author(s) : Yang Y , Liang X , Jin P , Li N , Zhang Q , Yan W , Zhang H , Sun J |
| Ref : Phytochem Anal , 30 :26 , 2019 |
| Abstract : |
| PubMedSearch : Yang_2019_Phytochem.Anal_30_26 |
| PubMedID: 30159954 |
| Title : Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments - Chen_2019_J.Ginseng.Res_43_499 |
| Author(s) : Chen C , Zhang H , Xu H , Zheng Y , Wu T , Lian Y |
| Ref : J Ginseng Res , 43 :499 , 2019 |
| Abstract : |
| PubMedSearch : Chen_2019_J.Ginseng.Res_43_499 |
| PubMedID: 31695559 |
| Title : Neuroprotective effects of 20(S)-protopanaxatriol (PPT) on scopolamine-induced cognitive deficits in mice - Lu_2018_Phytother.Res_32_1056 |
| Author(s) : Lu C , Lv J , Dong L , Jiang N , Wang Y , Wang Q , Li Y , Chen S , Fan B , Wang F , Liu X |
| Ref : Phytother Res , 32 :1056 , 2018 |
| Abstract : |
| PubMedSearch : Lu_2018_Phytother.Res_32_1056 |
| PubMedID: 29468740 |
| Title : Arachidicoccus ginsenosidivorans sp. nov., with ginsenoside-converting activity isolated from ginseng cultivating soil - Siddiqi_2017_Int.J.Syst.Evol.Microbiol_67_1005 |
| Author(s) : Siddiqi MZ , Aslam Z , Im WT |
| Ref : Int J Syst Evol Microbiol , 67 :1005 , 2017 |
| Abstract : |
| PubMedSearch : Siddiqi_2017_Int.J.Syst.Evol.Microbiol_67_1005 |
| PubMedID: 27974091 |
| Gene_locus related to this paper: 9bact-a0a5b8vqb9 |
| Title : Flavisolibacter ginsenosidimutans sp. nov., with ginsenoside-converting activity isolated from soil used for cultivating ginseng - Zhao_2015_Int.J.Syst.Evol.Microbiol_65_4868 |
| Author(s) : Zhao Y , Liu Q , Kang MS , Jin F , Yu H , Im WT |
| Ref : Int J Syst Evol Microbiol , 65 :4868 , 2015 |
| Abstract : |
| PubMedSearch : Zhao_2015_Int.J.Syst.Evol.Microbiol_65_4868 |
| PubMedID: 26442990 |
| Gene_locus related to this paper: 9bact-a0a5b8uge7 |
| Title : Simultaneous enrichment of deglycosylated ginsenosides and monacolin K in red ginseng by fermentation with Monascus pilosus - Hong_2011_Biosci.Biotechnol.Biochem_75_1490 |
| Author(s) : Hong SY , Oh JH , Lee I |
| Ref : Biosci Biotechnol Biochem , 75 :1490 , 2011 |
| Abstract : |
| PubMedSearch : Hong_2011_Biosci.Biotechnol.Biochem_75_1490 |
| PubMedID: 21821946 |
| Gene_locus related to this paper: monpi-mokd |