KS12
KS12 IC 50 ACHE 1.8 nM activity against lipid peroxidation. Reduced inflammation in vivo, which can be correlated with their antioxidant activity
General
Type : Multitarget, Piperidine, Dimethoxyphenyl, Benzylpiperidine, Derivative of Donepezil, Hydroxycinnamic-ester, Sinapyl, Cinnamate, Acrylate
Chemical_Nomenclature : (E)-2-(1-benzylpiperidin-4-yl)ethyl 3-(4-hydroxy-3,5-dimethoxyphenyl) acrylate
Canonical SMILES : C1(=C(C=C(C=C1OC)C=CC(OCCC2CCN(CC2)CC3=CC=CC=C3)=O)OC)O
InChI : InChI=1S\/C25H31NO5\/c1-29-22-16-21(17-23(30-2)25(22)28)8-9-24(27)31-15-12-19-10-13-26(14-11-19)18-20-6-4-3-5-7-20\/h3-9,16-17,19,28H,10-15,18H2,1-2H3
InChIKey : MLPODEOGWNFURG-UHFFFAOYSA-N
Other name(s) :
Target
References (1)
| Title : Synthesis and Evaluation of Novel Cinnamic Acid Hybrids With Antiacetylcholinesterase, Antioxidant, and Anti-Inflammatory Properties - Sdougkou_2026_ChemMedChem_21_e70343 |
| Author(s) : Sdougkou K , Rekka E , Papagiannopoulou D |
| Ref : ChemMedChem , 21 :e70343 , 2026 |
| Abstract : |
| PubMedSearch : Sdougkou_2026_ChemMedChem_21_e70343 |
| PubMedID: 42271174 |