M30D

M30D was constructed using the key pharmacophoric moieties from rasagiline (MAOI), rivastigmine, and tacrine. The carbamyl group is cleaved by AChE to release M30D that binds to metal ions to block free radical production

General

Type : Monoamine-oxidase-inhibitor, Multitarget, Carbamate, Quinoline

Chemical_Nomenclature : [5-[[methyl(prop-2-ynyl)amino]methyl]quinolin-8-yl] N,N-dimethylcarbamate

Canonical SMILES : CN(C)C(=O)OC1=C2C(=C(C=C1)CN(C)CC#C)C=CC=N2

InChI : InChI=1S\/C17H19N3O2\/c1-5-11-20(4)12-13-8-9-15(22-17(21)19(2)3)16-14(13)7-6-10-18-16\/h1,6-10H,11-12H2,2-4H3

InChIKey : JWUFDSSCTMPGLI-UHFFFAOYSA-N

Other name(s) : Prochelators, 2  ||  SCHEMBL608520  ||  CHEMBL3407591  ||  BDBM36552


MW : 297.35

Formula : C17H19N3O2

CAS_number :

PubChem : 46863225

UniChem : JWUFDSSCTMPGLI-UHFFFAOYSA-N

Target

Families : M30D ligand of proteins in family
ACHE

Protein :
human-ACHE

References (4)

Title : New acetylcholinesterase inhibitors for Alzheimer's disease - Mehta_2012_Int.J.Alzheimers.Dis_2012_728983
Author(s) : Mehta M , Adem A , Sabbagh M
Ref : Int J Alzheimers Dis , 2012 :728983 , 2012
Abstract :
PubMedSearch : Mehta_2012_Int.J.Alzheimers.Dis_2012_728983
PubMedID: 22216416

Title : From anti-Parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer's disease - Zheng_2012_J.Alzheimers.Dis_30_1
Author(s) : Zheng H , Amit T , Bar-Am O , Fridkin M , Youdim MB , Mandel SA
Ref : J Alzheimers Dis , 30 :1 , 2012
Abstract :
PubMedSearch : Zheng_2012_J.Alzheimers.Dis_30_1
PubMedID: 22387411

Title : Site-activated chelators derived from anti-Parkinson drug rasagiline as a potential safer and more effective approach to the treatment of Alzheimer's disease - Zheng_2010_Neurochem.Res_35_2117
Author(s) : Zheng H , Fridkin M , Youdim MB
Ref : Neurochem Res , 35 :2117 , 2010
Abstract :
PubMedSearch : Zheng_2010_Neurochem.Res_35_2117
PubMedID: 20981484

Title : The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30 - Youdim_2006_Curr.Alzheimer.Res_3_541
Author(s) : Youdim MB
Ref : Curr Alzheimer Res , 3 :541 , 2006
Abstract :
PubMedSearch : Youdim_2006_Curr.Alzheimer.Res_3_541
PubMedID: 17168653