M30D
M30D was constructed using the key pharmacophoric moieties from rasagiline (MAOI), rivastigmine, and tacrine. The carbamyl group is cleaved by AChE to release M30D that binds to metal ions to block free radical production
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Carbamate, Quinoline
Chemical_Nomenclature : [5-[[methyl(prop-2-ynyl)amino]methyl]quinolin-8-yl] N,N-dimethylcarbamate
Canonical SMILES : CN(C)C(=O)OC1=C2C(=C(C=C1)CN(C)CC#C)C=CC=N2
InChI : InChI=1S\/C17H19N3O2\/c1-5-11-20(4)12-13-8-9-15(22-17(21)19(2)3)16-14(13)7-6-10-18-16\/h1,6-10H,11-12H2,2-4H3
InChIKey : JWUFDSSCTMPGLI-UHFFFAOYSA-N
Other name(s) : Prochelators, 2, SCHEMBL608520, CHEMBL3407591, BDBM36552
MW : 297.35
Formula : C17H19N3O2
CAS_number :
PubChem : 46863225
UniChem : JWUFDSSCTMPGLI-UHFFFAOYSA-N
Target
Families : M30D ligand of proteins in family
ACHE
Protein :
human-ACHE
References (4)
| Title : New acetylcholinesterase inhibitors for Alzheimer's disease - Mehta_2012_Int.J.Alzheimers.Dis_2012_728983 |
| Author(s) : Mehta M , Adem A , Sabbagh M |
| Ref : Int J Alzheimers Dis , 2012 :728983 , 2012 |
| PubMedID: 22216416 |
| Title : From anti-Parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer's disease - Zheng_2012_J.Alzheimers.Dis_30_1 |
| Author(s) : Zheng H , Amit T , Bar-Am O , Fridkin M , Youdim MB , Mandel SA |
| Ref : J Alzheimers Dis , 30 :1 , 2012 |
| PubMedID: 22387411 |
| Title : Site-activated chelators derived from anti-Parkinson drug rasagiline as a potential safer and more effective approach to the treatment of Alzheimer's disease - Zheng_2010_Neurochem.Res_35_2117 |
| Author(s) : Zheng H , Fridkin M , Youdim MB |
| Ref : Neurochem Res , 35 :2117 , 2010 |
| PubMedID: 20981484 |
| Title : The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30 - Youdim_2006_Curr.Alzheimer.Res_3_541 |
| Author(s) : Youdim MB |
| Ref : Curr Alzheimer Res , 3 :541 , 2006 |
| PubMedID: 17168653 |