MAGL-2011
IC50 5.15 nM
General
Type : Piperazine, Azetidin, Thiazolidine, Sulfur Compound, PET probe, Biphenyl
Chemical_Nomenclature : (4-(1-(3-chloro-4-fluoro-2-methyl-[1,1-biphenyl]-4-carbonyl)azetidin-3-yl)piperazin-1-yl)(thiazol-2-yl)methanone
Canonical SMILES : C1CN(CCN1C2CN(C2)C(=O)C3=CC=C(C(=C3)C)C4=CC=C(C(=C4)Cl)F)C(C5=NC=CS5)=O
InChI : InChI=1S\/C25H24ClFN4O2S\/c1-16-12-18(2-4-20(16)17-3-5-22(27)21(26)13-17)24(32)31-14-19(15-31)29-7-9-30(10-8-29)25(33)23-28-6-11-34-23\/h2-6,11-13,19H,7-10,14-15H2,1H3
InChIKey : YQJPIQIFWANMCN-UHFFFAOYSA-N
Other name(s) : Compound 3
Target
Families : MAGL-2011 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (3)
| Title : Development of a novel (18)F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography - Rong_2025_Acta.Pharm.Sin.B_15_6714 |
| Author(s) : Rong J , Zhao C , Chaudhary AF , Ware T , Van RS , Li Y , Calderon Leon ER , Dang V , Chen J , Xiao Z , Zhou X , Zhang W , Bi C , Zhang K , Patel JS , Shao Y , Ran C , Collin L , Haider A , Cravatt BF , Liang SH |
| Ref : Acta Pharm Sin B , 15 :6714 , 2025 |
| Abstract : |
| PubMedSearch : Rong_2025_Acta.Pharm.Sin.B_15_6714 |
| PubMedID: 41477323 |
| Gene_locus related to this paper: human-MGLL |
| Title : Development of a novel (18)F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography - Rong_2025_Acta.Pharm.Sin.B_15_6714 |
| Author(s) : Rong J , Zhao C , Chaudhary AF , Ware T , Van RS , Li Y , Calderon Leon ER , Dang V , Chen J , Xiao Z , Zhou X , Zhang W , Bi C , Zhang K , Patel JS , Shao Y , Ran C , Collin L , Haider A , Cravatt BF , Liang SH |
| Ref : Acta Pharm Sin B , 15 :6714 , 2025 |
| Abstract : |
| PubMedSearch : Rong_2025_Acta.Pharm.Sin.B_15_6714 |
| PubMedID: 41477323 |
| Gene_locus related to this paper: human-MGLL |
| Title : Development of a novel (18)F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography - Rong_2025_Acta.Pharm.Sin.B_15_6714 |
| Author(s) : Rong J , Zhao C , Chaudhary AF , Ware T , Van RS , Li Y , Calderon Leon ER , Dang V , Chen J , Xiao Z , Zhou X , Zhang W , Bi C , Zhang K , Patel JS , Shao Y , Ran C , Collin L , Haider A , Cravatt BF , Liang SH |
| Ref : Acta Pharm Sin B , 15 :6714 , 2025 |
| Abstract : |
| PubMedSearch : Rong_2025_Acta.Pharm.Sin.B_15_6714 |
| PubMedID: 41477323 |
| Gene_locus related to this paper: human-MGLL |