MAGL23
IC50 = 80 nM
General
Type : Piperidine
Chemical_Nomenclature : [1-(2-fluoro-5-hydroxybenzoyl)piperidin-4-yl]-(4-propan-2-ylphenyl)methanone
Canonical SMILES : CC(C)C1=CC=C(C=C1)C(=O)C2CCN(CC2)C(=O)C3=C(C=CC(=C3)O)F
InChI : InChI=1S\/C22H24FNO3\/c1-14(2)15-3-5-16(6-4-15)21(26)17-9-11-24(12-10-17)22(27)19-13-18(25)7-8-20(19)23\/h3-8,13-14,17,25H,9-12H2,1-2H3
InChIKey : WUUBZNFATQKRPH-UHFFFAOYSA-N
Other name(s) : MAGL-IN-1 || CHEMBL4536045 || (1-(2-fluoro-5-hydroxybenzoyl)piperidin-4-yl)(4-isopropylphenyl)methanone || MAGL Inhibitor Compound 23 || HY-111538
MW : 369.4
Formula : C22H24FNO3
CAS_number : 2324160-91-8
PubChem : 138319671
UniChem : WUUBZNFATQKRPH-UHFFFAOYSA-N
Target
Families : MAGL23 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (2)
| Title : A carrier free delivery system of a MAGL inhibitor is effective on ovarian cancer - Palazzolo_2024_Eur.J.Pharm.Biopharm__114397 |
| Author(s) : Palazzolo S , Saorin G , Corona G , Granchi C , Tuccinardi T , Kamensek U , Brezar SK , Cemazar M , Canzonieri V , Rizzolio F |
| Ref : Eur J Pharm Biopharm , :114397 , 2024 |
| Abstract : |
| PubMedSearch : Palazzolo_2024_Eur.J.Pharm.Biopharm__114397 |
| PubMedID: 38972466 |
| Title : Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor - Granchi_2019_J.Med.Chem_62_1932 |
| Author(s) : Granchi C , Lapillo M , Glasmacher S , Bononi G , Licari C , Poli G , El Boustani M , Caligiuri I , Rizzolio F , Gertsch J , Macchia M , Minutolo F , Tuccinardi T , Chicca A |
| Ref : Journal of Medicinal Chemistry , 62 :1932 , 2019 |
| Abstract : |
| PubMedSearch : Granchi_2019_J.Med.Chem_62_1932 |
| PubMedID: 30715876 |