MEPQ

"high-afinity phosphorylating agent used to determine the number of titrable active center serines"

General

Type : Organophosphate,Quinoline

Chemical_Nomenclature : ethoxy-methyl-(1-methylquinolin-1-ium-7-yl)oxyphosphane\;iodide

Canonical SMILES : CCOP(C)OC1=CC2=C(C=CC=[N+]2C)C=C1.[I-]

InChI : InChI=1S\/C13H17NO2P.HI\/c1-4-15-17(3)16-12-8-7-11-6-5-9-14(2)13(11)10-12\;\/h5-10H,4H2,1-3H3\;1H\/q+1\;\/p-1

InChIKey : VMZQPWQVQWJHHR-UHFFFAOYSA-M

Other name(s) : 7 methylethoxyphosphinyloxy 1-methyl-quinolinium iodide,7-((Methylethoxyphosphinyl)oxy)-1-methylquinolinium,7-(Methylethoxyphosphinyloxy)-1-methylquinolinium iodide,7-((Ethoxymethylphosphinyl)oxy)-1-methylquinolinium iodide,Quinolinium, 7-((ethoxymethylphosphinyl)oxy)-1-methyl-, (S)-,Quinolinium,7-Mepq


MW : 377.158

Formula : C13H17INO2P

CAS_number : 95230-44-7

PubChem : 124530

UniChem : VMZQPWQVQWJHHR-UHFFFAOYSA-M

IUPHAR :

Wikipedia :

Target

Families : MEPQ ligand of proteins in family: ACHE

Stucture :

Protein :

References (8)

Title : Inhibition of Drosophila acetylcholinesterase by 7-(methylethoxyphosphinyloxy)1-methyl-quinolinium iodide - Stojan_1999_Chem.Biol.Interact_119-120_147
Author(s) : Stojan J , Marcel V , Fournier D
Ref : Chemico-Biological Interactions , 119-120 :147 , 1999
Abstract : Stojan_1999_Chem.Biol.Interact_119-120_147
ESTHER : Stojan_1999_Chem.Biol.Interact_119-120_147
PubMedSearch : Stojan_1999_Chem.Biol.Interact_119-120_147
PubMedID: 10421448

Title : Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes - Ashani_1995_J.Biol.Chem_270_6370
Author(s) : Ashani Y , Radic Z , Tsigelny I , Vellom DC , Pickering NA , Quinn DM , Doctor BP , Taylor P
Ref : Journal of Biological Chemistry , 270 :6370 , 1995
Abstract : Ashani_1995_J.Biol.Chem_270_6370
ESTHER : Ashani_1995_J.Biol.Chem_270_6370
PubMedSearch : Ashani_1995_J.Biol.Chem_270_6370
PubMedID: 7890775

Title : Behavioral and pharmacological assessment of butyrylcholinesterase in rats - Genovese_1995_Pharmacol.Biochem.Behav_51_647
Author(s) : Genovese RF , Doctor BP
Ref : Pharmacology, Biochemistry & Behavior , 51 :647 , 1995
Abstract : Genovese_1995_Pharmacol.Biochem.Behav_51_647
ESTHER : Genovese_1995_Pharmacol.Biochem.Behav_51_647
PubMedSearch : Genovese_1995_Pharmacol.Biochem.Behav_51_647
PubMedID: 7675838

Title : Immunochemical characterization of anti-acetylcholinesterase inhibitory monoclonal antibodies - Gentry_1993_Chem.Biol.Interact_87_227
Author(s) : Gentry MK , Saxena A , Ashani Y , Doctor BP
Ref : Chemico-Biological Interactions , 87 :227 , 1993
Abstract : Gentry_1993_Chem.Biol.Interact_87_227
ESTHER : Gentry_1993_Chem.Biol.Interact_87_227
PubMedSearch : Gentry_1993_Chem.Biol.Interact_87_227
PubMedID: 7688272

Title : Enzymes as pretreatment drugs for organophosphate toxicity - Doctor_1991_Neurosci.Biobehav.Rev_15_123
Author(s) : Doctor BP , Raveh L , Wolfe AD , Maxwell DM , Ashani Y
Ref : Neurosci Biobehav Rev , 15 :123 , 1991
Abstract : Doctor_1991_Neurosci.Biobehav.Rev_15_123
ESTHER : Doctor_1991_Neurosci.Biobehav.Rev_15_123
PubMedSearch : Doctor_1991_Neurosci.Biobehav.Rev_15_123
PubMedID: 2052184

Title : Acetylcholinesterase prophylaxis against organophosphate poisoning. Quantitative correlation between protection and blood-enzyme level in mice - Raveh_1989_Biochem.Pharmacol_38_529
Author(s) : Raveh L , Ashani Y , Levy D , De La Hoz DM , Wolfe AD , Doctor BP
Ref : Biochemical Pharmacology , 38 :529 , 1989
Abstract : Raveh_1989_Biochem.Pharmacol_38_529
ESTHER : Raveh_1989_Biochem.Pharmacol_38_529
PubMedSearch : Raveh_1989_Biochem.Pharmacol_38_529
PubMedID: 2917010

Title : Tritium labeling of a powerful methylphosphonate inhibitor of cholinesterase: synthesis and biological applications - Balan_1988_Anal.Biochem_169_95
Author(s) : Balan A , Barness I , Simon G , Levy D , Ashani Y
Ref : Analytical Biochemistry , 169 :95 , 1988
Abstract : Balan_1988_Anal.Biochem_169_95
ESTHER : Balan_1988_Anal.Biochem_169_95
PubMedSearch : Balan_1988_Anal.Biochem_169_95
PubMedID: 88220750

Title : Synthesis and in vitro properties of a powerful quaternary methylphosphonate inhibitor of acetylcholinesterase. A new marker in blood-brain barrier research - Levy_1986_Biochem.Pharmacol_35_1079
Author(s) : Levy D , Ashani Y
Ref : Biochemical Pharmacology , 35 :1079 , 1986
Abstract : Levy_1986_Biochem.Pharmacol_35_1079
ESTHER : Levy_1986_Biochem.Pharmacol_35_1079
PubMedSearch : Levy_1986_Biochem.Pharmacol_35_1079
PubMedID: 3754444