high-afinity phosphorylating agent used to determine the number of titrable active center serines
Type : Organophosphate, Quinoline
Chemical_Nomenclature : ethoxy-methyl-(1-methylquinolin-1-ium-7-yl)oxyphosphane\;iodide
Canonical SMILES : CCOP(C)OC1=CC2=C(C=CC=[N+]2C)C=C1.[I-]
InChI : InChI=1S\/C13H17NO2P.HI\/c1-4-15-17(3)16-12-8-7-11-6-5-9-14(2)13(11)10-12\;\/h5-10H,4H2,1-3H3\;1H\/q+1\;\/p-1
InChIKey : VMZQPWQVQWJHHR-UHFFFAOYSA-M
Other name(s) : 7 methylethoxyphosphinyloxy 1-methyl-quinolinium iodide, 7-((Methylethoxyphosphinyl)oxy)-1-methylquinolinium, 7-(Methylethoxyphosphinyloxy)-1-methylquinolinium iodide, 7-((Ethoxymethylphosphinyl)oxy)-1-methylquinolinium iodide, Quinolinium, 7-((ethoxymethylphosphinyl)oxy)-1-methyl-, (S)-, Quinolinium, 7-Mepq
MW : 377.158
Formula : C13H17INO2P
CAS_number : 95230-44-7
PubChem : 124530
UniChem : VMZQPWQVQWJHHR-UHFFFAOYSA-M
Families : MEPQ ligand of proteins in family
ACHE
Title : Inhibition of Drosophila acetylcholinesterase by 7-(methylethoxyphosphinyloxy)1-methyl-quinolinium iodide - Stojan_1999_Chem.Biol.Interact_119-120_147 |
Author(s) : Stojan J , Marcel V , Fournier D |
Ref : Chemico-Biological Interactions , 119-120 :147 , 1999 |
PubMedID: 10421448 |
Title : Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes - Ashani_1995_J.Biol.Chem_270_6370 |
Author(s) : Ashani Y , Radic Z , Tsigelny I , Vellom DC , Pickering NA , Quinn DM , Doctor BP , Taylor P |
Ref : Journal of Biological Chemistry , 270 :6370 , 1995 |
PubMedID: 7890775 |
Title : Behavioral and pharmacological assessment of butyrylcholinesterase in rats - Genovese_1995_Pharmacol.Biochem.Behav_51_647 |
Author(s) : Genovese RF , Doctor BP |
Ref : Pharmacology, Biochemistry & Behavior , 51 :647 , 1995 |
PubMedID: 7675838 |
Title : Enzymes as pretreatment drugs for organophosphate toxicity - Doctor_1991_Neurosci.Biobehav.Rev_15_123 |
Author(s) : Doctor BP , Raveh L , Wolfe AD , Maxwell DM , Ashani Y |
Ref : Neurosci Biobehav Rev , 15 :123 , 1991 |
PubMedID: 2052184 |
Title : Acetylcholinesterase prophylaxis against organophosphate poisoning. Quantitative correlation between protection and blood-enzyme level in mice - Raveh_1989_Biochem.Pharmacol_38_529 |
Author(s) : Raveh L , Ashani Y , Levy D , De La Hoz DM , Wolfe AD , Doctor BP |
Ref : Biochemical Pharmacology , 38 :529 , 1989 |
PubMedID: 2917010 |
Title : Synthesis and in vitro properties of a powerful quaternary methylphosphonate inhibitor of acetylcholinesterase. A new marker in blood-brain barrier research - Levy_1986_Biochem.Pharmacol_35_1079 |
Author(s) : Levy D , Ashani Y |
Ref : Biochemical Pharmacology , 35 :1079 , 1986 |
PubMedID: 3754444 |