N-saccharinopentyl-benzylamino-cpd8b
human acetylcholinesterase inhibitor (IC50 = 33 nM) and beta amyloid aggregation inhibitor
General
Type : Alkyl linked bis-ligand, Sulfur Compound, Thiazole, Benzothiazol, Derivative of Saccharin, Multitarget, anti-Abeta-aggregation
Chemical_Nomenclature : 2-[5-(benzylamino)pentyl]-1,1-dioxo-1,2-benzothiazol-3-one
Canonical SMILES : C1=CC=C(C=C1)CNCCCCCN2C(=O)C3=CC=CC=C3S2(=O)=O
InChI : InChI=1S\/C19H22N2O3S\/c22-19-17-11-5-6-12-18(17)25(23,24)21(19)14-8-2-7-13-20-15-16-9-3-1-4-10-16\/h1,3-6,9-12,20H,2,7-8,13-15H2
InChIKey : ZGHYKEDJXGZSTQ-UHFFFAOYSA-N
Other name(s) : Compound 8b || CHEMBL3922423 || BDBM50210827
MW : 358.5
Formula : C19H22N2O3S
CAS_number :
PubChem : 134140017
UniChem : ZGHYKEDJXGZSTQ-UHFFFAOYSA-N
Target
Families : N-saccharinopentyl-benzylamino-cpd8b ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Multiple Ligands Targeting Cholinesterases and beta-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore - Szalaj_2015_Arch.Pharm.(Weinheim)_348_556 |
| Author(s) : Szalaj N , Bajda M , Dudek K , Brus B , Gobec S , Malawska B |
| Ref : Arch Pharm (Weinheim) , 348 :556 , 2015 |
| Abstract : |
| PubMedSearch : Szalaj_2015_Arch.Pharm.(Weinheim)_348_556 |
| PubMedID: 26032855 |