NMDA-BCHE-C-2h
Memantine Tetrahydrocarbazol conjugate: inhibit BChE (without noticeable suppression of the AChE activity) and block the ifenprodil-binding site of NMDA receptors containing NR2B subunits. AChE inhibition % at 20microM >20 (8.8%); BChE IC50 (microM) +/-SEM 5.43 +/- 0.39; Carboxylesterase inhibition % at 20microM >20 (16.5%)
General
Type : Multitarget, NMDA-Ligand, Carbazol, Adamantyl
Chemical_Nomenclature :
Canonical SMILES : CC13CC2CC(C1)(CC(C2)(C3)NCC(C[N]5C4=C(CCCC4)C6=C5C=CC(=C6)F)O)C
InChI : InChI=1S\/C27H37FN2O\/c1-25-10-18-11-26(2,15-25)17-27(12-18,16-25)29-13-20(31)14-30-23-6-4-3-5-21(23)22-9-19(28)7-8-24(22)30\/h7-9,18,20,29,31H,3-6,10-17H2,1-2H3
InChIKey : JSYAQHFJGTVUOE-UHFFFAOYSA-N
Other name(s) :
Target
Families : NMDA-BCHE-C-2h ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment - Bachurin_2017_Sci.Rep_7_45627 |
| Author(s) : Bachurin SO , Shevtsova EF , Makhaeva GF , Grigoriev VV , Boltneva NP , Kovaleva NV , Lushchekina SV , Shevtsov PN , Neganova ME , Redkozubova OM , Bovina EV , Gabrelyan AV , Fisenko VP , Sokolov VB , Aksinenko AY , Echeverria V , Barreto GE , Aliev G |
| Ref : Sci Rep , 7 :45627 , 2017 |
| Abstract : |
| PubMedSearch : Bachurin_2017_Sci.Rep_7_45627 |
| PubMedID: 28358144 |