| Title : Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease - Makhaeva_2024_Molecules_29_321 |
| Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Lushchekina SV , Astakhova TY , Timokhina EN , Serkov IV , Proshin AN , Soldatova YV , Poletaeva DA , Faingold, II , Mumyatova VA , Terentiev AA , Radchenko EV , Palyulin VA , Bachurin SO , Richardson RJ |
| Ref : Molecules , 29 :321 , 2024 |
| Abstract : |
| PubMedSearch : Makhaeva_2024_Molecules_29_321 |
| PubMedID: 38257233 |
| Title : Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit beta-amyloid self-aggregation: potential therapeutic agents for Alzheimer's disease - Makhaeva_2023_Front.Pharmacol_14_1219980 |
| Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Lushchekina SV , Astakhova TY , Timokhina EN , Serebryakova OG , Shchepochkin AV , Averkov MA , Utepova IA , Demina NS , Radchenko EV , Palyulin VA , Fisenko VP , Bachurin SO , Chupakhin ON , Charushin VN , Richardson RJ |
| Ref : Front Pharmacol , 14 :1219980 , 2023 |
| Abstract : |
| PubMedSearch : Makhaeva_2023_Front.Pharmacol_14_1219980 |
| PubMedID: 37654616 |
| Title : Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease - Makhaeva_2023_Int.J.Mol.Sci_24_2285 |
| Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Grishchenko MV , Lushchekina SV , Astakhova TY , Serebryakova OG , Timokhina EN , Zhilina EF , Shchegolkov EV , Ulitko MV , Radchenko EV , Palyulin VA , Burgart YV , Saloutin VI , Bachurin SO , Richardson RJ |
| Ref : Int J Mol Sci , 24 :2285 , 2023 |
| Abstract : |
| PubMedSearch : Makhaeva_2023_Int.J.Mol.Sci_24_2285 |
| PubMedID: 36768608 |
| Title : Mitochondria and Oxidative Stress as a Link between Alzheimer's Disease and Diabetes Mellitus - Veselov_2023_Int.J.Mol.Sci_24_ |
| Author(s) : Veselov IM , Vinogradova DV , Maltsev AV , Shevtsov PN , Spirkova EA , Bachurin SO , Shevtsova EF |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : |
| PubMedSearch : Veselov_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 37833898 |
| Title : Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease - Bachurin_2022_Int.J.Mol.Sci_23_ |
| Author(s) : Bachurin SO , Shevtsova EF , Makhaeva GF , Aksinenko AY , Grigoriev VV , Goreva TV , Epishina TA , Kovaleva NV , Boltneva NP , Lushchekina SV , Rudakova EV , Vinogradova DV , Shevtsov PN , Pushkareva EA , Dubova LG , Serkova TP , Veselov IM , Fisenko VP , Richardson RJ |
| Ref : Int J Mol Sci , 23 : , 2022 |
| Abstract : |
| PubMedSearch : Bachurin_2022_Int.J.Mol.Sci_23_ |
| PubMedID: 36430413 |
| Title : Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile - Makhaeva_2022_Molecules_27_ |
| Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Rudakova EV , Lushchekina SV , Astakhova TY , Serkov IV , Proshin AN , Radchenko EV , Palyulin VA , Korabecny J , Soukup O , Bachurin SO , Richardson RJ |
| Ref : Molecules , 27 : , 2022 |
| Abstract : |
| PubMedSearch : Makhaeva_2022_Molecules_27_ |
| PubMedID: 35164325 |
| Title : Conjugation of Aminoadamantane and gamma-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands - Bachurin_2021_Molecules_26_ |
| Author(s) : Bachurin SO , Makhaeva GF , Shevtsova EF , Aksinenko AY , Grigoriev VV , Shevtsov PN , Goreva TV , Epishina TA , Kovaleva NV , Pushkareva EA , Boltneva NP , Lushchekina SV , Gabrelyan AV , Zamoyski VL , Dubova LG , Rudakova EV , Fisenko VP , Bovina EV , Richardson RJ |
| Ref : Molecules , 26 : , 2021 |
| Abstract : |
| PubMedSearch : Bachurin_2021_Molecules_26_ |
| PubMedID: 34576998 |
| Title : Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold - Makhaeva_2021_Eur.J.Med.Chem_218_113385 |
| Author(s) : Makhaeva GF , Lushchekina SV , Boltneva NP , Serebryakova OG , Kovaleva NV , Rudakova EV , Elkina NA , Shchegolkov EV , Burgart YV , Stupina TS , Terentiev AA , Radchenko EV , Palyulin VA , Saloutin VI , Bachurin SO , Richardson RJ |
| Ref : Eur Journal of Medicinal Chemistry , 218 :113385 , 2021 |
| Abstract : |
| PubMedSearch : Makhaeva_2021_Eur.J.Med.Chem_218_113385 |
| PubMedID: 33831780 |
| Title : New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment - Makhaeva_2020_Molecules_25_3915 |
| Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Lushchekina SV , Astakhova TY , Rudakova EV , Proshin AN , Serkov IV , Radchenko EV , Palyulin VA , Bachurin SO , Richardson RJ |
| Ref : Molecules , 25 :3915 , 2020 |
| Abstract : |
| PubMedSearch : Makhaeva_2020_Molecules_25_3915 |
| PubMedID: 32867324 |
| Title : Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers - Khudina_2019_Bioorg.Med.Chem.Lett__126716 |
| Author(s) : Khudina OG , Makhaeva GF , Elkina NA , Boltneva NP , Serebryakova OG , Shchegolkov EV , Rudakova EV , Lushchekina SV , Burgart YV , Bachurin SO , Richardson RJ , Saloutin VI |
| Ref : Bioorganic & Medicinal Chemistry Lett , :126716 , 2019 |
| Abstract : |
| PubMedSearch : Khudina_2019_Bioorg.Med.Chem.Lett__126716 |
| PubMedID: 31640885 |
| Title : Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation - Makhaeva_2019_Bioorg.Chem__103387 |
| Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Lushchekina SV , Rudakova EV , Stupina TS , Terentiev AA , Serkov IV , Proshin AN , Radchenko EV , Palyulin VV , Bachurin SO , Richardson RJ |
| Ref : Bioorg Chem , :103387 , 2019 |
| Abstract : |
| PubMedSearch : Makhaeva_2019_Bioorg.Chem__103387 |
| PubMedID: 31735356 |
| Title : Anticholinesterase and Antioxidant Activity of New Binary Conjugates of gamma-Carbolines - Makhaeva_2019_Dokl.Biochem.Biophys_484_1 |
| Author(s) : Makhaeva GF , Shevtsova EF , Boltneva NP , Kovaleva NV , Rudakova EV , Dubova LG , Shevtsov PN , Bachurin SO |
| Ref : Dokl Biochem Biophys , 484 :1 , 2019 |
| Abstract : |
| PubMedSearch : Makhaeva_2019_Dokl.Biochem.Biophys_484_1 |
| PubMedID: 31012000 |
| Title : Synthesis, molecular docking, and biological evaluation of 3-oxo-2-tolylhydrazinylidene-4,4,4-trifluorobutanoates bearing higher and natural alcohol moieties as new selective carboxylesterase inhibitors - Makhaeva_2019_Bioorg.Chem_91_103097 |
| Author(s) : Makhaeva GF , Elkina NA , Shchegolkov EV , Boltneva NP , Lushchekina SV , Serebryakova OG , Rudakova EV , Kovaleva NV , Radchenko EV , Palyulin VA , Burgart YV , Saloutin VI , Bachurin SO , Richardson RJ |
| Ref : Bioorg Chem , 91 :103097 , 2019 |
| Abstract : |
| PubMedSearch : Makhaeva_2019_Bioorg.Chem_91_103097 |
| PubMedID: 31323527 |
| Title : Conjugates of methylene blue with gamma-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases - Bachurin_2019_Sci.Rep_9_4873 |
| Author(s) : Bachurin SO , Makhaeva GF , Shevtsova EF , Boltneva NP , Kovaleva NV , Lushchekina SV , Rudakova EV , Dubova LG , Vinogradova DV , Sokolov VB , Aksinenko AY , Fisenko VP , Richardson RJ , Aliev G |
| Ref : Sci Rep , 9 :4873 , 2019 |
| Abstract : |
| PubMedSearch : Bachurin_2019_Sci.Rep_9_4873 |
| PubMedID: 30890752 |
| Title : Overview of novel multifunctional agents based on conjugates of gamma-carbolines, carbazoles, tetrahydrocarbazoles, phenothiazines, and aminoadamantanes for treatment of Alzheimer's disease - Makhaeva_2019_Chem.Biol.Interact_13ChEPon_308_224 |
| Author(s) : Makhaeva GF , Shevtsova EF , Boltneva NP , Lushchekina SV , Kovaleva NV , Rudakova EV , Bachurin SO , Richardson RJ |
| Ref : Chemico-Biological Interactions , 308 :224 , 2019 |
| Abstract : |
| PubMedSearch : Makhaeva_2019_Chem.Biol.Interact_13ChEPon_308_224 |
| PubMedID: 31100279 |
| Title : Conjugates of Tacrine and Its Cyclic Homologues with p-Toluenesulfonamide as Novel Acetylcholinesterase and Butyrylcholinesterase Inhibitors - Makhaeva_2018_Dokl.Biochem.Biophys_483_369 |
| Author(s) : Makhaeva GF , Kovaleva NV , Lushchekina SV , Rudakova EV , Boltneva NP , Proshin AN , Lednev BV , Serkov IV , Bachurin SO |
| Ref : Dokl Biochem Biophys , 483 :369 , 2018 |
| Abstract : |
| PubMedSearch : Makhaeva_2018_Dokl.Biochem.Biophys_483_369 |
| PubMedID: 30607741 |
| Title : Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment - Bachurin_2017_Sci.Rep_7_45627 |
| Author(s) : Bachurin SO , Shevtsova EF , Makhaeva GF , Grigoriev VV , Boltneva NP , Kovaleva NV , Lushchekina SV , Shevtsov PN , Neganova ME , Redkozubova OM , Bovina EV , Gabrelyan AV , Fisenko VP , Sokolov VB , Aksinenko AY , Echeverria V , Barreto GE , Aliev G |
| Ref : Sci Rep , 7 :45627 , 2017 |
| Abstract : |
| PubMedSearch : Bachurin_2017_Sci.Rep_7_45627 |
| PubMedID: 28358144 |
| Title : 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment - Makhaeva_2017_Bioorg.Med.Chem_25_5981 |
| Author(s) : Makhaeva GF , Lushchekina SV , Boltneva NP , Serebryakova OG , Rudakova EV , Ustyugov AA , Bachurin SO , Shchepochkin AV , Chupakhin ON , Charushin VN , Richardson RJ |
| Ref : Bioorganic & Medicinal Chemistry , 25 :5981 , 2017 |
| Abstract : |
| PubMedSearch : Makhaeva_2017_Bioorg.Med.Chem_25_5981 |
| PubMedID: 28986116 |
| Title : Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors - Shchegol'kov_2017_Bioorg.Med.Chem_25_3997 |
| Author(s) : Shchegol'kov EV , Makhaeva GF , Boltneva NP , Lushchekina SV , Serebryakova OG , Rudakova EV , Kovaleva NV , Burgart YV , Saloutin VI , Chupakhin ON , Bachurin SO , Richardson RJ |
| Ref : Bioorganic & Medicinal Chemistry , 25 :3997 , 2017 |
| Abstract : |
| PubMedSearch : Shchegol'kov_2017_Bioorg.Med.Chem_25_3997 |
| PubMedID: 28578994 |
| Title : Novel conjugates of tacrine with 1,2,4,-thiadiazole as highly effective cholinesterase inhibitors, blockers of NMDA receptors, and antioxidants - Makhaeva_2017_Dokl.Biochem.Biophys_477_405 |
| Author(s) : Makhaeva GF , Grigoriev VV , Proshin AN , Kovaleva NV , Rudakova EV , Boltneva NP , Serkov IV , Bachurin SO |
| Ref : Dokl Biochem Biophys , 477 :405 , 2017 |
| Abstract : |
| PubMedSearch : Makhaeva_2017_Dokl.Biochem.Biophys_477_405 |
| PubMedID: 29297118 |
| Title : Esterase profiles of organophosphorus compounds in vitro predict their behavior in vivo - Makhaeva_2016_Chem.Biol.Interact_259_332 |
| Author(s) : Makhaeva GF , Rudakova EV , Serebryakova OG , Aksinenko AY , Lushchekina SV , Bachurin SO , Richardson RJ |
| Ref : Chemico-Biological Interactions , 259 :332 , 2016 |
| Abstract : |
| PubMedSearch : Makhaeva_2016_Chem.Biol.Interact_259_332 |
| PubMedID: 27154493 |
| Title : Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile - Strelnik_2016_Bioorg.Med.Chem.Lett_26_4092 |
| Author(s) : Strelnik AD , Petukhov AS , Zueva IV , Zobov VV , Petrov KA , Nikolsky EE , Balakin KV , Bachurin SO , Shtyrlin YG |
| Ref : Bioorganic & Medicinal Chemistry Lett , 26 :4092 , 2016 |
| Abstract : |
| PubMedSearch : Strelnik_2016_Bioorg.Med.Chem.Lett_26_4092 |
| PubMedID: 27377327 |
| Title : Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors - Makhaeva_2016_Bioorg.Med.Chem_24_1050 |
| Author(s) : Makhaeva GF , Boltneva NP , Lushchekina SV , Serebryakova OG , Stupina TS , Terentiev AA , Serkov IV , Proshin AN , Bachurin SO , Richardson RJ |
| Ref : Bioorganic & Medicinal Chemistry , 24 :1050 , 2016 |
| Abstract : |
| PubMedSearch : Makhaeva_2016_Bioorg.Med.Chem_24_1050 |
| PubMedID: 26827140 |
| Title : Conjugates of gamma-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer Disease - Makhaeva_2015_Sci.Rep_5_13164 |
| Author(s) : Makhaeva GF , Lushchekina SV , Boltneva NP , Sokolov VB , Grigoriev VV , Serebryakova OG , Vikhareva EA , Aksinenko AY , Barreto GE , Aliev G , Bachurin SO |
| Ref : Sci Rep , 5 :13164 , 2015 |
| Abstract : |
| PubMedSearch : Makhaeva_2015_Sci.Rep_5_13164 |
| PubMedID: 26281952 |
| Title : N,N-disubstituted 2-aminothiazolines as new inhibitors of serine esterases - |
| Author(s) : Boltneva NP , Serebryakova OG , Makhaeva GF , Serkov IV , Proshin AN , Bachurin SO |
| Ref : Dokl Biochem Biophys , 451 :209 , 2013 |
| PubMedID: 23975403 |
| Title : Effect of delta sleep inducing peptide on NMDA and GABA evoked ion currents in cortical, cerebellar and hippocampal neurons - |
| Author(s) : Grigoriev VV , Redkozubov AE , Kustova EA , Ivanova TA , Bachurin SO |
| Ref : Journal de Physiologie (Paris) , 99 :255 , 2006 |
| PubMedID: |
| Title : Mitochondria as a target for neurotoxins and neuroprotective agents - Bachurin_2003_Ann.N.Y.Acad.Sci_993_334 |
| Author(s) : Bachurin SO , Shevtsova EP , Kireeva EG , Oxenkrug GF , Sablin SO |
| Ref : Annals of the New York Academy of Sciences , 993 :334 , 2003 |
| Abstract : |
| PubMedSearch : Bachurin_2003_Ann.N.Y.Acad.Sci_993_334 |
| PubMedID: 12853325 |
| Title : Dimebon improves learning in animals with experimental Alzheimer's disease - Lermontova_2000_Bull.Exp.Biol.Med_129_544 |
| Author(s) : Lermontova NN , Lukoyanov NV , Serkova TP , Lukoyanova EA , Bachurin SO |
| Ref : Bulletin of Experimental Biology & Medicine , 129 :544 , 2000 |
| Abstract : |
| PubMedSearch : Lermontova_2000_Bull.Exp.Biol.Med_129_544 |
| PubMedID: 11022244 |