Oxoimidazolidin-trifluoromethyl-thiazole-5-carboxamide-Cpd50
human SeH IC50 0.46 nM
General
Type : Imidazole, Trifluoro, Thiazole, Carboxamide, Sulfur Compound
Chemical_Nomenclature : 2-(3-(3-chlorobenzyl)-2-oxoimidazolidin-1-yl)-N-(4-methoxy-2-(trifluoromethyl)benzyl)thiazole-5-carboxamide
Canonical SMILES : C1(=CC=CC(=C1)CN2CCN(C2=O)C3=NC=C(S3)C(NCC4=C(C=C(C=C4)OC)C(F)(F)F)=O)Cl
InChI : 1S\/C23H20ClF3N4O3S\/c1-34-17-6-5-15(18(10-17)23(25,26)27)11-28-20(32)19-12-29-21(35-19)31-8-7-30(22(31)33)13-14-3-2-4-16(24)9-14\/h2-6,9-10,12H,7-8,11,13H2,1H3,(H,28,32)
InChIKey : MSNPFXQUQIURLS-UHFFFAOYSA-N
Other name(s) : Compound 50
MW : 524.944\
Formula : C23H20ClF3N4O3S
CAS_number :
PubChem :
UniChem : MSNPFXQUQIURLS-UHFFFAOYSA-N
Target
Families : Oxoimidazolidin-trifluoromethyl-thiazole-5-carboxamide-Cpd50 ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (1)
| Title : Potent soluble epoxide hydrolase inhibitors based on thiazole-5-carboxamide structure with imidazolidinone moiety as a secondary pharmacophore - Lengerli_2025_Bioorg.Chem_163_108644 |
| Author(s) : Lengerli D , Koc B , Jordan PM , Caliskan K , Caliskan B , Werz O , Banoglu E |
| Ref : Bioorg Chem , 163 :108644 , 2025 |
| Abstract : |
| PubMedSearch : Lengerli_2025_Bioorg.Chem_163_108644 |
| PubMedID: 40466300 |