Peganine
Derivative of Desoxypeganine from plants of the Zygophyllaceae family. Inhibits both cholinesterases and monoamine oxydases. CID 442929 CID 197084 Linarine hydrochloride CID 667496 Vasicin [German] There is ambiguity in the name linearine which can design 2 different compounds
General
Type : Not AlphaBeta Hydrolase target, beta-carboline, Natural, Alkaloid, Natural_modified
Chemical_Nomenclature : (R)-1,2,3,9-Tetrahydropyrrolo(2,1-b)quinazolin-3-ol Pyrrolo(2,1-b)quinazolin-3-ol, 1,2,3,9-tetrahydro-
Canonical SMILES : C1CN2CC3=CC=CC=C3N=C2C1O || C1CN2CC3=CC=CC=C3N=C2C1O.Cl
InChI : InChI=1S\/C11H12N2O\/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13\/h1-4,10,14H,5-7H2\/t10-\/m0\/s1 || InChI=1S\/C11H12N2O.ClH\/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13\;\/h1-4,10,14H,5-7H2\;1H\/t10-\;\/m0.\/s1 || InChI=1S\/C11H12N2O\/c14-10-5-6-13-7-8-3-1-2-4-9(8)12-11(10)13\/h1-4,10,14H,5-7H2\/t10-\/m1\/s1
InChIKey : YIICVSCAKJMMDJ-JTQLQIEISA-N || CSDQSAHJCAKJPT-PPHPATTJSA-N || YIICVSCAKJMMDJ-SNVBAGLBSA-N
Other name(s) : Vasicine || ZINC00525717 || Linarine hydrochloride || (3R)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol || CHEBI:7949 || CHEMBL1456364
MW : 188
Formula : C11H12N2O
CAS_number : 6159-55-3, 18549-38-7
PubChem : 442929, 197084, 667496
UniChem : YIICVSCAKJMMDJ-JTQLQIEISA-N, CSDQSAHJCAKJPT-PPHPATTJSA-N, YIICVSCAKJMMDJ-SNVBAGLBSA-N
Wikipedia : Vasicine
References (6)
| Title : Molecular insights into vasicine and butyrylcholinesterase interactions: A complimentary biophysical, multi-spectroscopic, and computational study - Wang_2024_Int.J.Biol.Macromol__139253 |
| Author(s) : Wang N , Liu Y , Yang C , Du J , Yu D , He P , Xu H , Li L , Zhao P , Li Y |
| Ref : Int J Biol Macromol , :139253 , 2024 |
| Abstract : |
| PubMedSearch : Wang_2024_Int.J.Biol.Macromol__139253 |
| PubMedID: 39733876 |
| Title : Stereoselective glucuronidation metabolism, pharmacokinetics, anti-amnesic pharmacodynamics, and toxic properties of vasicine enantiomers in vitro and in vivo - Zhu_2018_Eur.J.Pharm.Sci_123_459 |
| Author(s) : Zhu Y , Liu W , Qi S , Wang H , Wang Y , Deng G , Zhang Y , Li S , Ma C , Cheng X , Wang C |
| Ref : Eur J Pharm Sci , 123 :459 , 2018 |
| Abstract : |
| PubMedSearch : Zhu_2018_Eur.J.Pharm.Sci_123_459 |
| PubMedID: 30077712 |
| Title : In vitro and in vivo metabolism and inhibitory activities of vasicine, a potent acetylcholinesterase and butyrylcholinesterase inhibitor - Liu_2015_PLoS.One_10_e0122366 |
| Author(s) : Liu W , Shi X , Yang Y , Cheng X , Liu Q , Han H , Yang B , He C , Wang Y , Jiang B , Wang Z , Wang C |
| Ref : PLoS ONE , 10 :e0122366 , 2015 |
| Abstract : |
| PubMedSearch : Liu_2015_PLoS.One_10_e0122366 |
| PubMedID: 25849329 |
| Title : Potent AChE and BChE inhibitors isolated from seeds of Peganum harmala Linn by a bioassay-guided fractionation - Yang_2015_J.Ethnopharmacol_168_279 |
| Author(s) : Yang Y , Cheng X , Liu W , Chou G , Wang Z , Wang C |
| Ref : J Ethnopharmacol , 168 :279 , 2015 |
| Abstract : |
| PubMedSearch : Yang_2015_J.Ethnopharmacol_168_279 |
| PubMedID: 25862961 |
| Title : Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay - Zheng_2009_Arch.Pharm.Res_32_1245 |
| Author(s) : Zheng XY , Zhang ZJ , Chou GX , Wu T , Cheng XM , Wang CH , Wang ZT |
| Ref : Arch Pharm Res , 32 :1245 , 2009 |
| Abstract : |
| PubMedSearch : Zheng_2009_Arch.Pharm.Res_32_1245 |
| PubMedID: 19784581 |
| Title : [Pharmacological characteristics of desoxypeganine hydrochloride] - Tuliaganov_1986_Farmakol.Toksikol_49_37 |
| Author(s) : Tuliaganov N , Sadritdinov FS , Suleimanova GA |
| Ref : Farmakologiia i Toksikologiia , 49 :37 , 1986 |
| Abstract : |
| PubMedSearch : Tuliaganov_1986_Farmakol.Toksikol_49_37 |
| PubMedID: 3720932 |