RS67333
RS67333 is a partial serotonin subtype 4 receptor (5-HT4R) agonist which promotes the nonamyloidogenic cleavage of the precursor of the neurotoxic amyloid-beta peptide and leads to the secretion of the neurotrophic protein sAPPalpha. RS67333 is also a submicromolar acetylcholinesterase (AChE) inhibitor. Rs67333 hydrochloride CID 129847503 UJCQKTBDTPAFRZ-UHFFFAOYSA-N
General
Type : Multitarget, 5-HT-receptor-ligand, Piperidine
Chemical_Nomenclature : 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one
Canonical SMILES : CCCCN1CCC(CC1)CCC(=O)C2=CC(=C(C=C2OC)N)Cl
InChI : InChI=1S\/C19H29ClN2O2\/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2\/h12-14H,3-11,21H2,1-2H3
InChIKey : JBHLYIVFFLNISJ-UHFFFAOYSA-N
Other name(s) : RS 67333 || RS-67333 || 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-1-propanone || Tocris-0989
MW : 352.90
Formula : C19H29ClN2O2
CAS_number : 160845-95-4
PubChem : 183782
UniChem : JBHLYIVFFLNISJ-UHFFFAOYSA-N
Target
Families : RS67333 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (2)
| Title : Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease - Toublet_2019_Molecules_24_ |
| Author(s) : Toublet FX , Lecoutey C , Lalut J , Hatat B , Davis A , Since M , Corvaisier S , Freret T , Sopkova de Oliveira Santos J , Claeysen S , Boulouard M , Dallemagne P , Rochais C |
| Ref : Molecules , 24 : , 2019 |
| Abstract : |
| PubMedSearch : Toublet_2019_Molecules_24_ |
| PubMedID: 31370232 |
| Title : Design of donecopride, a dual serotonin subtype 4 receptor agonist\/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment - Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
| Author(s) : Lecoutey C , Hedou D , Freret T , Giannoni P , Gaven F , Since M , Bouet V , Ballandonne C , Corvaisier S , Malzert Freon A , Mignani S , Cresteil T , Boulouard M , Claeysen S , Rochais C , Dallemagne P |
| Ref : Proc Natl Acad Sci U S A , 111 :E3825 , 2014 |
| Abstract : |
| PubMedSearch : Lecoutey_2014_Proc.Natl.Acad.Sci.U.S.A_111_E3825 |
| PubMedID: 25157130 |