SB-1436
inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC50s of 0.176, 0.37 and 0.08 microM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with Kis of 0.046 and 0.115 microM, respectively. SB-1436 significantly stops the self-aggregation of Abeta
General
Type : Pyridine, Naphthalen, Pyridinium, anti-Abeta-aggregation
Chemical_Nomenclature : 1-[(4-fluorophenyl)methyl]-4-[(E)-2-(6-methoxynaphthalen-2-yl)ethenyl]pyridin-1-ium
Canonical SMILES : COC1=CC2=C(C=C1)C=C(C=C2)C=CC3=CC=[N+](C=C3)CC4=CC=C(C=C4)F || COC1=CC2=C(C=C1)C=C(C=C2)C=CC3=CC=[N+](C=C3)CC4=CC=C(C=C4)F.[Cl-]
InChI : InChI=1S\/C25H21FNO\/c1-28-25-11-8-22-16-20(4-7-23(22)17-25)3-2-19-12-14-27(15-13-19)18-21-5-9-24(26)10-6-21\/h2-17H,18H2,1H3\/q+1\/b3-2+ || InChI=1S\/C25H21FNO.ClH\/c1-28-25-11-8-22-16-20(4-7-23(22)17-25)3-2-19-12-14-27(15-13-19)18-21-5-9-24(26)10-6-21\;\/h2-17H,18H2,1H3\;1H\/q+1\;\/p-1\/b3-2+\;
InChIKey : WFMBYAHNWODWSK-NSCUHMNNSA-N || RYNIKEKCSJMRGO-SQQVDAMQSA-M
Other name(s) : 7av
MW : 405.9
Formula : C25H21ClFNO || C25H21FNO+
CAS_number : 2925298-08-2'
PubChem : 170901545, 170901546
UniChem : WFMBYAHNWODWSK-NSCUHMNNSA-N, RYNIKEKCSJMRGO-SQQVDAMQSA-M
Target
Families : SB-1436 ligand of proteins in family
BCHE
ACHE
Protein :
human-BCHE
human-ACHE
References (1)
| Title : Methoxy-naphthyl-Linked N-Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship - Abdullaha_2023_ACS.Omega_8_17591 |
| Author(s) : Abdullaha M , Banoo R , Nuthakki VK , Sharma M , Kaur S , Thakur S , Kumar A , Jadhav HR , Bharate SB |
| Ref : ACS Omega , 8 :17591 , 2023 |
| Abstract : |
| PubMedSearch : Abdullaha_2023_ACS.Omega_8_17591 |
| PubMedID: 37251153 |