Salicylic-donepezil-rivastigmine-5a
Compound 5a: IC50 EelACHE 7.8 +/- 0.36 microM; eqBCHE 0.53 +/6 0.01 microM
General
Type : Carbamate, Derivative of Donepezil, Salicylic, Derivative of Rivastigmine
Chemical_Nomenclature : 4-(4-Benzylpiperidine-1-carbonyl)-1,3-phenylene bis(dimethylcarbamate)
Canonical SMILES : C1=C(C=CC(=C1OC(=O)N(C)C)C(N2CCC(CC2)CC3=CC=CC=C3)=O)OC(N(C)C)=O
InChI : InChI=1S\/C25H31N3O5\/c1-26(2)24(30)32-20-10-11-21(22(17-20)33-25(31)27(3)4)23(29)28-14-12-19(13-15-28)16-18-8-6-5-7-9-18\/h5-11,17,19H,12-16H2,1-4H3
InChIKey : QPQGKDMRJRKUGS-UHFFFAOYSA-N
Other name(s) :
Target
Families : Salicylic-donepezil-rivastigmine-5a ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Development of novel salicylic acid-donepezil-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease - Zhou_2023_J.Enzyme.Inhib.Med.Chem_38_2231661 |
| Author(s) : Zhou Y , He Y , Teng X , Mi J , Yang J , Wei R , Liu W , Ma Q , Tan Z , Sang Z |
| Ref : J Enzyme Inhib Med Chem , 38 :2231661 , 2023 |
| Abstract : |
| PubMedSearch : Zhou_2023_J.Enzyme.Inhib.Med.Chem_38_2231661 |
| PubMedID: 37414563 |