Sigma1R-BCHE-Cpd7c
IC50 BChE 37 nM (7.4 +/- 0.02); IC50 AChE 201 nM (6.6 +/- 0.09); Sigma1R 82% inhibition at 100 nM; IC50 Sigma1R 19 nM (7.7 +/- 0.05)
General
Type : Multitarget, Sigma1R ligand, Azetidin, Carbamate, Indole, Isoindole
Chemical_Nomenclature : 4-(Isoindolin-2-ylmethyl)phenyl azetidine-1-carboxylate
Canonical SMILES : N4(CC1=CC=C(C=C1)OC(=O)N2CCC2)CC3=CC=CC=C3C4
InChI : InChI=1S\/C19H20N2O2\/c22-19(21-10-3-11-21)23-18-8-6-15(7-9-18)12-20-13-16-4-1-2-5-17(16)14-20\/h1-2,4-9H,3,10-14H2
InChIKey : PTDZHNWUIGWXOI-UHFFFAOYSA-N
Other name(s) : Compound 7c
Target
Families : Sigma1R-BCHE-Cpd7c ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Targeting Neuroinflammation by Activation of the Sigma-1 Receptor (S1R) and Inhibition of Butyrylcholinesterase (hBChE) Leads to Highly Potent Anti-Amnesic Compounds in an Alzheimers Disease Mouse Model - Reichau_2026_J.Med.Chem_305_118486 |
| Author(s) : Reichau K , Crouzier L , Gehrig T , Flake A , Schaller E , Meunier J , Bertrand-Gaday C , Chatonnet A , Zvejniece L , Sotriffer C , Maurice T , Decker M |
| Ref : Journal of Medicinal Chemistry , 305 :118486 , 2025 |
| Abstract : |
| PubMedSearch : Reichau_2026_J.Med.Chem_305_118486 |
| PubMedID: 41547241 |