TAC-BIM-11d
IC50 eleelACHE 6.3 nM
General
Type : Derivative of Tacrine, Acridine, Benzimidazole, Carboxamide, Multitarget, anti-Abeta-aggregation
Chemical_Nomenclature : N-(2-((6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl)-2-(2-hydroxyphenyl)-1H-benzoimidazole-6-carboxamide
Canonical SMILES : C1CCC2=NC3=C(C=CC(=C3)Cl)C(=C2C1)NCCNC(=O)C4=CC5=C(C=C4)N=C(N5)C6=CC=CC=C6O
InChI : InChI=1S\/C29H26ClN5O2\/c30-18-10-11-20-24(16-18)33-22-7-3-1-5-19(22)27(20)31-13-14-32-29(37)17-9-12-23-25(15-17)35-28(34-23)21-6-2-4-8-26(21)36\/h2,4,6,8-12,15-16,36H,1,3,5,7,13-14H2,(H,31,33)(H,32,37)(H,34,35)
InChIKey : OJAMDTRMLFVNDW-UHFFFAOYSA-N
Other name(s) : Compound 11d || CHEMBL4218085 || BDBM50458110
MW : 512
Formula : C29H26ClN5O2
CAS_number :
PubChem : 145969382
UniChem : OJAMDTRMLFVNDW-UHFFFAOYSA-N
Target
Families : TAC-BIM-11d ligand of proteins in family
ACHE
References (2)
| Title : Exploring the chelating capacity of 2-hydroxyphenyl-benzimidazole based hybrids with multi-target ability as anti-Alzheimer's agents - Chaves_2018_New.J.Chem_42_16503 |
| Author(s) : Chaves S , Hiremathad A , Tomas D , Keri RS , Piemontese L , Santos MA |
| Ref : New Journal of Chemistry , 42 :16503 , 2018 |
| Abstract : |
| PubMedSearch : Chaves_2018_New.J.Chem_42_16503 |
| PubMedID: |
| Title : Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease - Hiremathad_2018_Eur.J.Med.Chem_148_255 |
| Author(s) : Hiremathad A , Keri RS , Esteves AR , Cardoso SM , Chaves S , Santos MA |
| Ref : Eur Journal of Medicinal Chemistry , 148 :255 , 2018 |
| Abstract : |
| PubMedSearch : Hiremathad_2018_Eur.J.Med.Chem_148_255 |
| PubMedID: 29466775 |