Tacrine-cinnamic-hybrid-cpd10g
AChE electrophorus electricus (eeAChE) IC50 37.02 nM; eqBuChE IC50 101.40 nM; inhibited amyloid beta-protein self-aggregation by 65.49% at 25 microM
General
Type : Derivative of Tacrine, Multitarget, Feruloyl, Acrylate, Hydroxycinnamic-ester, Alkyl linked bis-ligand
Chemical_Nomenclature : (E)-3(4-((3,4-dimethylbenzyl)oxy)-3-methoxyphenyl)-N-(2-((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl)acrylamide
Canonical SMILES : C1=CC=C2C(=C1)C(=C3C(=N2)CCCC3)NCCNC(C=CC4=CC(=C(C=C4)OCC5=CC(=C(C=C5)C)C)OC)=O
InChI : InChI=1S\/C34H37N3O3\/c1-23-12-13-26(20-24(23)2)22-40-31-16-14-25(21-32(31)39-3)15-17-33(38)35-18-19-36-34-27-8-4-6-10-29(27)37-30-11-7-5-9-28(30)34\/h4,6,8,10,12-17,20-21H,5,7,9,11,18-19,22H2,1-3H3,(H,35,38)(H,36,37)
InChIKey : METDMNIIYDCSMU-UHFFFAOYSA-N
Other name(s) : Compound 10g
Target
Families : Tacrine-cinnamic-hybrid-cpd10g ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer's disease - Zhu_2018_J.Enzyme.Inhib.Med.Chem_33_496 |
| Author(s) : Zhu J , Yang H , Chen Y , Lin H , Li Q , Mo J , Bian Y , Pei Y , Sun H |
| Ref : J Enzyme Inhib Med Chem , 33 :496 , 2018 |
| Abstract : |
| PubMedSearch : Zhu_2018_J.Enzyme.Inhib.Med.Chem_33_496 |
| PubMedID: 29405075 |