Tacrine-dipicolylamine-13a
General
Type : Derivative of Tacrine, Alkyl linked bis-ligand, Multitarget, anti-Abeta-aggregation
Chemical_Nomenclature : 4-(bis(pyridin-2-ylmethyl)amino)-N-(3-((1,2,3,4-tetrahydroacridin-9-yl) amino)propyl)butanamide
Canonical SMILES : C1=CC=C2C(=C1)C=C3C(=N2)CCCC3NCCCNC(CCCN(CC4=CC=CC=N4)CC5=NC=CC=C5)=O
InChI : InChI=1S\/C32H38N6O\/c39-32(16-8-21-38(23-26-11-3-5-17-33-26)24-27-12-4-6-18-34-27)36-20-9-19-35-30-14-7-15-31-28(30)22-25-10-1-2-13-29(25)37-31\/h1-6,10-13,17-18,22,30,35H,7-9,14-16,19-21,23-24H2,(H,36,39)
InChIKey : IKFNPBKCHOBIEE-UHFFFAOYSA-N
Other name(s) :
Target
Families : Tacrine-dipicolylamine-13a ligand of proteins in family
ACHE
References (1)
| Title : Design and synthesis of novel tacrine-dipicolylamine dimers that are multiple-target-directed ligands with potential to treat Alzheimer's disease - Zhang_2021_Bioorg.Chem_116_105387 |
| Author(s) : Zhang P , Wang Z , Mou C , Zou J , Xie Y , Liu Z , Benjamin Naman C , Mao Y , Wei J , Huang X , Dong J , Yang M , Wang N , Jin H , Liu F , Lin D , Liu H , Zhou F , He S , Zhang B , Cui W |
| Ref : Bioorg Chem , 116 :105387 , 2021 |
| Abstract : |
| PubMedSearch : Zhang_2021_Bioorg.Chem_116_105387 |
| PubMedID: 34628225 |