Tacrine-dipicolylamine-13a
General
Type : Derivative of Tacrine, Acridine, Alkyl linked bis-ligand, Multitarget, anti-Abeta-aggregation
Chemical_Nomenclature : 4-[bis(pyridin-2-ylmethyl)amino]-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
Canonical SMILES : C1CCC2=NC3=CC=CC=C3C(=C2C1)NCCCNC(=O)CCCN(CC4=CC=CC=N4)CC5=CC=CC=N5
InChI : InChI=1S\/C32H38N6O\/c39-31(17-9-22-38(23-25-11-5-7-18-33-25)24-26-12-6-8-19-34-26)35-20-10-21-36-32-27-13-1-3-15-29(27)37-30-16-4-2-14-28(30)32\/h1,3,5-8,11-13,15,18-19H,2,4,9-10,14,16-17,20-24H2,(H,35,39)(H,36,37)
InChIKey : QCNTULDFOJXDDB-UHFFFAOYSA-N
Other name(s) : CHEMBL5420147
MW : 522.7
Formula : C32H38N6O
CAS_number :
PubChem : 172460030
UniChem : QCNTULDFOJXDDB-UHFFFAOYSA-N
Target
Families : Tacrine-dipicolylamine-13a ligand of proteins in family
ACHE
References (2)
| Title : Recent advance on pleiotropic cholinesterase inhibitors bearing amyloid modulation efficacy - Zhang_2022_Eur.J.Med.Chem_242_114695 |
| Author(s) : Zhang H , Peng Y , Zhuo L , Wang Y , Zeng G , Wang S , Long L , Li X , Wang Z |
| Ref : Eur Journal of Medicinal Chemistry , 242 :114695 , 2022 |
| Abstract : |
| PubMedSearch : Zhang_2022_Eur.J.Med.Chem_242_114695 |
| PubMedID: 36044812 |
| Title : Design and synthesis of novel tacrine-dipicolylamine dimers that are multiple-target-directed ligands with potential to treat Alzheimer's disease - Zhang_2021_Bioorg.Chem_116_105387 |
| Author(s) : Zhang P , Wang Z , Mou C , Zou J , Xie Y , Liu Z , Benjamin Naman C , Mao Y , Wei J , Huang X , Dong J , Yang M , Wang N , Jin H , Liu F , Lin D , Liu H , Zhou F , He S , Zhang B , Cui W |
| Ref : Bioorg Chem , 116 :105387 , 2021 |
| Abstract : |
| PubMedSearch : Zhang_2021_Bioorg.Chem_116_105387 |
| PubMedID: 34628225 |