Thiophen-amino-chromen-2-one-Cpd6h
IC50 nM AChE 26.03 +/- 3.99; hBChE 90.02 +/- 6.71 GSK-3beta 26.91 +/- 2.19
General
Type : Chromen, Sulfur Compound, Thiophen, GSK-3 kinase inhibitor, anti-tau-aggregation, Multitarget
Chemical_Nomenclature : (E\/Z)-6-{[3-oxo-3-(thiophen-2-yl)prop-1-en-1-yl]amino}2H-chromen-2-one
Canonical SMILES : C3(C(C=CNC1=CC=C2C(=C1)C=CC(O2)=O)=O)SCCC3
InChI : InChI=1S\/C16H15NO3S\/c18-13(15-2-1-9-21-15)7-8-17-12-4-5-14-11(10-12)3-6-16(19)20-14\/h3-8,10,15,17H,1-2,9H2
InChIKey : NKAYOTQRDXPLFD-UHFFFAOYSA-N
Other name(s) : Compound 6h
Target
Families : Thiophen-amino-chromen-2-one-Cpd6h ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Rational design, synthesis and computational studies of multi-targeted anti-Alzheimer's agents integrating coumarin scaffold - Abd El-Mageed_2024_Bioorg.Chem_154_108024 |
| Author(s) : Abd El-Mageed MMA , Fattah Ezzat MA , Moussa SA , Abdel-Aziz HA , Elmasry GF |
| Ref : Bioorg Chem , 154 :108024 , 2024 |
| Abstract : |
| PubMedSearch : Abd El-Mageed_2024_Bioorg.Chem_154_108024 |
| PubMedID: 39642754 |