Tominostat
Derivative of 1G244 ; IC50 DPP8 0.05 +/- 0.005 microM; DPP8 0.54 +/- 0.04 microM; DPP4 >25 microM
General
Type : Indole, Isoindole, Piperazine
Chemical_Nomenclature : (2S)-2-amino-4-[(3S)-4-[bis(4-fluorophenyl)methyl]-3-methylpiperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione
Canonical SMILES : C[C@H]1CN(CCN1C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)C[C@@H](C(=O)N4CC5=CC=CC=C5C4)N
InChI : InChI=1S\/C30H32F2N4O2\/c1-20-17-34(28(37)16-27(33)30(38)35-18-23-4-2-3-5-24(23)19-35)14-15-36(20)29(21-6-10-25(31)11-7-21)22-8-12-26(32)13-9-22\/h2-13,20,27,29H,14-19,33H2,1H3\/t20-,27-\/m0\/s1
InChIKey : VAHNMPYIDDIFGT-DCFHFQCYSA-N
Other name(s) : CHEMBL1814748 || CHEMBL1851632 || GTPL12943 || BDBM50350172 || compound 12m
MW : 518.6
Formula : C30H32F2N4O2
CAS_number :
PubChem : 53466122
UniChem : VAHNMPYIDDIFGT-DCFHFQCYSA-N
Target
Families : Tominostat ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-DPP8
References (2)
| Title : DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies - Kikuchi_2023_Cells_12_ |
| Author(s) : Kikuchi S , Wada A , Kamihara Y , Okazaki K , Jawaid P , Rehman MU , Kobayashi E , Susukida T , Minemura T , Nabe Y , Iwao N , Ozawa T , Hatano R , Yamada M , Kishi H , Matsuya Y , Mizuguchi M , Hayakawa Y , Dang NH , Sakamoto Y , Morimoto C , Sato T |
| Ref : Cells , 12 : , 2023 |
| Abstract : |
| PubMedSearch : Kikuchi_2023_Cells_12_ |
| PubMedID: 37048172 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? - Van Goethem_2011_J.Med.Chem_54_5737 |
| Author(s) : Van Goethem S , Matheeussen V , Joossens J , Lambeir AM , Chen X , De Meester I , Haemers A , Augustyns K , Van der Veken P |
| Ref : Journal of Medicinal Chemistry , 54 :5737 , 2011 |
| Abstract : |
| PubMedSearch : Van Goethem_2011_J.Med.Chem_54_5737 |
| PubMedID: 21711053 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |