VAV-8
IC50 eleelAChE 0.171 +/- 0.07 MAO-B 0.078 +/- 0.009
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Morpholine, Quinazoline, Piperidine, Alkyne
Chemical_Nomenclature : 4-[2-(3-methoxy-4-prop-2-ynoxyphenyl)quinazolin-4-yl]morpholine
Canonical SMILES : COC1=C(C=CC(=C1)C2=NC3=CC=CC=C3C(=N2)N4CCOCC4)OCC#C
InChI : InChI=1S\/C22H21N3O3\/c1-3-12-28-19-9-8-16(15-20(19)26-2)21-23-18-7-5-4-6-17(18)22(24-21)25-10-13-27-14-11-25\/h1,4-9,15H,10-14H2,2H
InChIKey : XYBWXZIYQJCEEA-UHFFFAOYSA-N
Other name(s) : AChE\/MAO-B-IN-7 || orb2945248 || HY-172101
MW : 375.4
Formula : C22H21N3O3
CAS_number :
PubChem : 172677119
UniChem : XYBWXZIYQJCEEA-UHFFFAOYSA-N
Target
Families : VAV-8 ligand of proteins in family
ACHE
References (3)
| Title : In vitro and in vivo Investigations of 4-Substituted 2-Phenylquinazoline derivatives as multipotent ligands for the treatment of Alzheimer's disease - Kumar_2025_Bioorg.Chem_155_108126 |
| Author(s) : Kumar V , Jangid K , Kumar N , Mishra J , Arora T , Dwivedi AR , Kumar P , Bhatti JS , Parkash J |
| Ref : Bioorg Chem , 155 :108126 , 2025 |
| Abstract : |
| PubMedSearch : Kumar_2025_Bioorg.Chem_155_108126 |
| PubMedID: 39798452 |
| Title : In vitro and in vivo Investigations of 4-Substituted 2-Phenylquinazoline derivatives as multipotent ligands for the treatment of Alzheimer's disease - Kumar_2025_Bioorg.Chem_155_108126 |
| Author(s) : Kumar V , Jangid K , Kumar N , Mishra J , Arora T , Dwivedi AR , Kumar P , Bhatti JS , Parkash J |
| Ref : Bioorg Chem , 155 :108126 , 2025 |
| Abstract : |
| PubMedSearch : Kumar_2025_Bioorg.Chem_155_108126 |
| PubMedID: 39798452 |
| Title : In vitro and in vivo Investigations of 4-Substituted 2-Phenylquinazoline derivatives as multipotent ligands for the treatment of Alzheimer's disease - Kumar_2025_Bioorg.Chem_155_108126 |
| Author(s) : Kumar V , Jangid K , Kumar N , Mishra J , Arora T , Dwivedi AR , Kumar P , Bhatti JS , Parkash J |
| Ref : Bioorg Chem , 155 :108126 , 2025 |
| Abstract : |
| PubMedSearch : Kumar_2025_Bioorg.Chem_155_108126 |
| PubMedID: 39798452 |