Z43
Z43 h AChE IC50 = 1.7 +/- 1.4 nM and sEH IC50 = 0.7 +/- 0.3 nM
General
Type : Derivative of Tacrine, Acridine, Cyanide, Trifluoro, Triazol, Multitarget
Chemical_Nomenclature : 3-((1-(2-((6-Chloro-1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)-N-(4-cyano-2-(trifluoromethyl)benzyl)benzamide
Canonical SMILES : C16=C(N=C5C(=C1NCC[N]2N=NC(=C2)COC3=CC(=CC=C3)C(NCC4=C(C=C(C=C4)C#N)C(F)(F)F)=O)CCCC5)C=C(C=C6)Cl
InChI : InChI=1S\/C34H29ClF3N7O2\/c35-24-10-11-28-31(16-24)42-30-7-2-1-6-27(30)32(28)40-12-13-45-19-25(43-44-45)20-47-26-5-3-4-22(15-26)33(46)41-18-23-9-8-21(17-39)14-29(23)34(36,37)38\/h3-5,8-11,14-16,19H,1-2,6-7,12-13,18,20H2,(H,40,42)(H,41,46)
InChIKey : PGAAWVSNOBOJSG-UHFFFAOYSA-N
Other name(s) :
Target
Families : Z43 ligand of proteins in family
ACHE
Epoxide_hydrolase
Protein :
human-ACHE
human-EPHX2
References (1)
| Title : Design, synthesis, and evaluation of dual-target inhibitors of acetylcholinesterase (AChE) and soluble epoxide hydrolase (sEH) for the treatment of Alzheimer's disease - Zhao_2026_Eur.J.Med.Chem_312_118844 |
| Author(s) : Zhao X , Bao Y , Wan X , Miao R , Li C , Wang J , Zhang H , Xiang Y , Pang Y , Miao Z , Tong M , Shi X , Wang H , Gong P , Zhao Y , Hou Y |
| Ref : Eur Journal of Medicinal Chemistry , 312 :118844 , 2026 |
| Abstract : |
| PubMedSearch : Zhao_2026_Eur.J.Med.Chem_312_118844 |
| PubMedID: 42013744 |