ZINC22029744
IC50 hAChE 0.907+/-0.011 microM; hBChE 1.579+/-0.037microM; hBACE-1 0.753+/-0.018 microM
General
Type : Multitarget, Sulfur Compound, Derivative of Donepezil, BACE1-inhibitor, Piperazine, Oxadiazol
Chemical_Nomenclature : 3-[(4-benzylpiperazin-1-yl)methyl]-5-phenyl-1,3,4-oxadiazole-2-thione
Canonical SMILES : C1CN(CCN1CC2=CC=CC=C2)CN3C(=S)OC(=N3)C4=CC=CC=C4
InChI : InChI=1S\/C20H22N4OS\/c26-20-24(21-19(25-20)18-9-5-2-6-10-18)16-23-13-11-22(12-14-23)15-17-7-3-1-4-8-17\/h1-10H,11-16H2
InChIKey : ONVSVBRUYFMQPZ-UHFFFAOYSA-N
Other name(s) : SD6 || SD-6 || 3-((4-Benzylpiperazin-1-yl)methyl)-5-phenyl-1,3,4-oxadiazole-2(3H)-thione || AKOS034336734 || Z44097414
MW : 366.5
Formula : C20H22N4OS
CAS_number :
PubChem : 2096125
UniChem : ONVSVBRUYFMQPZ-UHFFFAOYSA-N
References (1)
| Title : Development and Evaluation of Some Molecular Hybrids of N-(1-Benzylpiperidin-4-yl)-2-((5-phenyl-1,3,4-oxadiazol-2-yl)thio) as Multifunctional Agents to Combat Alzheimer's Disease - Waiker_2023_ACS.Omega_8_9394 |
| Author(s) : Waiker DK , Verma A , Saraf P , T AG , Krishnamurthy S , Chaurasia RN , Shrivastava SK |
| Ref : ACS Omega , 8 :9394 , 2023 |
| Abstract : |
| PubMedSearch : Waiker_2023_ACS.Omega_8_9394 |
| PubMedID: 36936338 |