hAChE-IN-6
hAChE-IN-6 (compound 51) is a brain penetrant AChE inhibitor with an IC50 of 0.16 microM. hAChE-IN-6 also inhibits hBuChE and GSK3 with IC50 values of 0.69 microM and 0.26 microM, respectively. hAChE-IN-6 inhibits tau protein and A1-42 self-aggregation
General
Type : Pyridine, Pyrazole, GSK-3 kinase inhibitor, Multitarget
Chemical_Nomenclature : 6-(4-bromophenyl)-4-(3,4-dimethoxyphenyl)-2H-pyrazolo[3,4-b]pyridin-3-amine
Canonical SMILES : COC1=C(C=C(C=C1)C2=CC(=NC3=NNC(=C23)N)C4=CC=C(C=C4)Br)OC
InChI : InChI=1S\/C20H17BrN4O2\/c1-26-16-8-5-12(9-17(16)27-2)14-10-15(11-3-6-13(21)7-4-11)23-20-18(14)19(22)24-25-20\/h3-10H,1-2H3,(H3,22,23,24,25)
InChIKey : CFUZORHXMOWNMN-UHFFFAOYSA-N
Other name(s) : HY-155366 || CS-0901310
MW : 425.34
Formula : C20H17BrN4O2
CAS_number :
PubChem : 169450253
UniChem : CFUZORHXMOWNMN-UHFFFAOYSA-N
Target
Families : hAChE-IN-6 ligand of proteins in family
BCHE
ACHE
Protein :
human-BCHE
human-ACHE
References (1)
| Title : Multi-targeted anti-Alzheimer's agents: Synthesis, biological evaluation, and molecular modeling study of some pyrazolopyridine hybrids - Waly_2023_Eur.J.Med.Chem_262_115880 |
| Author(s) : Waly OM , El-Sayed SM , Ghaly MA , El-Subbagh HI |
| Ref : Eur Journal of Medicinal Chemistry , 262 :115880 , 2023 |
| Abstract : |
| PubMedSearch : Waly_2023_Eur.J.Med.Chem_262_115880 |
| PubMedID: 37871406 |