t-TUCB-PROTAC-Cpd8
General
Type : Urea derivative, Trifluoro, PROTAC, Multitarget, Piperazine
Chemical_Nomenclature :
Canonical SMILES : C1(=CC=C(C=C1)C(=O)NCCCCCCCCC(N2CCC(CC2)CN3CCN(CC3)C4=CC=C5C(=C4)C(N(C5=O)C6C(NC(CC6)=O)=O)=O)=O)O[C@@H]7CC[C@H](CC7)NC(=O)NC8=CC=C(C=C8)OC(F)(F)F
InChI : InChI=1S\/C53H65F3N8O9\/c54-53(55,56)73-42-19-12-38(13-20-42)59-52(71)58-37-10-17-41(18-11-37)72-40-15-8-36(9-16-40)48(67)57-26-6-4-2-1-3-5-7-47(66)63-27-24-35(25-28-63)34-61-29-31-62(32-30-61)39-14-21-43-44(33-39)51(70)64(50(43)69)45-22-23-46(65)60-49(45)68\/h8-9,12-16,19-21,33,35,37,41,45H,1-7,10-11,17-18,22-32,34H2,(H,57,67)(H2,58,59,71)(H,60,65,68)\/t37-,41-,45?
InChIKey : MOQMDQNVGXKCGH-PRCONFNSSA-N
Other name(s) :
Target
Families : t-TUCB-PROTAC-Cpd8 ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (2)
| Title : In Vivo-Active Soluble Epoxide Hydrolase-Targeting PROTACs with Improved Potency and Stability - Nakane_2024_ACS.Med.Chem.Lett_15_1891 |
| Author(s) : Nakane K , Morisseau C , Dowker-Key PD , Benitez G , Aguilan JT , Nagai E , Sidoli S , Hammock BD , Bettaieb A , Shinoda K , Kitamura S |
| Ref : ACS Med Chem Lett , 15 :1891 , 2024 |
| Abstract : |
| PubMedSearch : Nakane_2024_ACS.Med.Chem.Lett_15_1891 |
| PubMedID: 39563815 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : In vivo -Active Soluble Epoxide Hydrolase-targeting PROTACs with Improved Potency and Stability - Nakane_2024_bioRxiv__ |
| Author(s) : Nakane K , Morisseau C , Dowker-Key PD , Benitez G , Aguilan JT , Nagai E , Sidoli S , Hammock BD , Bettaieb A , Shinoda K , Kitamura S |
| Ref : Biorxiv , : , 2024 |
| Abstract : |
| PubMedSearch : Nakane_2024_bioRxiv__ |
| PubMedID: 39211216 |