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Inhibitor Report for: (4-fluoroanilino)thiourea

Not inhibitor of Notum. Compound 59 Fragment 274


General
Type Fragment inhibitor of Notum, Urea derivative, Sulfur Compound
Chemical_Nomenclature (4-fluoroanilino)thiourea
Canonical SMILES C1=CC(=CC=C1NNC(=S)N)F
InChI InChI=1S/C7H8FN3S/c8-5-1-3-6(4-2-5)10-11-7(9)12/h1-4,10H,(H3,9,11,12)
InChIKey KQNHAXWTVPXGMP-UHFFFAOYSA-N
Other name(s) 2-(4-Fluorophenyl)-1-hydrazinecarbothioamide ; [(4-fluorophenyl)amino]thiourea ; 2-(4-Fluorophenyl)hydrazinecarbothioamide ; SCHEMBL458638 ; ZINC69512 ; U5Z ; Fragment-274 ; Fragment 274 ; Compound 59
________________________________________________________________________________________________
MW|185.22
Formula|C7H8FN3S
CAS_number|280133-47-3
PubChem|2782955
UniChem|KQNHAXWTVPXGMP-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | (4-fluoroanilino)thiourea ligand of proteins in family: Pectinacetylesterase-Notum
Stucture | 1 structure: 7BO1: Human Notum complexed with Fragment_274 [(4-fluorophenyl)amino]thiourea ((4-fluoroanilino)thiourea)
Protein | human-NOTUM

References:
Search PubMed for references concerning: (4-fluoroanilino)thiourea
    Title: Structural Analysis and Development of Notum Fragment Screening Hits
    Zhao Y, Mahy W, Willis NJ, Woodward HL, Steadman D, Bayle ED, Atkinson BN, Sipthorp J, Vecchia L and Jones EY <11 more author(s)>
    Ref: ACS Chem Neurosci, 13:2060, 2022 : PubMed