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Inhibitor Report for: CHEMBL2147710

General
Type Trifluoro, Pyrrolidine, Thiazolidine, Sulfur Compound, Pyrazole
Chemical_Nomenclature [(2S,4S)-4-[4-[2-phenyl-5-(trifluoromethyl)pyrazol-3-yl]piperidin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone
Canonical SMILES C1CN(CCC1C2=CC(=NN2C3=CC=CC=C3)C(F)(F)F)C4CC(NC4)C(=O)N5CCSC5
InChI InChI=1S/C23H28F3N5OS/c24-23(25,26)21-13-20(31(28-21)17-4-2-1-3-5-17)16-6-8-29(9-7-16)18-12-19(27-14-18)22(32)30-10-11-33-15-30/h1-5,13,16,18-19,27H,6-12,14-15H2/t18-,19-/m0/s1
InChIKey CYNIHEXFNGMKLP-OALUTQOASA-N
Other name(s) CHEMBL2147710 ; BDBM50391574 ; [(2s,4s)-4-{4-[1-Phenyl-3-(Trifluoromethyl)-1h-Pyrazol-5-Yl]piperidin-1-Yl}pyrrolidin-2-Yl](1,3-Thiazolidin-3-Yl)methanone ; W94
________________________________________________________________________________________________
MW|479.56
Formula|C23H28F3N5OS
CAS_number|
PubChem|66545741
UniChem|CYNIHEXFNGMKLP-OALUTQOASA-N
IUPHAR|
Wikipedia|

Target
Families | CHEMBL2147710 ligand of proteins in family: DPP4N_Peptidase_S9
Stucture | 1 structure: 3VJL: Crystal structure of human dipeptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor 2
Protein | human-DPP4

References:
Search PubMed for references concerning: CHEMBL2147710

1 more
    Title: Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-y lcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
    Yoshida T, Akahoshi F, Sakashita H, Kitajima H, Nakamura M, Sonda S, Takeuchi M, Tanaka Y, Ueda N and Hayashi Y <20 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry, 20:5705, 2012 : PubMed

            

    Title: Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group
    Yoshida T, Akahoshi F, Sakashita H, Sonda S, Takeuchi M, Tanaka Y, Nabeno M, Kishida H, Miyaguchi I, Hayashi Y
    Ref: Bioorganic & Medicinal Chemistry, 20:5033, 2012 : PubMed

            

    Title: [(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors
    Yoshida T, Sakashita H, Akahoshi F, Hayashi Y
    Ref: Bioorganic & Medicinal Chemistry Lett, 17:2618, 2007 : PubMed