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Inhibitor Report for: Octyl-Benzisothiazolinone

General
Type Thiazolinone, Sulfur Compound
Chemical_Nomenclature 2-octyl-1,2-benzothiazol-3-one
Canonical SMILES CCCCCCCCN1C(=O)C2=CC=CC=C2S1
InChI InChI=1S/C15H21NOS/c1-2-3-4-5-6-9-12-16-15(17)13-10-7-8-11-14(13)18-16/h7-8,10-11H,2-6,9,12H2,1H3
InChIKey WVGPLHUTLSZSGX-UHFFFAOYSA-N
Other name(s) BTZ-7 ; CHEMBL1922513 ; 1,2-Benzisothiazol-3(2H)-one, 2-octyl- ; ACMC-20n0gg ; SCHEMBL1538479
________________________________________________________________________________________________
MW|263.4
Formula|C15H21NOS
CAS_number|141426-19-9
PubChem|18927006
UniChem|WVGPLHUTLSZSGX-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Octyl-Benzisothiazolinone ligand of proteins in family: Monoglyceridelipase_lysophospholip
Protein | human-MGLL

References:
Search PubMed for references concerning: Octyl-Benzisothiazolinone
    Title: Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteines
    Castelli R, Scalvini L, Vacondio F, Lodola A, Anselmi M, Vezzosi S, Carmi C, Bassi M, Ferlenghi F and Piomelli D <11 more author(s)>
    Ref: Journal of Medicinal Chemistry, 63:1261, 2020 : PubMed

            

    Title: Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone
    Matuszak N, Es Saadi B, Labar G, Marchand-Brynaert J, Lambert DM
    Ref: Bioorganic & Medicinal Chemistry Lett, 21:7321, 2011 : PubMed