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WWL229

General

Type : pNP,Carbamate,Piperidine

Chemical_Nomenclature : (4-nitrophenyl) 2-(3-methoxypropyl)piperidine-1-carboxylate

Canonical SMILES : COCCCC1CCCCN1C(=O)OC2=CC=C(C=C2)[N+](=O)[O-]

InChI : InChI=1S\/C16H22N2O5\/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21\/h7-10,13H,2-6,11-12H2,1H3

InChIKey : XVBRVSAGMWRVCK-UHFFFAOYSA-N

Other name(s) : Wwl229,4-Nitrophenyl 2-(3-methoxypropyl)piperidine-1-carboxylate,AOB2408,SYN5249,MolPort-039-138-796

---

MW : 322.36

Formula : C16H22N2O5

CAS_number : 1338575-28-2

PubChem : 72183487

UniChem : XVBRVSAGMWRVCK-UHFFFAOYSA-N

Target

Families : WWL229 ligand of proteins in family
Carb_B_Chordata

Protein :
human-CES3 mouse-Ces1d

References (2)

1. A Unique Role of Carboxylesterase 3 (Ces3) in beta-Adrenergic Signaling-Stimulated Thermogenesis

Title : A Unique Role of Carboxylesterase 3 (Ces3) in beta-Adrenergic Signaling-Stimulated Thermogenesis - Yang_2019_Diabetes_68_1178

Author(s) : Yang L , Li X , Tang H , Gao Z , Zhang K , Sun K

Ref : Diabetes , 68 :1178 , 2019

Abstract : Yang_2019_Diabetes_68_1178

ESTHER : Yang_2019_Diabetes_68_1178

PubMedSearch : Yang_2019_Diabetes_68_1178

PubMedID: 30862682

Gene_locus related to this paper: human-CES3 , mouse-Ces1d

2. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

Title : Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes - Dominguez_2014_Nat.Chem.Biol_10_113

Author(s) : Dominguez E , Galmozzi A , Chang JW , Hsu KL , Pawlak J , Li W , Godio C , Thomas J , Partida D , Niessen S , O'Brien PE , Russell AP , Watt MJ , Nomura DK , Cravatt BF , Saez E

Ref : Nat Chemical Biology , 10 :113 , 2014

Abstract : Dominguez_2014_Nat.Chem.Biol_10_113

ESTHER : Dominguez_2014_Nat.Chem.Biol_10_113

PubMedSearch : Dominguez_2014_Nat.Chem.Biol_10_113

PubMedID: 24362705

Gene_locus related to this paper: human-CES3 , mouse-Ces1d

Array
(
    [id] => 4227
    [inhibitor] => WWL229
    [type] => Array
        (
            [0] => pNP
            [1] => Carbamate
            [2] => Piperidine
        )

    [other_name] => Array
        (
            [0] => Wwl229
            [1] => 4-Nitrophenyl 2-(3-methoxypropyl)piperidine-1-carboxylate
            [2] => AOB2408
            [3] => SYN5249
            [4] => MolPort-039-138-796
        )

    [chemical_nomenclature] => (4-nitrophenyl) 2-(3-methoxypropyl)piperidine-1-carboxylate
    [formula] => C16H22N2O5
    [cas_number] => 1338575-28-2
    [mw] => 322.36
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Dominguez_2014_Nat.Chem.Biol_10_113 || Yang_2019_Diabetes_68_1178
    [comment] => 
    [gene_locus] => human-CES3 || mouse-Ces1d
    [kin_inhibitor] => 
    [cid] => 72183487
    [family] => Carb_B_Chordata
    [inchikey] => XVBRVSAGMWRVCK-UHFFFAOYSA-N
    [canonicalsmiles] => COCCCC1CCCCN1C(=O)OC2=CC=C(C=C2)[N+](=O)[O-]
    [inchi] => InChI=1S\/C16H22N2O5\/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21\/h7-10,13H,2-6,11-12H2,1H3
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)