human-CES3

Homo sapiens (Human) Carboxylesterase 3 (Brain) Liver carboxylesterase 31 homolog

Comment

Previously human-lcxes Homo sapiens hypothetical protein FLJ21736 (FLJ21736), mRNA. Very close to the Chr4 human-cxes2 In reverse orientation separated by a gene of carbonic anhydrase

Relationship

Family : Carb_B_Chordata

Block : C

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

Sequence

Peptide

MERAVRVESG VLVGVVCLLL ACPATATGPE VAQPEVDTTL GRVRGRQVGV KGTDRLVNVF LGIPFAQPPL GPDRFSAPHP AQPWEGVRDA STAPPMCLQD VESMNSSRFV LNGKQQIFSV SEDCLVLNVY SPAEVPAGSG RPVMVWVHGG ALITGAATSY DGSALAAYGD VVVVTVQYRL GVLGFFSTGD EHAPGNQGFL DVVAALRWVQ ENIAPFGGDL NCVTVFGGSA GGSIISGLVL SPVAAGLFHR AITQSGVITT PGIIDSHPWP LAQKIANTLA CSSSSPAEMV QCLQQKEGEE LVLSKKLKNT IYPLTVDGTV FPKSPKELLK EKPFHSVPFL MGVNNHEFSW LIPRGWGLLD TMEQMSREDM LAISTPVLTS LDVPPEMMPT VIDEYLGSNS DAQAKCQAFQ EFMGDVFINV PTVSFSRYLR DSGSPVFFYE FQHRPSSFAK IKPAWVKADH GAEGAFVFGG PFLMDESSRL AFPEATEEEK QLSLTMMAQW THFARTGDPN SKALPPWPQF NQAEQYLEIN PVPRAGQKFR EAWMQFWSET LPSKIQQWHQ KQKNRKAQED L

References (14)

Title : A potential novel biomarker: comprehensive analysis of prognostic value and immune implication of CES3 in colonic adenocarcinoma - He_2023_J.Cancer.Res.Clin.Oncol__
Author(s) : He L , Zhao C , Xu J , Li W , Lu Y , Gong Y , Gu D , Wang X , Guo F
Ref : J Cancer Research Clin Oncol , : , 2023
PubMedID: 37480527
Gene_locus related to this paper: human-CES3

Title : A Unique Role of Carboxylesterase 3 (Ces3) in beta-Adrenergic Signaling-Stimulated Thermogenesis - Yang_2019_Diabetes_68_1178
Author(s) : Yang L , Li X , Tang H , Gao Z , Zhang K , Sun K
Ref : Diabetes , 68 :1178 , 2019
PubMedID: 30862682
Gene_locus related to this paper: human-CES3 , mouse-Ces1d

Title : Novel regulatory roles of carboxylesterase 3 in lipid metabolism and browning in 3T3-L1 white adipocytes - Mukherjee_2019_Appl.Physiol.Nutr.Metab_44_1089
Author(s) : Mukherjee S , Choi M , Yun JW
Ref : Appl Physiol Nutr Metab , 44 :1089 , 2019
PubMedID: 30807212
Gene_locus related to this paper: human-CES3 , mouse-Ces3a

Title : Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes - Dominguez_2014_Nat.Chem.Biol_10_113
Author(s) : Dominguez E , Galmozzi A , Chang JW , Hsu KL , Pawlak J , Li W , Godio C , Thomas J , Partida D , Niessen S , O'Brien PE , Russell AP , Watt MJ , Nomura DK , Cravatt BF , Saez E
Ref : Nat Chemical Biology , 10 :113 , 2014
PubMedID: 24362705
Gene_locus related to this paper: human-CES3 , mouse-Ces1d

Title : Identification of a novel intracellular cholesteryl ester hydrolase (carboxylesterase 3) in human macrophages: compensatory increase in its expression after carboxylesterase 1 silencing - Zhao_2012_Am.J.Physiol.Cell.Physiol_303_C427
Author(s) : Zhao B , Bie J , Wang J , Marqueen SA , Ghosh S
Ref : American Journal of Physiology Cell Physiol , 303 :C427 , 2012
PubMedID: 22700792
Gene_locus related to this paper: human-CES3

Title : Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins - Holmes_2010_Mamm.Genome_21_427
Author(s) : Holmes RS , Wright MW , Laulederkind SJ , Cox LA , Hosokawa M , Imai T , Ishibashi S , Lehner R , Miyazaki M , Perkins EJ , Potter PM , Redinbo MR , Robert J , Satoh T , Yamashita T , Yan B , Yokoi T , Zechner R , Maltais LJ
Ref : Mamm Genome , 21 :427 , 2010
PubMedID: 20931200
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A

Title : Mammalian carboxylesterase 3: comparative genomics and proteomics - Holmes_2010_Genetica_138_695
Author(s) : Holmes RS , Cox LA , Vandeberg JL
Ref : Genetica , 138 :695 , 2010
PubMedID: 20422440
Gene_locus related to this paper: human-CES3

Title : Human carboxylesterases: an update on CES1, CES2 and CES3 - Sanghani_2009_Protein.Pept.Lett_16_1207
Author(s) : Sanghani SP , Sanghani PC , Schiel MA , Bosron WF
Ref : Protein Pept Lett , 16 :1207 , 2009
PubMedID: 19508181
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3

Title : Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes - Hosokawa_2007_Drug.Metab.Rev_39_1
Author(s) : Hosokawa M , Furihata T , Yaginuma Y , Yamamoto N , Koyano N , Fujii A , Nagahara Y , Satoh T , Chiba K
Ref : Drug Metabolism Reviews , 39 :1 , 2007
PubMedID: 17364878
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A

Title : Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide - Quinney_2005_J.Pharmacol.Exp.Ther_313_1011
Author(s) : Quinney SK , Sanghani SP , Davis WI , Hurley TD , Sun Z , Murry DJ , Bosron WF
Ref : Journal of Pharmacology & Experimental Therapeutics , 313 :1011 , 2005
PubMedID: 15687373
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3

Title : Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3 - Sanghani_2004_Drug.Metab.Dispos_32_505
Author(s) : Sanghani SP , Quinney SK , Fredenburg TB , Davis WI , Murry DJ , Bosron WF
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 32 :505 , 2004
PubMedID: 15100172
Gene_locus related to this paper: human-CES2 , human-CES3

Title : The sequence and analysis of duplication-rich human chromosome 16 - Martin_2004_Nature_432_988
Author(s) : Martin J , Han C , Gordon LA , Terry A , Prabhakar S , She X , Xie G , Hellsten U , Chan YM , Altherr M , Couronne O , Aerts A , Bajorek E , Black S , Blumer H , Branscomb E , Brown NC , Bruno WJ , Buckingham JM , Callen DF , Campbell CS , Campbell ML , Campbell EW , Caoile C , Challacombe JF , Chasteen LA , Chertkov O , Chi HC , Christensen M , Clark LM , Cohn JD , Denys M , Detter JC , Dickson M , Dimitrijevic-Bussod M , Escobar J , Fawcett JJ , Flowers D , Fotopulos D , Glavina T , Gomez M , Gonzales E , Goodstein D , Goodwin LA , Grady DL , Grigoriev I , Groza M , Hammon N , Hawkins T , Haydu L , Hildebrand CE , Huang W , Israni S , Jett J , Jewett PB , Kadner K , Kimball H , Kobayashi A , Krawczyk MC , Leyba T , Longmire JL , Lopez F , Lou Y , Lowry S , Ludeman T , Manohar CF , Mark GA , McMurray KL , Meincke LJ , Morgan J , Moyzis RK , Mundt MO , Munk AC , Nandkeshwar RD , Pitluck S , Pollard M , Predki P , Parson-Quintana B , Ramirez L , Rash S , Retterer J , Ricke DO , Robinson DL , Rodriguez A , Salamov A , Saunders EH , Scott D , Shough T , Stallings RL , Stalvey M , Sutherland RD , Tapia R , Tesmer JG , Thayer N , Thompson LS , Tice H , Torney DC , Tran-Gyamfi M , Tsai M , Ulanovsky LE , Ustaszewska A , Vo N , White PS , Williams AL , Wills PL , Wu JR , Wu K , Yang J , DeJong P , Bruce D , Doggett NA , Deaven L , Schmutz J , Grimwood J , Richardson P , Rokhsar DS , Eichler EE , Gilna P , Lucas SM , Myers RM , Rubin EM , Pennacchio LA
Ref : Nature , 432 :988 , 2004
PubMedID: 15616553
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A

Title : The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment - Clark_2003_Genome.Res_13_2265
Author(s) : Clark HF , Gurney AL , Abaya E , Baker K , Baldwin D , Brush J , Chen J , Chow B , Chui C , Crowley C , Currell B , Deuel B , Dowd P , Eaton D , Foster J , Grimaldi C , Gu Q , Hass PE , Heldens S , Huang A , Kim HS , Klimowski L , Jin Y , Johnson S , Lee J , Lewis L , Liao D , Mark M , Robbie E , Sanchez C , Schoenfeld J , Seshagiri S , Simmons L , Singh J , Smith V , Stinson J , Vagts A , Vandlen R , Watanabe C , Wieand D , Woods K , Xie MH , Yansura D , Yi S , Yu G , Yuan J , Zhang M , Zhang Z , Goddard A , Wood WI , Godowski P , Gray A
Ref : Genome Res , 13 :2265 , 2003
PubMedID: 12975309
Gene_locus related to this paper: human-CES3 , human-CES4A

Title : Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis - Sanghani_2003_Clin.Cancer.Res_9_4983
Author(s) : Sanghani SP , Quinney SK , Fredenburg TB , Sun Z , Davis WI , Murry DJ , Cummings OW , Seitz DE , Bosron WF
Ref : Clin Cancer Research , 9 :4983 , 2003
PubMedID: 14581373
Gene_locus related to this paper: human-CES3