Homo sapiens (Human) Carboxylesterase 3 (Brain) Liver carboxylesterase 31 homolog
Previously human-lcxes Homo sapiens hypothetical protein FLJ21736 (FLJ21736), mRNA. Very close to the Chr4 human-cxes2 In reverse orientation separated by a gene of carbonic anhydrase
Family : Carb_B_Chordata
Block : C
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMERAVRVESG VLVGVVCLLL ACPATATGPE VAQPEVDTTL GRVRGRQVGV KGTDRLVNVF LGIPFAQPPL GPDRFSAPHP AQPWEGVRDA STAPPMCLQD VESMNSSRFV LNGKQQIFSV SEDCLVLNVY SPAEVPAGSG RPVMVWVHGG ALITGAATSY DGSALAAYGD VVVVTVQYRL GVLGFFSTGD EHAPGNQGFL DVVAALRWVQ ENIAPFGGDL NCVTVFGGSA GGSIISGLVL SPVAAGLFHR AITQSGVITT PGIIDSHPWP LAQKIANTLA CSSSSPAEMV QCLQQKEGEE LVLSKKLKNT IYPLTVDGTV FPKSPKELLK EKPFHSVPFL MGVNNHEFSW LIPRGWGLLD TMEQMSREDM LAISTPVLTS LDVPPEMMPT VIDEYLGSNS DAQAKCQAFQ EFMGDVFINV PTVSFSRYLR DSGSPVFFYE FQHRPSSFAK IKPAWVKADH GAEGAFVFGG PFLMDESSRL AFPEATEEEK QLSLTMMAQW THFARTGDPN SKALPPWPQF NQAEQYLEIN PVPRAGQKFR EAWMQFWSET LPSKIQQWHQ KQKNRKAQED L
Title : A potential novel biomarker: comprehensive analysis of prognostic value and immune implication of CES3 in colonic adenocarcinoma - He_2023_J.Cancer.Res.Clin.Oncol__ |
Author(s) : He L , Zhao C , Xu J , Li W , Lu Y , Gong Y , Gu D , Wang X , Guo F |
Ref : J Cancer Research Clin Oncol , : , 2023 |
Abstract : |
PubMedSearch : He_2023_J.Cancer.Res.Clin.Oncol__ |
PubMedID: 37480527 |
Gene_locus related to this paper: human-CES3 |
Title : A Unique Role of Carboxylesterase 3 (Ces3) in beta-Adrenergic Signaling-Stimulated Thermogenesis - Yang_2019_Diabetes_68_1178 |
Author(s) : Yang L , Li X , Tang H , Gao Z , Zhang K , Sun K |
Ref : Diabetes , 68 :1178 , 2019 |
Abstract : |
PubMedSearch : Yang_2019_Diabetes_68_1178 |
PubMedID: 30862682 |
Gene_locus related to this paper: human-CES3 , mouse-Ces1d |
Title : Novel regulatory roles of carboxylesterase 3 in lipid metabolism and browning in 3T3-L1 white adipocytes - Mukherjee_2019_Appl.Physiol.Nutr.Metab_44_1089 |
Author(s) : Mukherjee S , Choi M , Yun JW |
Ref : Appl Physiol Nutr Metab , 44 :1089 , 2019 |
Abstract : |
PubMedSearch : Mukherjee_2019_Appl.Physiol.Nutr.Metab_44_1089 |
PubMedID: 30807212 |
Gene_locus related to this paper: human-CES3 , mouse-Ces3a |
Title : Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes - Dominguez_2014_Nat.Chem.Biol_10_113 |
Author(s) : Dominguez E , Galmozzi A , Chang JW , Hsu KL , Pawlak J , Li W , Godio C , Thomas J , Partida D , Niessen S , O'Brien PE , Russell AP , Watt MJ , Nomura DK , Cravatt BF , Saez E |
Ref : Nat Chemical Biology , 10 :113 , 2014 |
Abstract : |
PubMedSearch : Dominguez_2014_Nat.Chem.Biol_10_113 |
PubMedID: 24362705 |
Gene_locus related to this paper: human-CES3 , mouse-Ces1d |
Title : Identification of a novel intracellular cholesteryl ester hydrolase (carboxylesterase 3) in human macrophages: compensatory increase in its expression after carboxylesterase 1 silencing - Zhao_2012_Am.J.Physiol.Cell.Physiol_303_C427 |
Author(s) : Zhao B , Bie J , Wang J , Marqueen SA , Ghosh S |
Ref : American Journal of Physiology Cell Physiol , 303 :C427 , 2012 |
Abstract : |
PubMedSearch : Zhao_2012_Am.J.Physiol.Cell.Physiol_303_C427 |
PubMedID: 22700792 |
Gene_locus related to this paper: human-CES3 |
Title : Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins - Holmes_2010_Mamm.Genome_21_427 |
Author(s) : Holmes RS , Wright MW , Laulederkind SJ , Cox LA , Hosokawa M , Imai T , Ishibashi S , Lehner R , Miyazaki M , Perkins EJ , Potter PM , Redinbo MR , Robert J , Satoh T , Yamashita T , Yan B , Yokoi T , Zechner R , Maltais LJ |
Ref : Mamm Genome , 21 :427 , 2010 |
Abstract : |
PubMedSearch : Holmes_2010_Mamm.Genome_21_427 |
PubMedID: 20931200 |
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A |
Title : Mammalian carboxylesterase 3: comparative genomics and proteomics - Holmes_2010_Genetica_138_695 |
Author(s) : Holmes RS , Cox LA , Vandeberg JL |
Ref : Genetica , 138 :695 , 2010 |
Abstract : |
PubMedSearch : Holmes_2010_Genetica_138_695 |
PubMedID: 20422440 |
Gene_locus related to this paper: human-CES3 |
Title : Human carboxylesterases: an update on CES1, CES2 and CES3 - Sanghani_2009_Protein.Pept.Lett_16_1207 |
Author(s) : Sanghani SP , Sanghani PC , Schiel MA , Bosron WF |
Ref : Protein Pept Lett , 16 :1207 , 2009 |
Abstract : |
PubMedSearch : Sanghani_2009_Protein.Pept.Lett_16_1207 |
PubMedID: 19508181 |
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 |
Title : Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes - Hosokawa_2007_Drug.Metab.Rev_39_1 |
Author(s) : Hosokawa M , Furihata T , Yaginuma Y , Yamamoto N , Koyano N , Fujii A , Nagahara Y , Satoh T , Chiba K |
Ref : Drug Metabolism Reviews , 39 :1 , 2007 |
Abstract : |
PubMedSearch : Hosokawa_2007_Drug.Metab.Rev_39_1 |
PubMedID: 17364878 |
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A |
Title : Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide - Quinney_2005_J.Pharmacol.Exp.Ther_313_1011 |
Author(s) : Quinney SK , Sanghani SP , Davis WI , Hurley TD , Sun Z , Murry DJ , Bosron WF |
Ref : Journal of Pharmacology & Experimental Therapeutics , 313 :1011 , 2005 |
Abstract : |
PubMedSearch : Quinney_2005_J.Pharmacol.Exp.Ther_313_1011 |
PubMedID: 15687373 |
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 |
Title : Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3 - Sanghani_2004_Drug.Metab.Dispos_32_505 |
Author(s) : Sanghani SP , Quinney SK , Fredenburg TB , Davis WI , Murry DJ , Bosron WF |
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 32 :505 , 2004 |
Abstract : |
PubMedSearch : Sanghani_2004_Drug.Metab.Dispos_32_505 |
PubMedID: 15100172 |
Gene_locus related to this paper: human-CES2 , human-CES3 |
Title : The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment - Clark_2003_Genome.Res_13_2265 |
Author(s) : Clark HF , Gurney AL , Abaya E , Baker K , Baldwin D , Brush J , Chen J , Chow B , Chui C , Crowley C , Currell B , Deuel B , Dowd P , Eaton D , Foster J , Grimaldi C , Gu Q , Hass PE , Heldens S , Huang A , Kim HS , Klimowski L , Jin Y , Johnson S , Lee J , Lewis L , Liao D , Mark M , Robbie E , Sanchez C , Schoenfeld J , Seshagiri S , Simmons L , Singh J , Smith V , Stinson J , Vagts A , Vandlen R , Watanabe C , Wieand D , Woods K , Xie MH , Yansura D , Yi S , Yu G , Yuan J , Zhang M , Zhang Z , Goddard A , Wood WI , Godowski P , Gray A |
Ref : Genome Res , 13 :2265 , 2003 |
Abstract : |
PubMedSearch : Clark_2003_Genome.Res_13_2265 |
PubMedID: 12975309 |
Gene_locus related to this paper: human-CES3 , human-CES4A |
Title : Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis - Sanghani_2003_Clin.Cancer.Res_9_4983 |
Author(s) : Sanghani SP , Quinney SK , Fredenburg TB , Sun Z , Davis WI , Murry DJ , Cummings OW , Seitz DE , Bosron WF |
Ref : Clin Cancer Research , 9 :4983 , 2003 |
Abstract : |
PubMedSearch : Sanghani_2003_Clin.Cancer.Res_9_4983 |
PubMedID: 14581373 |
Gene_locus related to this paper: human-CES3 |