mouse-Ces1d

Mus musculus (Mouse) triacylglycerol hydrolase (tgh) Fatty acid ethyl ester synthase Carboxylesterase 3 (EC 3.1.1.1)

Comment

old human-hBr3 Genbank AB025028 Mori et al. WARNING this human sequence in database is soo close to mouse-Ces1d, not found in genome so is it a contamination or a file error? The human ortholog of mouse Ces3\/TGH\/Ces1d is CES1

Relationship

Family : Carb_B_Chordata

Block : C

Position in NCBI Life Tree : Mus musculus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

Database

Sequence

Peptide

MRLYPLIWLS LAACTAWGYP SSPPVVNTVK GKVLGKYVNL EGFTQPVAVF LGVPFAKPPL GSLRFAPPQP AEPWSFVKNT TSYPPMCSQD AVGGQVLSEL FTNRKENIPL QFSEDCLYLN IYTPADLTKN SRLPVMVWIH GGGLVVGGAS TYDGLALSAH ENVVVVTIQY RLGIWGFFST GDEHSRGNWG HLDQVAALRW VQDNIANFGG NPGSVTIFGE SAGGFSVSVL VLSPLAKNLF HRAISESGVS LTAALITTDV KPIAGLVATL SGCKTTTSAV MVHCLRQKTE DELLETSLKL NLFKLDLLGN PKESYPFLPT VIDGVVLPKA PEEILAEKSF STVPYIVGIN KQEFGWIIPT LMGYPLAEGK LDQKTANSLL WKSYPTLKIS ENMIPVVAEK YLGGTDDLTK KKDLFQDLMA DVVFGVPSVI VSRSHRDAGA STYMYEFEYR PSFVSAMRPK AVIGDHGDEI FSVFGSPFLK DGASEEETNL SKMVMKFWAN FARNGNPNGG GLPHWPEYDQ KEGYLKIGAS TQAAQRLKDK EVSFWAELRA KESAQRPSHR EHVEL

References (16)

Title : Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism - Gan_2023_Acta.Pharm.Sin.B_13_618
Author(s) : Gan C , Wang J , Martinez-Chavez A , Hillebrand M , de Vries N , Beukers J , Wagenaar E , Wang Y , Lebre MC , Rosing H , Klarenbeek S , Ali RB , Pritchard C , Huijbers I , Beijnen JH , Schinkel AH
Ref : Acta Pharm Sin B , 13 :618 , 2023
PubMedID: 36873183
Gene_locus related to this paper: mouse-Ces1a , mouse-Ces1b , mouse-Ces1c , mouse-Ces1d , mouse-Ces1e , mouse-Ces1f , mouse-Ces1g , mouse-Ces1h

Title : Natural deletion of mouse carboxylesterases Ces1c\/d\/e impacts drug metabolism and metabolic syndrome development - Gan_2023_Biomed.Pharmacother_164_114956
Author(s) : Gan C , Wang J , Wang Y , Martinez-Chavez A , Hillebrand M , de Vries N , Beukers J , Lebre MC , Wagenaar E , Rosing H , Klarenbeek S , Bleijerveld OB , Song JY , Altelaar M , Beijnen JH , Schinkel AH
Ref : Biomed Pharmacother , 164 :114956 , 2023
PubMedID: 37267638
Gene_locus related to this paper: human-CES1 , mouse-Ces1c , mouse-Ces1d , mouse-Ces1e

Title : Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice - Li_2022_Life.Sci.Alliance_5_
Author(s) : Li G , Li X , Yang L , Wang S , Dai Y , Fekry B , Veillon L , Tan L , Berdeaux R , Eckel-Mahan K , Lorenzi PL , Zhao Z , Lehner R , Sun K
Ref : Life Sciences Alliance , 5 : , 2022
PubMedID: 35459739
Gene_locus related to this paper: mouse-Ces1d

Title : Carboxylesterase 1d (Ces1d) does not contribute to cholesteryl ester hydrolysis in the liver - Lian_2021_J.Lipid.Res__100093
Author(s) : Lian J , van der Veen JN , Watts R , Jacobs RL , Lehner R
Ref : J Lipid Res , :100093 , 2021
PubMedID: 34153284
Gene_locus related to this paper: mouse-Ces1d

Title : Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation - Lian_2019_J.Lipid.Res_60_880
Author(s) : Lian J , Watts R , Quiroga AD , Beggs MR , Alexander RT , Lehner R
Ref : J Lipid Res , 60 :880 , 2019
PubMedID: 30737251
Gene_locus related to this paper: mouse-Ces1d

Title : A Unique Role of Carboxylesterase 3 (Ces3) in beta-Adrenergic Signaling-Stimulated Thermogenesis - Yang_2019_Diabetes_68_1178
Author(s) : Yang L , Li X , Tang H , Gao Z , Zhang K , Sun K
Ref : Diabetes , 68 :1178 , 2019
PubMedID: 30862682
Gene_locus related to this paper: human-CES3 , mouse-Ces1d

Title : Ces3\/TGH Deficiency Attenuates Steatohepatitis - Lian_2016_Sci.Rep_6_25747
Author(s) : Lian J , Wei E , Groenendyk J , Das SK , Hermansson M , Li L , Watts R , Thiesen A , Oudit GY , Michalak M , Lehner R
Ref : Sci Rep , 6 :25747 , 2016
PubMedID: 27181051
Gene_locus related to this paper: mouse-Ces1d

Title : Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes - Dominguez_2014_Nat.Chem.Biol_10_113
Author(s) : Dominguez E , Galmozzi A , Chang JW , Hsu KL , Pawlak J , Li W , Godio C , Thomas J , Partida D , Niessen S , O'Brien PE , Russell AP , Watt MJ , Nomura DK , Cravatt BF , Saez E
Ref : Nat Chemical Biology , 10 :113 , 2014
PubMedID: 24362705
Gene_locus related to this paper: human-CES3 , mouse-Ces1d

Title : Liver-specific cholesteryl ester hydrolase deficiency attenuates sterol elimination in the feces and increases atherosclerosis in ldlr-\/- mice - Bie_2013_Arterioscler.Thromb.Vasc.Biol_33_1795
Author(s) : Bie J , Wang J , Marqueen KE , Osborne R , Kakiyama G , Korzun W , Ghosh SS , Ghosh S
Ref : Arterioscler Thromb Vasc Biol , 33 :1795 , 2013
PubMedID: 23744992
Gene_locus related to this paper: mouse-Ces1d

Title : Ces3\/TGH deficiency improves dyslipidemia and reduces atherosclerosis in Ldlr(-\/-) mice - Lian_2012_Circ.Res_111_982
Author(s) : Lian J , Quiroga AD , Li L , Lehner R
Ref : Circulation Research , 111 :982 , 2012
PubMedID: 22872154
Gene_locus related to this paper: mouse-Ces1d

Title : Isolation and characterization of a microsomal acid retinyl ester hydrolase - Linke_2005_J.Biol.Chem_280_23287
Author(s) : Linke T , Dawson H , Harrison EH
Ref : Journal of Biological Chemistry , 280 :23287 , 2005
PubMedID: 15767260
Gene_locus related to this paper: mouse-Ces1d , ratno-Ces1d

Title : Identification of di-(2-ethylhexyl) phthalate-induced carboxylesterase 1 in C57BL\/6 mouse liver microsomes: purification, cDNA cloning, and baculovirus-mediated expression - Furihata_2004_Drug.Metab.Dispos_32_1170
Author(s) : Furihata T , Hosokawa M , Koyano N , Nakamura T , Satoh T , Chiba K
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 32 :1170 , 2004
PubMedID: 15269189
Gene_locus related to this paper: mouse-Ces1d

Title : Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase - Soni_2004_J.Biol.Chem_279_40683
Author(s) : Soni KG , Lehner R , Metalnikov P , O'Donnell P , Semache M , Gao W , Ashman K , Pshezhetsky AV , Mitchell GA
Ref : Journal of Biological Chemistry , 279 :40683 , 2004
PubMedID: 15220344
Gene_locus related to this paper: mouse-Ces1d

Title : Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs - Okazaki_2002_Nature_420_563
Author(s) : Okazaki Y , Furuno M , Kasukawa T , Adachi J , Bono H , Kondo S , Nikaido I , Osato N , Saito R , Suzuki H , Yamanaka I , Kiyosawa H , Yagi K , Tomaru Y , Hasegawa Y , Nogami A , Schonbach C , Gojobori T , Baldarelli R , Hill DP , Bult C , Hume DA , Quackenbush J , Schriml LM , Kanapin A , Matsuda H , Batalov S , Beisel KW , Blake JA , Bradt D , Brusic V , Chothia C , Corbani LE , Cousins S , Dalla E , Dragani TA , Fletcher CF , Forrest A , Frazer KS , Gaasterland T , Gariboldi M , Gissi C , Godzik A , Gough J , Grimmond S , Gustincich S , Hirokawa N , Jackson IJ , Jarvis ED , Kanai A , Kawaji H , Kawasawa Y , Kedzierski RM , King BL , Konagaya A , Kurochkin IV , Lee Y , Lenhard B , Lyons PA , Maglott DR , Maltais L , Marchionni L , McKenzie L , Miki H , Nagashima T , Numata K , Okido T , Pavan WJ , Pertea G , Pesole G , Petrovsky N , Pillai R , Pontius JU , Qi D , Ramachandran S , Ravasi T , Reed JC , Reed DJ , Reid J , Ring BZ , Ringwald M , Sandelin A , Schneider C , Semple CA , Setou M , Shimada K , Sultana R , Takenaka Y , Taylor MS , Teasdale RD , Tomita M , Verardo R , Wagner L , Wahlestedt C , Wang Y , Watanabe Y , Wells C , Wilming LG , Wynshaw-Boris A , Yanagisawa M , Yang I , Yang L , Yuan Z , Zavolan M , Zhu Y , Zimmer A , Carninci P , Hayatsu N , Hirozane-Kishikawa T , Konno H , Nakamura M , Sakazume N , Sato K , Shiraki T , Waki K , Kawai J , Aizawa K , Arakawa T , Fukuda S , Hara A , Hashizume W , Imotani K , Ishii Y , Itoh M , Kagawa I , Miyazaki A , Sakai K , Sasaki D , Shibata K , Shinagawa A , Yasunishi A , Yoshino M , Waterston R , Lander ES , Rogers J , Birney E , Hayashizaki Y
Ref : Nature , 420 :563 , 2002
PubMedID: 12466851
Gene_locus related to this paper: mouse-1lipg , mouse-1llip , mouse-1plrp , mouse-3neur , mouse-ABH15 , mouse-abhd4 , mouse-abhd5 , mouse-Abhd8 , mouse-Abhd11 , mouse-abhda , mouse-acot4 , mouse-adcl4 , mouse-AI607300 , mouse-BAAT , mouse-bphl , mouse-C87498 , mouse-Ldah , mouse-Ces1d , mouse-Ces2e , mouse-CMBL , mouse-DGLB , mouse-dpp9 , mouse-ES10 , mouse-F135A , mouse-FASN , mouse-hslip , mouse-hyes , mouse-Kansl3 , mouse-LIPH , mouse-LIPK , mouse-lipli , mouse-LIPM , mouse-lypla1 , mouse-lypla2 , mouse-MEST , mouse-MGLL , mouse-ndr4 , mouse-OVCA2 , mouse-pafa , mouse-pcp , mouse-ppce , mouse-Ppgb , mouse-PPME1 , mouse-q3uuq7 , mouse-Q8BLF1 , mouse-ACOT6 , mouse-Q8C1A9 , mouse-Q9DAI6 , mouse-Q80UX8 , mouse-Q8BGG9 , mouse-Q8C167 , mouse-rbbp9 , mouse-SERHL , mouse-tssp

Title : The cloning and expression of a murine triacylglycerol hydrolase cDNA and the structure of its corresponding gene - Dolinsky_2001_Biochim.Biophys.Acta_1532_162
Author(s) : Dolinsky VW , Sipione S , Lehner R , Vance DE
Ref : Biochimica & Biophysica Acta , 1532 :162 , 2001
PubMedID: 11470237
Gene_locus related to this paper: mouse-Ces1d

Title : cDNA cloning, characterization and stable expression of novel human brain carboxylesterase - Mori_1999_FEBS.Lett_458_17
Author(s) : Mori M , Hosokawa M , Ogasawara Y , Tsukada E , Chiba K
Ref : FEBS Letters , 458 :17 , 1999
PubMedID: 10518925
Gene_locus related to this paper: human-CES1 , mouse-Ces1d