Gene Locus : human-CES1
Mode of mutation : Natural mutant || Site directed mutagenesis
Disease :
Summary : Expression Low activity or expression Zhu_2008_Am.J.Hum.Genet_82_1241 || Expression increased clopidogrel active metabolite levels and greater clopidogrel response Lewis_2013_Pharmacogenet.Genomics_23_1 || Expression activation of the antiviral prodrug oseltamivir is impaired Zhu_2009_Drug.Metab.Dispos_37_264 || Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender Shi_2016_Biochem.Pharmacol_119_76 || Enalapril activation is affected by the CES1 genetic polymorphism G143E (rs71647871) Ikonnikova_2022_J.Pers.Med_12_580
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity : CES-1 deficiency
Modification : Expression
Torpedo_number : 119
Kinetic Parameter : No kinetic parameter
News : MAY-20-2008
Comment :
p.G143E Gly143Glu c.428G>A (rs71647871)
| Title : Impact of genetic polymorphisms and drug-drug interactions mediated by carboxylesterase 1 on remimazolam deactivation - Wang_2025_Drug.Metab.Dispos_53_100023 |
| Author(s) : Wang Z , McCalla Z , Lin L , Tornichio D , Agyemang Y , Bastulli JA , Zhang XS , Zhu HJ , Wang X |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 53 :100023 , 2025 |
| Abstract : |
| PubMedSearch : Wang_2025_Drug.Metab.Dispos_53_100023 |
| PubMedID: 39884809 |
| Gene_locus related to this paper: human-CES1 |
| Title : Randomized evaluation of the loss-of-function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics - Lewis_2024_Clin.Transl.Sci_17_e70079 |
| Author(s) : Lewis JP , Ryan KA , Streeten EA , Whitlatch HB , Daue M , Tanner K , Perry JA , O'Connell JR , Shuldiner AR , Mitchell BD |
| Ref : Clin Transl Sci , 17 :e70079 , 2024 |
| Abstract : |
| PubMedSearch : Lewis_2024_Clin.Transl.Sci_17_e70079 |
| PubMedID: 39576732 |
| Title : Pharmacogenetic study of CES1 gene and enalapril efficacy - Hussain_2024_J.Appl.Genet__ |
| Author(s) : Hussain M , Basheer S , Khalil A , Haider QUA , Saeed H , Faizan M |
| Ref : J Appl Genet , : , 2024 |
| Abstract : |
| PubMedSearch : Hussain_2024_J.Appl.Genet__ |
| PubMedID: 38261266 |
| Gene_locus related to this paper: human-CES1 |
| Title : Major implications of single nucleotide polymorphisms in human carboxylesterase 1 on substrate bioavailability - Yerrakula_2022_Biotechnol.Genet.Eng.Rev__ |
| Author(s) : Yerrakula G , Abraham S , John S , Zeharvi M , George SG , Senthil V , Maiz F , Rahman MH |
| Ref : Biotechnol Genet Eng Rev , :1 , 2022 |
| Abstract : |
| PubMedSearch : Yerrakula_2022_Biotechnol.Genet.Eng.Rev__ |
| PubMedID: 35946821 |
| Gene_locus related to this paper: human-CES1 |
| Title : The Influence of the CES1 Genotype on the Pharmacokinetics of Enalapril in Patients with Arterial Hypertension - Ikonnikova_2022_J.Pers.Med_12_580 |
| Author(s) : Ikonnikova A , Rodina T , Dmitriev A , Melnikov E , Kazakov R , Nasedkina T |
| Ref : J Pers Med , 12 : , 2022 |
| Abstract : |
| PubMedSearch : Ikonnikova_2022_J.Pers.Med_12_580 |
| PubMedID: 35455696 |
| Gene_locus related to this paper: human-CES1 |
| Title : The influence of carboxylesterase 1 polymorphism and cannabidiol on the hepatic metabolism of heroin - Qian_2019_Chem.Biol.Interact__108914 |
| Author(s) : Qian Y , Gilliland TK , Markowitz JS |
| Ref : Chemico-Biological Interactions , :108914 , 2019 |
| Abstract : |
| PubMedSearch : Qian_2019_Chem.Biol.Interact__108914 |
| PubMedID: 31837295 |
| Title : The impact of human CES1 genetic variation on enzyme activity assessed by ritalinic acid\/methylphenidate ratios - Stage_2019_Basic.Clin.Pharmacol.Toxicol_125_54 |
| Author(s) : Stage C , Dalhoff K , Rasmussen HB , Schow Guski L , Thomsen R , Bjerre D , Ferrero-Miliani L , Busk Madsen M , Jurgens G |
| Ref : Basic Clin Pharmacol Toxicol , 125 :54 , 2019 |
| Abstract : |
| PubMedSearch : Stage_2019_Basic.Clin.Pharmacol.Toxicol_125_54 |
| PubMedID: 30801959 |
| Gene_locus related to this paper: human-CES1 |
| Title : Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects - Neuvonen_2018_Basic.Clin.Pharmacol.Toxicol_122_341 |
| Author(s) : Neuvonen M , Tarkiainen EK , Tornio A , Hirvensalo P , Tapaninen T , Paile-Hyvarinen M , Itkonen MK , Holmberg MT , Karja V , Mannisto VT , Neuvonen PJ , Pihlajamaki J , Backman JT , Niemi M |
| Ref : Basic Clin Pharmacol Toxicol , 122 :341 , 2018 |
| Abstract : |
| PubMedSearch : Neuvonen_2018_Basic.Clin.Pharmacol.Toxicol_122_341 |
| PubMedID: 28990360 |
| Gene_locus related to this paper: human-CES1 |
| Title : Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis - Lian_2018_Biochim.Biophys.Acta_1863_688 |
| Author(s) : Lian J , Bahitham W , Panigrahi R , Nelson R , Li L , Watts R , Thiesen A , Lemieux MJ , Lehner R |
| Ref : Biochimica & Biophysica Acta , 1863 :688 , 2018 |
| Abstract : |
| PubMedSearch : Lian_2018_Biochim.Biophys.Acta_1863_688 |
| PubMedID: 29631096 |
| Gene_locus related to this paper: human-CES1 |
| Title : The impact of CES1 genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects - Stage_2017_Br.J.Clin.Pharmacol_83_1506 |
| Author(s) : Stage C , Jurgens G , Guski LS , Thomsen R , Bjerre D , Ferrero-Miliani L , Lyauk YK , Rasmussen HB , Dalhoff K |
| Ref : British Journal of Clinical Pharmacology , 83 :1506 , 2017 |
| Abstract : |
| PubMedSearch : Stage_2017_Br.J.Clin.Pharmacol_83_1506 |
| PubMedID: 28087982 |
| Gene_locus related to this paper: human-CES1 |
| Title : Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender - Shi_2016_Biochem.Pharmacol_119_76 |
| Author(s) : Shi J , Wang X , Nguyen JH , Bleske BE , Liang Y , Liu L , Zhu HJ |
| Ref : Biochemical Pharmacology , 119 :76 , 2016 |
| Abstract : |
| PubMedSearch : Shi_2016_Biochem.Pharmacol_119_76 |
| PubMedID: 27614009 |
| Gene_locus related to this paper: human-CES1 |
| Title : Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms - Shi_2016_Basic.Clin.Pharmacol.Toxicol_119_555 |
| Author(s) : Shi J , Wang X , Eyler RF , Liang Y , Liu L , Mueller BA , Zhu HJ |
| Ref : Basic Clin Pharmacol Toxicol , 119 :555 , 2016 |
| Abstract : |
| PubMedSearch : Shi_2016_Basic.Clin.Pharmacol.Toxicol_119_555 |
| PubMedID: 27228223 |
| Gene_locus related to this paper: human-CES1 |
| Title : CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors - Wang_2016_Pharmacogenomics.J_16_220 |
| Author(s) : Wang X , Wang G , Shi J , Aa JY , Comas R , Liang Y , Zhu HJ |
| Ref : Pharmacogenomics J , 16 :220 , 2016 |
| Abstract : |
| PubMedSearch : Wang_2016_Pharmacogenomics.J_16_220 |
| PubMedID: 26076923 |
| Gene_locus related to this paper: human-CES1 |
| Title : Investigating the impact of missense mutations in hCES1 by in silico structure-based approaches - Nzabonimpa_2016_Drug.Metab.Pers.Ther__ |
| Author(s) : Nzabonimpa GS , Rasmussen HB , Brunak S , Taboureau O |
| Ref : Drug Metab Pers Ther , : , 2016 |
| Abstract : |
| PubMedSearch : Nzabonimpa_2016_Drug.Metab.Pers.Ther__ |
| PubMedID: 26900165 |
| Gene_locus related to this paper: human-CES1 |
| Title : Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 (CES1) Variants - Lyauk_2016_Clin.Transl.Sci_9_337 |
| Author(s) : Lyauk YK , Stage C , Bergmann TK , Ferrero-Milliani L , Bjerre D , Thomsen R , Dalhoff KP , Rasmussen HB , Jurgens G |
| Ref : Clin Transl Sci , 9 :337 , 2016 |
| Abstract : |
| PubMedSearch : Lyauk_2016_Clin.Transl.Sci_9_337 |
| PubMedID: 27754602 |
| Gene_locus related to this paper: human-CES1 |
| Title : Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation - Shi_2016_Drug.Metab.Dispos_44_554 |
| Author(s) : Shi J , Wang X , Nguyen J , Wu AH , Bleske BE , Zhu HJ |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 44 :554 , 2016 |
| Abstract : |
| PubMedSearch : Shi_2016_Drug.Metab.Dispos_44_554 |
| PubMedID: 26817948 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1 c.428G>\;A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans - Tarkiainen_2015_Clin.Pharmacol.Ther_97_650 |
| Author(s) : Tarkiainen EK , Holmberg MT , Tornio A , Neuvonen M , Neuvonen PJ , Backman JT , Niemi M |
| Ref : Clinical Pharmacology & Therapeutics , 97 :650 , 2015 |
| Abstract : |
| PubMedSearch : Tarkiainen_2015_Clin.Pharmacol.Ther_97_650 |
| PubMedID: 25704243 |
| Gene_locus related to this paper: human-CES1 |
| Title : Effect of carboxylesterase 1 c.428G >\; A single nucleotide variation on the pharmacokinetics of quinapril and enalapril - Tarkiainen_2015_Br.J.Clin.Pharmacol_80_1131 |
| Author(s) : Tarkiainen EK , Tornio A , Holmberg MT , Launiainen T , Neuvonen PJ , Backman JT , Niemi M |
| Ref : British Journal of Clinical Pharmacology , 80 :1131 , 2015 |
| Abstract : |
| PubMedSearch : Tarkiainen_2015_Br.J.Clin.Pharmacol_80_1131 |
| PubMedID: 25919042 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation - Zhu_2013_J.Pharmacol.Exp.Ther_344_665 |
| Author(s) : Zhu HJ , Wang X , Gawronski BE , Brinda BJ , Angiolillo DJ , Markowitz JS |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 344 :665 , 2013 |
| Abstract : |
| PubMedSearch : Zhu_2013_J.Pharmacol.Exp.Ther_344_665 |
| PubMedID: 23275066 |
| Gene_locus related to this paper: human-CES1 |
| Title : The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response - Lewis_2013_Pharmacogenet.Genomics_23_1 |
| Author(s) : Lewis JP , Horenstein RB , Ryan K , O'Connell JR , Gibson Q , Mitchell BD , Tanner K , Chai S , Bliden KP , Tantry US , Peer CJ , Figg WD , Spencer SD , Pacanowski MA , Gurbel PA , Shuldiner AR |
| Ref : Pharmacogenet Genomics , 23 :1 , 2013 |
| Abstract : |
| PubMedSearch : Lewis_2013_Pharmacogenet.Genomics_23_1 |
| PubMedID: 23111421 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1 polymorphism impairs oseltamivir bioactivation in humans - Tarkiainen_2012_Clin.Pharmacol.Ther_92_68 |
| Author(s) : Tarkiainen EK , Backman JT , Neuvonen M , Neuvonen PJ , Schwab M , Niemi M |
| Ref : Clinical Pharmacology & Therapeutics , 92 :68 , 2012 |
| Abstract : |
| PubMedSearch : Tarkiainen_2012_Clin.Pharmacol.Ther_92_68 |
| PubMedID: 22588607 |
| Gene_locus related to this paper: human-CES1 |
| Title : A simple allele-specific polymerase chain reaction method to detect the Gly143Glu polymorphism in the human carboxylesterase 1 gene: importance of genotyping for pharmacogenetic treatment - Walter_2010_Genet.Test.Mol.Biomarkers_14_749 |
| Author(s) : Walter Soria N , Belaus A , Galvan C , Ana Pasquali M , Velez P , Del Carmen Montes C , Beltramo DM |
| Ref : Genet Test Mol Biomarkers , 14 :749 , 2010 |
| Abstract : |
| PubMedSearch : Walter_2010_Genet.Test.Mol.Biomarkers_14_749 |
| PubMedID: 20858053 |
| Title : Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD - Nemoda_2009_Neuropharmacol_57_731 |
| Author(s) : Nemoda Z , Angyal N , Tarnok Z , Gadoros J , Sasvari-Szekely M |
| Ref : Neuropharmacology , 57 :731 , 2009 |
| Abstract : |
| PubMedSearch : Nemoda_2009_Neuropharmacol_57_731 |
| PubMedID: 19733552 |
| Gene_locus related to this paper: human-CES1 |
| Title : Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants - Zhu_2009_Drug.Metab.Dispos_37_264 |
| Author(s) : Zhu HJ , Markowitz JS |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 37 :264 , 2009 |
| Abstract : |
| PubMedSearch : Zhu_2009_Drug.Metab.Dispos_37_264 |
| PubMedID: 19022936 |
| Gene_locus related to this paper: human-CES1 |
| Title : Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis - Zhu_2008_Am.J.Hum.Genet_82_1241 |
| Author(s) : Zhu HJ , Patrick KS , Yuan HJ , Wang JS , Donovan JL , DeVane CL , Malcolm R , Johnson JA , Youngblood GL , Sweet DH , Langaee TY , Markowitz JS |
| Ref : American Journal of Human Genetics , 82 :1241 , 2008 |
| Abstract : |
| PubMedSearch : Zhu_2008_Am.J.Hum.Genet_82_1241 |
| PubMedID: 18485328 |
| Gene_locus related to this paper: human-CES1 |