Lehner R

References (47)

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Author(s) : Park SH , Seo W , Xu MJ , Mackowiak B , Lin Y , He Y , Fu Y , Hwang S , Kim SJ , Guan Y , Feng D , Yu L , Lehner R , Liangpunsakul S , Gao B
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Title : Carboxylesterase 1d Inactivation Augments Lung Inflammation in Mice - Szafran_2022_ACS.Pharmacol.Transl.Sci_5_919
Author(s) : Szafran BN , Borazjani A , Scheaffer HL , Crow JA , McBride AM , Adekanye O , Wonnacott CB , Lehner R , Kaplan BLF , Ross MK
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Title : Interfering with lipid metabolism through targeting CES1 sensitizes hepatocellular carcinoma for chemotherapy - Li_2022_JCI.Insight__
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PubMedSearch : Li_2022_JCI.Insight__
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Title : Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice - Li_2022_Life.Sci.Alliance_5_
Author(s) : Li G , Li X , Yang L , Wang S , Dai Y , Fekry B , Veillon L , Tan L , Berdeaux R , Eckel-Mahan K , Lorenzi PL , Zhao Z , Lehner R , Sun K
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Gene_locus related to this paper: mouse-Ces1d

Title : Effects of Chlorpyrifos on Serine Hydrolase Activities, Lipid Mediators, and Immune Responses in Lungs of Neonatal and Adult Mice - Szafran_2021_Chem.Res.Toxicol__
Author(s) : Szafran BN , Borazjani A , Seay CN , Carr RL , Lehner R , Kaplan BLF , Ross MK
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Title : Carboxylesterase 1d (Ces1d) does not contribute to cholesteryl ester hydrolysis in the liver - Lian_2021_J.Lipid.Res__100093
Author(s) : Lian J , van der Veen JN , Watts R , Jacobs RL , Lehner R
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PubMedSearch : Lian_2021_J.Lipid.Res__100093
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Gene_locus related to this paper: mouse-Ces1d

Title : Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation - Lian_2019_J.Lipid.Res_60_880
Author(s) : Lian J , Watts R , Quiroga AD , Beggs MR , Alexander RT , Lehner R
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PubMedSearch : Lian_2019_J.Lipid.Res_60_880
PubMedID: 30737251
Gene_locus related to this paper: mouse-Ces1d

Title : Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis - Lian_2018_Biochim.Biophys.Acta_1863_688
Author(s) : Lian J , Bahitham W , Panigrahi R , Nelson R , Li L , Watts R , Thiesen A , Lemieux MJ , Lehner R
Ref : Biochimica & Biophysica Acta , 1863 :688 , 2018
Abstract :
PubMedSearch : Lian_2018_Biochim.Biophys.Acta_1863_688
PubMedID: 29631096
Gene_locus related to this paper: human-CES1

Title : Pharmacological intervention of liver triacylglycerol lipolysis: The good, the bad and the ugly - Quiroga_2018_Biochem.Pharmacol_155_233
Author(s) : Quiroga AD , Lehner R
Ref : Biochemical Pharmacology , 155 :233 , 2018
Abstract :
PubMedSearch : Quiroga_2018_Biochem.Pharmacol_155_233
PubMedID: 30006193

Title : Carboxylesterases in lipid metabolism: from mouse to human - Lian_2018_Protein.Cell_9_178
Author(s) : Lian J , Nelson R , Lehner R
Ref : Protein Cell , 9 :178 , 2018
Abstract :
PubMedSearch : Lian_2018_Protein.Cell_9_178
PubMedID: 28677105
Gene_locus related to this paper: human-CES1

Title : Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation - Lord_2016_Cell.Rep_16_939
Author(s) : Lord CC , Ferguson D , Thomas G , Brown AL , Schugar RC , Burrows A , Gromovsky AD , Betters J , Neumann C , Sacks J , Marshall S , Watts R , Schweiger M , Lee RG , Crooke RM , Graham MJ , Lathia JD , Sakaguchi TF , Lehner R , Haemmerle G , Zechner R , Brown JM
Ref : Cell Rep , 16 :939 , 2016
Abstract :
PubMedSearch : Lord_2016_Cell.Rep_16_939
PubMedID: 27396333

Title : Ces3\/TGH Deficiency Attenuates Steatohepatitis - Lian_2016_Sci.Rep_6_25747
Author(s) : Lian J , Wei E , Groenendyk J , Das SK , Hermansson M , Li L , Watts R , Thiesen A , Oudit GY , Michalak M , Lehner R
Ref : Sci Rep , 6 :25747 , 2016
Abstract :
PubMedSearch : Lian_2016_Sci.Rep_6_25747
PubMedID: 27181051
Gene_locus related to this paper: mouse-Ces1d

Title : Liver-specific expression of carboxylesterase 1g\/esterase-x reduces hepatic steatosis, counteracts dyslipidemia and improves insulin signaling - Bahitham_2016_Biochim.Biophys.Acta_1861_482
Author(s) : Bahitham W , Watts R , Nelson R , Lian J , Lehner R
Ref : Biochimica & Biophysica Acta , 1861 :482 , 2016
Abstract :
PubMedSearch : Bahitham_2016_Biochim.Biophys.Acta_1861_482
PubMedID: 26976727
Gene_locus related to this paper: mouse-Ces1g

Title : Endoplasmic reticulum-localized hepatic lipase decreases triacylglycerol storage and VLDL secretion - Erickson_2013_Biochim.Biophys.Acta_1831_1113
Author(s) : Erickson B , Selvan SP , Ko KW , Kelly K , Quiroga AD , Li L , Nelson R , King-Jones K , Jacobs RL , Lehner R
Ref : Biochimica & Biophysica Acta , 1831 :1113 , 2013
Abstract :
PubMedSearch : Erickson_2013_Biochim.Biophys.Acta_1831_1113
PubMedID: 23376223

Title : Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production - Nourbakhsh_2013_J.Hepatol_59_336
Author(s) : Nourbakhsh M , Douglas DN , Pu CH , Lewis JT , Kawahara T , Lisboa LF , Wei E , Asthana S , Quiroga AD , Law LM , Chen C , Addison WR , Nelson R , Houghton M , Lehner R , Kneteman NM
Ref : Journal of Hepatology , 59 :336 , 2013
Abstract :
PubMedSearch : Nourbakhsh_2013_J.Hepatol_59_336
PubMedID: 23542347
Gene_locus related to this paper: human-AADAC

Title : Liver triacylglycerol lipases - Quiroga_2012_Biochim.Biophys.Acta_1821_762
Author(s) : Quiroga AD , Lehner R
Ref : Biochimica & Biophysica Acta , 1821 :762 , 2012
Abstract :
PubMedSearch : Quiroga_2012_Biochim.Biophys.Acta_1821_762
PubMedID: 21963564

Title : Carboxylesterase1\/Esterase-x Regulates Chylomicron Production in Mice - Quiroga_2012_PLoS.One_7_e49515
Author(s) : Quiroga AD , Lian J , Lehner R
Ref : PLoS ONE , 7 :e49515 , 2012
Abstract :
PubMedSearch : Quiroga_2012_PLoS.One_7_e49515
PubMedID: 23145182

Title : Deficiency of carboxylesterase 1\/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia - Quiroga_2012_Hepatology_56_2188
Author(s) : Quiroga AD , Li L , Trotzmuller M , Nelson R , Proctor SD , Kofeler H , Lehner R
Ref : Hepatology , 56 :2188 , 2012
Abstract :
PubMedSearch : Quiroga_2012_Hepatology_56_2188
PubMedID: 22806626
Gene_locus related to this paper: mouse-Ces1c , mouse-Ces1g

Title : Ces3\/TGH deficiency improves dyslipidemia and reduces atherosclerosis in Ldlr(-\/-) mice - Lian_2012_Circ.Res_111_982
Author(s) : Lian J , Quiroga AD , Li L , Lehner R
Ref : Circulation Research , 111 :982 , 2012
Abstract :
PubMedSearch : Lian_2012_Circ.Res_111_982
PubMedID: 22872154
Gene_locus related to this paper: mouse-Ces1d

Title : Liver specific inactivation of carboxylesterase 3\/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice - Lian_2012_Hepatology_56_2154
Author(s) : Lian J , Wei E , Wang SP , Quiroga AD , Li L , Pardo AD , van der Veen J , Sipione S , Mitchell GA , Lehner R , Di Pardo A
Ref : Hepatology , 56 :2154 , 2012
Abstract :
PubMedSearch : Lian_2012_Hepatology_56_2154
PubMedID: 22707181

Title : Role of endoplasmic reticulum neutral lipid hydrolases - Quiroga_2011_Trends.Endocrinol.Metab_22_218
Author(s) : Quiroga AD , Lehner R
Ref : Trends Endocrinol Metab , 22 :218 , 2011
Abstract :
PubMedSearch : Quiroga_2011_Trends.Endocrinol.Metab_22_218
PubMedID: 21531146

Title : Altered lipid droplet dynamics in hepatocytes lacking triacylglycerol hydrolase expression - Wang_2010_Mol.Biol.Cell_21_1991
Author(s) : Wang H , Wei E , Quiroga AD , Sun X , Touret N , Lehner R
Ref : Mol Biology of the cell , 21 :1991 , 2010
Abstract :
PubMedSearch : Wang_2010_Mol.Biol.Cell_21_1991
PubMedID: 20410140

Title : Loss of TGH\/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure - Wei_2010_Cell.Metab_11_183
Author(s) : Wei E , Ben Ali Y , Lyon J , Wang H , Nelson R , Dolinsky VW , Dyck JR , Mitchell G , Korbutt GS , Lehner R
Ref : Cell Metab , 11 :183 , 2010
Abstract :
PubMedSearch : Wei_2010_Cell.Metab_11_183
PubMedID: 20197051

Title : Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins - Holmes_2010_Mamm.Genome_21_427
Author(s) : Holmes RS , Wright MW , Laulederkind SJ , Cox LA , Hosokawa M , Imai T , Ishibashi S , Lehner R , Miyazaki M , Perkins EJ , Potter PM , Redinbo MR , Robert J , Satoh T , Yamashita T , Yan B , Yokoi T , Zechner R , Maltais LJ
Ref : Mamm Genome , 21 :427 , 2010
Abstract :
PubMedSearch : Holmes_2010_Mamm.Genome_21_427
PubMedID: 20931200
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A

Title : Arylacetamide deacetylase attenuates fatty-acid-induced triacylglycerol accumulation in rat hepatoma cells - Lo_2010_J.Lipid.Res_51_368
Author(s) : Lo V , Erickson B , Thomason-Hughes M , Ko KW , Dolinsky VW , Nelson R , Lehner R
Ref : J Lipid Res , 51 :368 , 2010
Abstract :
PubMedSearch : Lo_2010_J.Lipid.Res_51_368
PubMedID: 19654421
Gene_locus related to this paper: mouse-aryla

Title : Es-x\/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes - Ko_2009_Biochim.Biophys.Acta_1791_1133
Author(s) : Ko KW , Erickson B , Lehner R
Ref : Biochimica & Biophysica Acta , 1791 :1133 , 2009
Abstract :
PubMedSearch : Ko_2009_Biochim.Biophys.Acta_1791_1133
PubMedID: 19651238
Gene_locus related to this paper: mouse-Ces1c

Title : Proteomic and lipid characterization of apolipoprotein B-free luminal lipid droplets from mouse liver microsomes: implications for very low density lipoprotein assembly - Wang_2007_J.Biol.Chem_282_33218
Author(s) : Wang H , Gilham D , Lehner R
Ref : Journal of Biological Chemistry , 282 :33218 , 2007
Abstract :
PubMedSearch : Wang_2007_J.Biol.Chem_282_33218
PubMedID: 17848546

Title : Attenuation of adipocyte triacylglycerol hydrolase activity decreases basal fatty acid efflux - Wei_2007_J.Biol.Chem_282_8027
Author(s) : Wei E , Gao W , Lehner R
Ref : Journal of Biological Chemistry , 282 :8027 , 2007
Abstract :
PubMedSearch : Wei_2007_J.Biol.Chem_282_8027
PubMedID: 17237500

Title : Mutation of F417 but not of L418 or L420 in the lipid binding domain decreases the activity of triacylglycerol hydrolase - Alam_2006_J.Lipid.Res_47_375
Author(s) : Alam M , Gilham D , Vance DE , Lehner R
Ref : J Lipid Res , 47 :375 , 2006
Abstract :
PubMedSearch : Alam_2006_J.Lipid.Res_47_375
PubMedID: 16282638
Gene_locus related to this paper: human-CES1

Title : Triacylglycerol hydrolase is localized to the endoplasmic reticulum by an unusual retrieval sequence where it participates in VLDL assembly without utilizing VLDL lipids as substrates - Gilham_2005_Mol.Biol.Cell_16_984
Author(s) : Gilham D , Alam M , Gao W , Vance DE , Lehner R
Ref : Mol Biology of the cell , 16 :984 , 2005
Abstract :
PubMedSearch : Gilham_2005_Mol.Biol.Cell_16_984
PubMedID: 15601899

Title : Insulin, glucagon and fatty acid treatment of hepatocytes does not result in phosphorylation or changes in activity of triacylglycerol hydrolase - Gilham_2005_Biochim.Biophys.Acta_1736_189
Author(s) : Gilham D , Perreault KR , Holmes CF , Brindley DN , Vance DE , Lehner R
Ref : Biochimica & Biophysica Acta , 1736 :189 , 2005
Abstract :
PubMedSearch : Gilham_2005_Biochim.Biophys.Acta_1736_189
PubMedID: 16168708

Title : C\/EBPalpha activates the transcription of triacylglycerol hydrolase in 3T3-L1 adipocytes - Wei_2005_Biochem.J_388_959
Author(s) : Wei E , Lehner R , Vance DE
Ref : Biochemical Journal , 388 :959 , 2005
Abstract :
PubMedSearch : Wei_2005_Biochem.J_388_959
PubMedID: 15752068

Title : Techniques to measure lipase and esterase activity in vitro - Gilham_2005_Methods_36_139
Author(s) : Gilham D , Lehner R
Ref : Methods , 36 :139 , 2005
Abstract :
PubMedSearch : Gilham_2005_Methods_36_139
PubMedID: 15893936

Title : Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone - Dolinsky_2004_Biochem.J_378_967
Author(s) : Dolinsky VW , Douglas DN , Lehner R , Vance DE
Ref : Biochemical Journal , 378 :967 , 2004
Abstract :
PubMedSearch : Dolinsky_2004_Biochem.J_378_967
PubMedID: 14662008

Title : The physiological role of triacylglycerol hydrolase in lipid metabolism -
Author(s) : Gilham D , Lehner R
Ref : Rev Endocr Metab Disord , 5 :303 , 2004
PubMedID: 15486462

Title : Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase - Soni_2004_J.Biol.Chem_279_40683
Author(s) : Soni KG , Lehner R , Metalnikov P , O'Donnell P , Semache M , Gao W , Ashman K , Pshezhetsky AV , Mitchell GA
Ref : Journal of Biological Chemistry , 279 :40683 , 2004
Abstract :
PubMedSearch : Soni_2004_J.Biol.Chem_279_40683
PubMedID: 15220344
Gene_locus related to this paper: mouse-Ces1d

Title : Triacylglycerol hydrolase: role in intracellular lipid metabolism - Dolinsky_2004_Cell.Mol.Life.Sci_61_1633
Author(s) : Dolinsky VW , Gilham D , Alam M , Vance DE , Lehner R
Ref : Cell Mol Life Sciences , 61 :1633 , 2004
Abstract :
PubMedSearch : Dolinsky_2004_Cell.Mol.Life.Sci_61_1633
PubMedID: 15224187
Gene_locus related to this paper: human-CES1

Title : Regulation of triacylglycerol hydrolase expression by dietary fatty acids and peroxisomal proliferator-activated receptors - Dolinsky_2003_Biochim.Biophys.Acta_1635_20
Author(s) : Dolinsky VW , Gilham D , Hatch GM , Agellon LB , Lehner R , Vance DE
Ref : Biochimica & Biophysica Acta , 1635 :20 , 2003
Abstract :
PubMedSearch : Dolinsky_2003_Biochim.Biophys.Acta_1635_20
PubMedID: 14642773

Title : Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion - Gilham_2003_FASEB.J_17_1685
Author(s) : Gilham D , Ho S , Rasouli M , Martres P , Vance DE , Lehner R
Ref : FASEB Journal , 17 :1685 , 2003
Abstract :
PubMedSearch : Gilham_2003_FASEB.J_17_1685
PubMedID: 12958176

Title : Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site - Alam_2002_Biochemistry_41_6679
Author(s) : Alam M , Vance DE , Lehner R
Ref : Biochemistry , 41 :6679 , 2002
Abstract :
PubMedSearch : Alam_2002_Biochemistry_41_6679
PubMedID: 12022871
Gene_locus related to this paper: human-CES1

Title : Heterologous expression, purification, and characterization of human triacylglycerol hydrolase - Alam_2002_Protein.Expr.Purif_24_33
Author(s) : Alam M , Ho S , Vance DE , Lehner R
Ref : Protein Expr Purif , 24 :33 , 2002
Abstract :
PubMedSearch : Alam_2002_Protein.Expr.Purif_24_33
PubMedID: 11812220
Gene_locus related to this paper: human-CES1

Title : A role for Sp1 in the transcriptional regulation of hepatic triacylglycerol hydrolase in the mouse - Douglas_2001_J.Biol.Chem_276_25621
Author(s) : Douglas DN , Dolinsky VW , Lehner R , Vance DE
Ref : Journal of Biological Chemistry , 276 :25621 , 2001
Abstract :
PubMedSearch : Douglas_2001_J.Biol.Chem_276_25621
PubMedID: 11337511

Title : The cloning and expression of a murine triacylglycerol hydrolase cDNA and the structure of its corresponding gene - Dolinsky_2001_Biochim.Biophys.Acta_1532_162
Author(s) : Dolinsky VW , Sipione S , Lehner R , Vance DE
Ref : Biochimica & Biophysica Acta , 1532 :162 , 2001
Abstract :
PubMedSearch : Dolinsky_2001_Biochim.Biophys.Acta_1532_162
PubMedID: 11470237
Gene_locus related to this paper: mouse-Ces1d

Title : Subcellullar localization, developmental expression and characterization of a liver triacylglycerol hydrolase - Lehner_1999_Biochem.J_338 ( Pt 3)_761
Author(s) : Lehner R , Cui Z , Vance DE
Ref : Biochemical Journal , 338 ( Pt 3) :761 , 1999
Abstract :
PubMedSearch : Lehner_1999_Biochem.J_338 ( Pt 3)_761
PubMedID: 10051450

Title : Cloning and expression of a cDNA encoding a hepatic microsomal lipase that mobilizes stored triacylglycerol - Lehner_1999_Biochem.J_343 Pt 1_1
Author(s) : Lehner R , Vance DE
Ref : Biochemical Journal , 343 Pt 1 :1 , 1999
Abstract :
PubMedSearch : Lehner_1999_Biochem.J_343 Pt 1_1
PubMedID: 10493905

Title : Purification and characterization of a porcine liver microsomal triacylglycerol hydrolase - Lehner_1997_Biochemistry_36_1861
Author(s) : Lehner R , Verger R
Ref : Biochemistry , 36 :1861 , 1997
Abstract :
PubMedSearch : Lehner_1997_Biochemistry_36_1861
PubMedID: 9048571

Title : Biosynthesis of triacylglycerols -
Author(s) : Lehner R , Kuksis A
Ref : Prog Lipid Res , 35 :169 , 1996
PubMedID: 8944226