| Title : Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd - Challacombe_2007_J.Bacteriol_189_1890 |
| Author(s) : Challacombe JF , Duncan AJ , Brettin TS , Bruce D , Chertkov O , Detter JC , Han CS , Misra M , Richardson P , Tapia R , Thayer N , Xie G , Inzana TJ |
| Ref : Journal of Bacteriology , 189 :1890 , 2007 |
| Abstract : Haemophilus somnus can be either a commensal of bovine mucosal surfaces or an opportunistic pathogen. Pathogenic strains of H. somnus are a significant cause of systemic disease in cattle. We report the genome sequence of H. somnus 129Pt, a nonpathogenic commensal preputial isolate, and the results of a genome-wide comparative analysis of H. somnus 129Pt, Haemophilus influenzae Rd, and Haemophilus ducreyi 35000HP. We found unique genes in H. somnus 129Pt involved in lipooligosaccharide biosynthesis, carbohydrate uptake and metabolism, cation transport, amino acid metabolism, ubiquinone and menaquinone biosynthesis, cell surface adhesion, biosynthesis of cofactors, energy metabolism, and electron transport. There were also many genes in common among the three organisms. Our comparative analyses of H. somnus 129Pt, H. influenzae Rd, and H. ducreyi 35000HP revealed similarities and differences in the numbers and compositions of genes involved in metabolism, host colonization, and persistence. These results lay a foundation for research on the host specificities and niche preferences of these organisms. Future comparisons between H. somnus 129Pt and virulent strains will aid in the development of protective strategies and vaccines to protect cattle against H. somnus disease. |
| ESTHER : Challacombe_2007_J.Bacteriol_189_1890 |
| PubMedSearch : Challacombe_2007_J.Bacteriol_189_1890 |
| PubMedID: 17172329 |
| Gene_locus related to this paper: haes1-q0i317 , haes1-q0i470 , haes2-b0utw7 , haes2-b0uvn0 , haes2-b0uwc2 |
| Gene_locus related to this paper: haes1-q0i317 , haes1-q0i470 , haes2-b0utw7 , haes2-b0uvn0 , haes2-b0uwc2 |
Challacombe JF, Duncan AJ, Brettin TS, Bruce D, Chertkov O, Detter JC, Han CS, Misra M, Richardson P, Tapia R, Thayer N, Xie G, Inzana TJ (2007)
Complete genome sequence of Haemophilus somnus (Histophilus somni) strain 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus influenzae Rd
Journal of Bacteriology
189 :1890
Challacombe JF, Duncan AJ, Brettin TS, Bruce D, Chertkov O, Detter JC, Han CS, Misra M, Richardson P, Tapia R, Thayer N, Xie G, Inzana TJ (2007)
Journal of Bacteriology
189 :1890