Pel_2007_Nat.Biotechnol_25_221

Reference

Title : Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88 - Pel_2007_Nat.Biotechnol_25_221
Author(s) : Pel HJ , de Winde JH , Archer DB , Dyer PS , Hofmann G , Schaap PJ , Turner G , de Vries RP , Albang R , Albermann K , Andersen MR , Bendtsen JD , Benen JA , van den Berg M , Breestraat S , Caddick MX , Contreras R , Cornell M , Coutinho PM , Danchin EG , Debets AJ , Dekker P , van Dijck PW , van Dijk A , Dijkhuizen L , Driessen AJ , d'Enfert C , Geysens S , Goosen C , Groot GS , de Groot PW , Guillemette T , Henrissat B , Herweijer M , van den Hombergh JP , van den Hondel CA , van der Heijden RT , van der Kaaij RM , Klis FM , Kools HJ , Kubicek CP , van Kuyk PA , Lauber J , Lu X , van der Maarel MJ , Meulenberg R , Menke H , Mortimer MA , Nielsen J , Oliver SG , Olsthoorn M , Pal K , van Peij NN , Ram AF , Rinas U , Roubos JA , Sagt CM , Schmoll M , Sun J , Ussery D , Varga J , Vervecken W , van de Vondervoort PJ , Wedler H , Wosten HA , Zeng AP , van Ooyen AJ , Visser J , Stam H
Ref : Nat Biotechnol , 25 :221 , 2007
Abstract :

The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabase genome of A. niger CBS 513.88, the ancestor of currently used enzyme production strains. A high level of synteny was observed with other aspergilli sequenced. Strong function predictions were made for 6,506 of the 14,165 open reading frames identified. A detailed description of the components of the protein secretion pathway was made and striking differences in the hydrolytic enzyme spectra of aspergilli were observed. A reconstructed metabolic network comprising 1,069 unique reactions illustrates the versatile metabolism of A. niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis.

PubMedSearch : Pel_2007_Nat.Biotechnol_25_221
PubMedID: 17259976
Gene_locus related to this paper: aspna-g3yal2 , aspnc-a2q8r7 , aspnc-a2q814 , aspnc-a2qb93 , aspnc-a2qbd3 , aspnc-a2qbh3 , aspnc-a2qbx7 , aspnc-a2qdj6 , aspnc-a2qe77 , aspnc-a2qf54 , aspnc-a2qfe9 , aspnc-a2qg33 , aspnc-a2qgj6 , aspnc-a2qgm6 , aspnc-a2qh52 , aspnc-a2qh76 , aspnc-a2qh85 , aspnc-a2qhe2 , aspnc-a2qi32 , aspnc-a2qib2 , aspnc-a2qk14 , aspnc-a2ql23 , aspnc-a2ql89 , aspnc-a2ql90 , aspnc-a2qla0 , aspnc-a2qlz0 , aspnc-a2qm14 , aspnc-a2qmk5 , aspnc-a2qms0 , aspnc-a2qn29 , aspnc-a2qn56 , aspnc-a2qn70 , aspnc-a2qnw9 , aspnc-a2qr21 , aspnc-a2qs22 , aspnc-a2qt50 , aspnc-a2qti9 , aspnc-a2qtz0 , aspnc-a2quc1 , aspnc-a2qw06 , aspnc-a2qwz6 , aspnc-a2qx92 , aspnc-a2qyf0 , aspnc-a2qys7 , aspnc-a2qz72 , aspnc-a2qzn6 , aspnc-a2qzr0 , aspnc-a2qzs1 , aspnc-a2qzx0 , aspnc-a2qzx4 , aspnc-a2r0p4 , aspnc-a2r0u0 , aspnc-a2r1p3 , aspnc-a2r1r5 , aspnc-a2r2i5 , aspnc-a2r2l0 , aspnc-a2r3s8 , aspnc-a2r4c0 , aspnc-a2r4j8 , aspnc-a2r5r4 , aspnc-a2r6g3 , aspnc-a2r6h5 , aspnc-a2r6h8 , aspnc-a2r7q1 , aspnc-a2r8r3 , aspnc-a2r8z3 , aspnc-a2r9y8 , aspnc-a2r032 , aspnc-a2r040 , aspnc-a2r273 , aspnc-a2r496 , aspnc-a2r502 , aspnc-a2ra07 , aspnc-a2rap4 , aspnc-a2raq2 , aspnc-a2rav1 , aspnc-a5aaf4 , aspnc-a5ab63 , aspnc-a5abc6 , aspnc-a5abe5 , aspnc-a5abe8 , aspnc-a5abf0 , aspnc-a5abh9 , aspnc-a5abk1 , aspnc-a5abt2 , aspnc-a5abz1 , aspnc-atg15 , aspnc-axe1 , aspnc-cuti1 , aspnc-cuti2 , aspnc-faec , aspng-a2q8w0 , aspng-a2qs46 , aspng-a2qst4 , aspng-a2qv27 , aspng-a2qzk9 , aspng-a2r0p8 , aspng-a2r225 , aspng-DAPB , aspng-DPP5 , aspng-faeb , aspni-APSC , aspni-EstA , aspni-FAEA , aspni-PAPA , aspkw-g7y0v7 , aspnc-a2qt47 , aspnc-a2qt66 , aspnc-a2r199 , aspnc-a2r871 , aspnc-a2qbp6 , aspnc-a2qqa1 , aspnc-a2qt70 , aspna-g3y5a6 , aspna-g3xpw9 , aspnc-a2qw57 , aspaw-a0a401kcz4 , aspna-alba , aspnc-kex1 , aspnc-cbpya , aspnc-a2qbg8

Related information

Gene_locus aspna-g3yal2    aspnc-a2q8r7    aspnc-a2q814    aspnc-a2qb93    aspnc-a2qbd3    aspnc-a2qbh3    aspnc-a2qbx7    aspnc-a2qdj6    aspnc-a2qe77    aspnc-a2qf54    aspnc-a2qfe9    aspnc-a2qg33    aspnc-a2qgj6    aspnc-a2qgm6    aspnc-a2qh52    aspnc-a2qh76    aspnc-a2qh85    aspnc-a2qhe2    aspnc-a2qi32    aspnc-a2qib2    aspnc-a2qk14    aspnc-a2ql23    aspnc-a2ql89    aspnc-a2ql90    aspnc-a2qla0    aspnc-a2qlz0    aspnc-a2qm14    aspnc-a2qmk5    aspnc-a2qms0    aspnc-a2qn29    aspnc-a2qn56    aspnc-a2qn70    aspnc-a2qnw9    aspnc-a2qr21    aspnc-a2qs22    aspnc-a2qt50    aspnc-a2qti9    aspnc-a2qtz0    aspnc-a2quc1    aspnc-a2qw06    aspnc-a2qwz6    aspnc-a2qx92    aspnc-a2qyf0    aspnc-a2qys7    aspnc-a2qz72    aspnc-a2qzn6    aspnc-a2qzr0    aspnc-a2qzs1    aspnc-a2qzx0    aspnc-a2qzx4    aspnc-a2r0p4    aspnc-a2r0u0    aspnc-a2r1p3    aspnc-a2r1r5    aspnc-a2r2i5    aspnc-a2r2l0    aspnc-a2r3s8    aspnc-a2r4c0    aspnc-a2r4j8    aspnc-a2r5r4    aspnc-a2r6g3    aspnc-a2r6h5    aspnc-a2r6h8    aspnc-a2r7q1    aspnc-a2r8r3    aspnc-a2r8z3    aspnc-a2r9y8    aspnc-a2r032    aspnc-a2r040    aspnc-a2r273    aspnc-a2r496    aspnc-a2r502    aspnc-a2ra07    aspnc-a2rap4    aspnc-a2raq2    aspnc-a2rav1    aspnc-a5aaf4    aspnc-a5ab63    aspnc-a5abc6    aspnc-a5abe5    aspnc-a5abe8    aspnc-a5abf0    aspnc-a5abh9    aspnc-a5abk1    aspnc-a5abt2    aspnc-a5abz1    aspnc-atg15    aspnc-axe1    aspnc-cuti1    aspnc-cuti2    aspnc-faec    aspng-a2q8w0    aspng-a2qs46    aspng-a2qst4    aspng-a2qv27    aspng-a2qzk9    aspng-a2r0p8    aspng-a2r225    aspng-DAPB    aspng-DPP5    aspng-faeb    aspni-APSC    aspni-EstA    aspni-FAEA    aspni-PAPA    aspkw-g7y0v7    aspnc-a2qt47    aspnc-a2qt66    aspnc-a2r199    aspnc-a2r871    aspnc-a2qbp6    aspnc-a2qqa1    aspnc-a2qt70    aspna-g3y5a6    aspna-g3xpw9    aspnc-a2qw57    aspaw-a0a401kcz4    aspna-alba    aspnc-kex1    aspnc-cbpya    aspnc-a2qbg8
Gene_locus_frgt aspna-G3Y7U8    aspnc-a2qky7

Citations formats

Pel HJ, de Winde JH, Archer DB, Dyer PS, Hofmann G, Schaap PJ, Turner G, de Vries RP, Albang R, Albermann K, Andersen MR, Bendtsen JD, Benen JA, van den Berg M, Breestraat S, Caddick MX, Contreras R, Cornell M, Coutinho PM, Danchin EG, Debets AJ, Dekker P, van Dijck PW, van Dijk A, Dijkhuizen L, Driessen AJ, d'Enfert C, Geysens S, Goosen C, Groot GS, de Groot PW, Guillemette T, Henrissat B, Herweijer M, van den Hombergh JP, van den Hondel CA, van der Heijden RT, van der Kaaij RM, Klis FM, Kools HJ, Kubicek CP, van Kuyk PA, Lauber J, Lu X, van der Maarel MJ, Meulenberg R, Menke H, Mortimer MA, Nielsen J, Oliver SG, Olsthoorn M, Pal K, van Peij NN, Ram AF, Rinas U, Roubos JA, Sagt CM, Schmoll M, Sun J, Ussery D, Varga J, Vervecken W, van de Vondervoort PJ, Wedler H, Wosten HA, Zeng AP, van Ooyen AJ, Visser J, Stam H (2007)
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
Nat Biotechnol 25 :221

Pel HJ, de Winde JH, Archer DB, Dyer PS, Hofmann G, Schaap PJ, Turner G, de Vries RP, Albang R, Albermann K, Andersen MR, Bendtsen JD, Benen JA, van den Berg M, Breestraat S, Caddick MX, Contreras R, Cornell M, Coutinho PM, Danchin EG, Debets AJ, Dekker P, van Dijck PW, van Dijk A, Dijkhuizen L, Driessen AJ, d'Enfert C, Geysens S, Goosen C, Groot GS, de Groot PW, Guillemette T, Henrissat B, Herweijer M, van den Hombergh JP, van den Hondel CA, van der Heijden RT, van der Kaaij RM, Klis FM, Kools HJ, Kubicek CP, van Kuyk PA, Lauber J, Lu X, van der Maarel MJ, Meulenberg R, Menke H, Mortimer MA, Nielsen J, Oliver SG, Olsthoorn M, Pal K, van Peij NN, Ram AF, Rinas U, Roubos JA, Sagt CM, Schmoll M, Sun J, Ussery D, Varga J, Vervecken W, van de Vondervoort PJ, Wedler H, Wosten HA, Zeng AP, van Ooyen AJ, Visser J, Stam H (2007)
Nat Biotechnol 25 :221