| Title : Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit - Willis_2022_J.Med.Chem_65_7212 |
| Author(s) : Willis NJ , Mahy W , Sipthorp J , Zhao Y , Woodward HL , Atkinson BN , Bayle ED , Svensson F , Frew S , Jeganathan F , Monaghan A , Benvegnu S , Jolly S , Vecchia L , Ruza RR , Kjaer S , Howell SA , Snidjers AP , Bictash M , Salinas PC , Vincent JP , Jones EY , Whiting P , Fish PV |
| Ref : Journal of Medicinal Chemistry , 65 :7212 , 2022 |
| Abstract : Willis_2022_J.Med.Chem_65_7212 |
| ESTHER : Willis_2022_J.Med.Chem_65_7212 |
| PubMedSearch : Willis_2022_J.Med.Chem_65_7212 |
| PubMedID: 35536179 |
| Gene_locus related to this paper: human-NOTUM |
| Gene_locus related to this paper: human-NOTUM |
Willis NJ, Mahy W, Sipthorp J, Zhao Y, Woodward HL, Atkinson BN, Bayle ED, Svensson F, Frew S, Jeganathan F, Monaghan A, Benvegnu S, Jolly S, Vecchia L, Ruza RR, Kjaer S, Howell SA, Snidjers AP, Bictash M, Salinas PC, Vincent JP, Jones EY, Whiting P, Fish PV (2022)
Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit
Journal of Medicinal Chemistry
65 :7212
Willis NJ, Mahy W, Sipthorp J, Zhao Y, Woodward HL, Atkinson BN, Bayle ED, Svensson F, Frew S, Jeganathan F, Monaghan A, Benvegnu S, Jolly S, Vecchia L, Ruza RR, Kjaer S, Howell SA, Snidjers AP, Bictash M, Salinas PC, Vincent JP, Jones EY, Whiting P, Fish PV (2022)
Journal of Medicinal Chemistry
65 :7212