K298
General
Type : Quinoline, Bispyridinium
Chemical_Nomenclature : 1-(8-quinolin-1-ium-1-yloctyl)quinolin-1-ium
Canonical SMILES : C1=CC=C2C(=C1)C=CC=[N+]2CCCCCCCC[N+]3=CC=CC4=CC=CC=C43
InChI : InChI=1S\/C26H30N2\/c1(3-9-19-27-21-11-15-23-13-5-7-17-25(23)27)2-4-10-20-28-22-12-16-24-14-6-8-18-26(24)28\/h5-8,11-18,21-22H,1-4,9-10,19-20H2\/q+2
InChIKey : LGGRUTTWKKNPBL-UHFFFAOYSA-N
Other name(s) : CHEMBL276745 || SCHEMBL3604422 || CHEMBL1183036 || BDBM50119787 || 1,1'-(Octane-1,8-diyl)diquinolinium || CHEMBL1761995
MW : 530.34
Formula : C26H30Br2N2
CAS_number :
PubChem : 54581375
UniChem : LGGRUTTWKKNPBL-UHFFFAOYSA-N
Target
Structure : No structure
Families : No family
References (3)
| Title : Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings - Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| Author(s) : Kuca K , Karasova JZ , Soukup O , Kassa J , Novotna E , Sepsova V , Horova A , Pejchal J , Hrabinova M , Vodakova E , Jun D , Nepovimova E , Valis M , Musilek K |
| Ref : Drug Des Devel Ther , 12 :505 , 2018 |
| Abstract : |
| PubMedSearch : Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| PubMedID: 29563775 |
| Title : A comparison of the efficacy of newly developed reversible inhibitors of acetylcholinesterase with commonly used pyridostigmine as pharmacological pre-treatment of soman-poisoned mice - Kassa_2012_Basic.Clin.Pharmacol.Toxicol_110_322 |
| Author(s) : Kassa J , Musilek K , Koomlova M , Bajgar J |
| Ref : Basic Clin Pharmacol Toxicol , 110 :322 , 2012 |
| Abstract : |
| PubMedSearch : Kassa_2012_Basic.Clin.Pharmacol.Toxicol_110_322 |
| PubMedID: 21981462 |
| Title : Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment - Komloova_2011_Bioorg.Med.Chem.Lett_21_2505 |
| Author(s) : Komloova M , Musilek K , Horova A , Holas O , Dohnal V , Gunn-Moore F , Kuca K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2505 , 2011 |
| Abstract : |
| PubMedSearch : Komloova_2011_Bioorg.Med.Chem.Lett_21_2505 |
| PubMedID: 21397501 |