Full name : Kosak Urban
First name : Urban
Mail : Faculty of Pharmacy, University of Ljubljana
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Country : Slovenia
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Comment
| Title : Dual inhibition of butyrylcholinesterase and p38alpha mitogen-activated protein kinase: A new approach for the treatment of Alzheimer's disease - Benetik_2024_Pharmacol.Ther__108748 |
| Author(s) : Benetik SF , Knez D , Obreza A , Kosak U , Gobec S |
| Ref : Pharmacol Ther , :108748 , 2024 |
| Abstract : |
| PubMedSearch : Benetik_2024_Pharmacol.Ther__108748 |
| PubMedID: 39521443 |
| Title : Repurposing of 8-Hydroxyquinoline-based Butyrylcholinesterase and Cathepsin B Ligands as Potent Non-peptidic Deoxyribonuclease I Inhibitors - Gajic_2022_ChemMedChem__ |
| Author(s) : Gajic M , Knez D , Sosic I , Mravljak J , Meden A , Kosak U , Leitzbach L , George S , Hofmann B , Zivkovic A , Steinhilber D , Stark H , Gobec S , Smelcerovic A , Anderluh M |
| Ref : ChemMedChem , : , 2022 |
| Abstract : |
| PubMedSearch : Gajic_2022_ChemMedChem__ |
| PubMedID: 34994078 |
| Title : Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease - Rejc_2021_Theranostics_11_6542 |
| Author(s) : Rejc L , Gomez-Vallejo V , Joya A , Moreno O , Egimendia A , Castellnou P , Rios-Anglada X , Cossio U , Baz Z , Passannante R , Tobalina-Larrea I , Ramos-Cabrer P , Giralt A , Sastre M , Capetillo-Zarate E , Kosak U , Knez D , Gobec S , Marder M , Martin A , Llop J |
| Ref : Theranostics , 11 :6542 , 2021 |
| Abstract : |
| PubMedSearch : Rejc_2021_Theranostics_11_6542 |
| PubMedID: 33995675 |
| Title : Synthesis and Initial Characterization of a Reversible, Selective (18)F-Labeled Radiotracer for Human Butyrylcholinesterase - Gentzsch_2021_Mol.Imaging.Biol__ |
| Author(s) : Gentzsch C , Chen X , Spatz P , Kosak U , Knez D , Nose N , Gobec S , Higuchi T , Decker M |
| Ref : Mol Imaging Biol , : , 2021 |
| Abstract : |
| PubMedSearch : Gentzsch_2021_Mol.Imaging.Biol__ |
| PubMedID: 33660167 |
| Title : Treatment of canine cognitive dysfunction with novel butyrylcholinesterase inhibitor - Zakosek Pipan_2021_Sci.Rep_11_18098 |
| Author(s) : Zakosek Pipan M , Prpar Mihevc S , Strbenc M , Kosak U , German Ilic I , Trontelj J , Zakelj S , Gobec S , Pavlin D , Majdic G |
| Ref : Sci Rep , 11 :18098 , 2021 |
| Abstract : |
| PubMedSearch : Zakosek Pipan_2021_Sci.Rep_11_18098 |
| PubMedID: 34518582 |
| Title : N-alkylpiperidine carbamates as potential anti-Alzheimer's agents - Kosak_2020_Eur.J.Med.Chem_197_112282 |
| Author(s) : Kosak U , Strasek N , Knez N , Jukic M , Zakelj S , Zahirovic A , Pislar A , Brazzolotto X , Nachon F , Kos J , Gobec S , Knez D |
| Ref : Eur Journal of Medicinal Chemistry , 197 :112282 , 2020 |
| Abstract : |
| PubMedSearch : Kosak_2020_Eur.J.Med.Chem_197_112282 |
| PubMedID: 32380361 |
| Gene_locus related to this paper: human-BCHE |
| Title : Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes - Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498 |
| Author(s) : Pajk S , Knez D , Kosak U , Zorovic M , Brazzolotto X , Coquelle N , Nachon F , Colletier JP , Zivin M , Stojan J , Gobec S |
| Ref : J Enzyme Inhib Med Chem , 35 :498 , 2020 |
| Abstract : |
| PubMedSearch : Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498 |
| PubMedID: 31914836 |
| Gene_locus related to this paper: human-BCHE |
| Title : The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity - Kosak_2018_J.Med.Chem_61_119 |
| Author(s) : Kosak U , Brus B , Knez D , Zakelj S , Trontelj J , Pislar A , Sink R , Jukic M , Zivin M , Podkowa A , Nachon F , Brazzolotto X , Stojan J , Kos J , Coquelle N , Salat K , Colletier JP , Gobec S |
| Ref : Journal of Medicinal Chemistry , 61 :119 , 2018 |
| Abstract : |
| PubMedSearch : Kosak_2018_J.Med.Chem_61_119 |
| PubMedID: 29227101 |
| Gene_locus related to this paper: human-BCHE |
| Title : N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents - Kosak_2017_Bioorg.Med.Chem_25_633 |
| Author(s) : Kosak U , Knez D , Coquelle N , Brus B , Pislar A , Nachon F , Brazzolotto X , Kos J , Colletier JP , Gobec S |
| Ref : Bioorganic & Medicinal Chemistry , 25 :633 , 2017 |
| Abstract : |
| PubMedSearch : Kosak_2017_Bioorg.Med.Chem_25_633 |
| PubMedID: 27908752 |
| Gene_locus related to this paper: human-BCHE |
| Title : Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer's disease - Knez_2017_Future.Med.Chem_9_811 |
| Author(s) : Knez D , Sova M , Kosak U , Gobec S |
| Ref : Future Med Chem , 9 :811 , 2017 |
| Abstract : |
| PubMedSearch : Knez_2017_Future.Med.Chem_9_811 |
| PubMedID: 28504893 |
| Title : Development of an in-vivo active reversible butyrylcholinesterase inhibitor - Kosak_2016_Sci.Rep_6_39495 |
| Author(s) : Kosak U , Brus B , Knez D , Sink R , Zakelj S , Trontelj J , Pislar A , Slenc J , Gobec M , Zivin M , Tratnjek L , Perse M , Salat K , Podkowa A , Filipek B , Nachon F , Brazzolotto X , Wieckowska A , Malawska B , Stojan J , Rascan IM , Kos J , Coquelle N , Colletier JP , Gobec S |
| Ref : Sci Rep , 6 :39495 , 2016 |
| Abstract : |
| PubMedSearch : Kosak_2016_Sci.Rep_6_39495 |
| PubMedID: 28000737 |
| Gene_locus related to this paper: human-BCHE |
| Title : Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor - Brus_2014_J.Med.Chem_57_8167 |
| Author(s) : Brus B , Kosak U , Turk S , Pislar A , Coquelle N , Kos J , Stojan J , Colletier JP , Gobec S |
| Ref : Journal of Medicinal Chemistry , 57 :8167 , 2014 |
| Abstract : |
| PubMedSearch : Brus_2014_J.Med.Chem_57_8167 |
| PubMedID: 25226236 |
| Gene_locus related to this paper: human-BCHE |