9I02
Name : Human butyrylcholinesterase in complex with N-((1-Benzylpyrrolidin-3-yl)methyl)-N-methylnaphthalene-2-sulfonamide (S)-(+)-3
Revelation date : 02-Jul-2025
Family : BCHE
Gene_locus : human-BCHE
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Ligand : Inhibitor Benzylpyrrolidin-methyl-N-methylnaphthalene-2-sulfonamide-(S)-(+)-3 Ligand in structure: Ligplot
References (1)
| Title : Lead Optimization of a Butyrylcholinesterase Inhibitor for the Treatment of Alzheimer's Disease - Kosak_2025_J.Med.Chem__ |
| Author(s) : Kosak U , Strasek Benedik N , Knez D , Zakelj S , Trontelj J , Pislar A , Horvat S , Bolje A , Znidarsic N , Grgurevic N , Svara T , Kljun J , Skrzypczak-Wiercioch A , Lv B , Xiong Y , Wang Q , Bian R , Shao J , Dias J , Nachon F , Brazzolotto X , Stojan J , Sun H , Salat K , Gobec S |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_J.Med.Chem__ |
| PubMedID: 40454648 |
| Gene_locus related to this paper: human-BCHE |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 9I02 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 9I02 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 9I02 Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 9I02 3D, interactive encyclopedia of proteins - PROTEOPEDIA server