| Title : Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38alpha Mitogen-Activated Protein Kinase Inhibitors - Ferjancic Benetik_2025_J.Med.Chem__ |
| Author(s) : Ferjancic Benetik S , Proj M , Knez D , Kosak U , Meden A , Krajsek K , Pislar A , Horvat S , Svajger U , Tesic N , Pulkrabkova L , Soukup O , Skarka A , Andrys R , Brazzolotto X , Igert A , Nachon F , Dias J , Detka J , Gdula-Argasinska J , Wyska E , Szafarz M , Manik A , Plachtij N , Musilek K , Salat K , Obreza A , Gobec S |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Ferjancic Benetik_2025_J.Med.Chem__ |
| PubMedID: 40779804 |
| Title : Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38alpha Mitogen-Activated Protein Kinase Inhibitors - Ferjancic Benetik_2025_J.Med.Chem__ |
| Author(s) : Ferjancic Benetik S , Proj M , Knez D , Kosak U , Meden A , Krajsek K , Pislar A , Horvat S , Svajger U , Tesic N , Pulkrabkova L , Soukup O , Skarka A , Andrys R , Brazzolotto X , Igert A , Nachon F , Dias J , Detka J , Gdula-Argasinska J , Wyska E , Szafarz M , Manik A , Plachtij N , Musilek K , Salat K , Obreza A , Gobec S |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Ferjancic Benetik_2025_J.Med.Chem__ |
| PubMedID: 40779804 |
| Title : Lead Optimization of a Butyrylcholinesterase Inhibitor for the Treatment of Alzheimer's Disease - Kosak_2025_J.Med.Chem__ |
| Author(s) : Kosak U , Strasek Benedik N , Knez D , Zakelj S , Trontelj J , Pislar A , Horvat S , Bolje A , Znidarsic N , Grgurevic N , Svara T , Kljun J , Skrzypczak-Wiercioch A , Lv B , Xiong Y , Wang Q , Bian R , Shao J , Dias J , Nachon F , Brazzolotto X , Stojan J , Sun H , Salat K , Gobec S |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_J.Med.Chem__ |
| PubMedID: 40454648 |
| Gene_locus related to this paper: human-BCHE |
| Title : Lead Optimization of a Butyrylcholinesterase Inhibitor for the Treatment of Alzheimer's Disease - Kosak_2025_J.Med.Chem__ |
| Author(s) : Kosak U , Strasek Benedik N , Knez D , Zakelj S , Trontelj J , Pislar A , Horvat S , Bolje A , Znidarsic N , Grgurevic N , Svara T , Kljun J , Skrzypczak-Wiercioch A , Lv B , Xiong Y , Wang Q , Bian R , Shao J , Dias J , Nachon F , Brazzolotto X , Stojan J , Sun H , Salat K , Gobec S |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_J.Med.Chem__ |
| PubMedID: 40454648 |
| Gene_locus related to this paper: human-BCHE |
| Title : N-Propargylpyrrolidine-based butyrylcholinesterase and monoamine oxidase inhibitors - Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111681 |
| Author(s) : Kosak U , Knez D , Pislar A , Horvat S , Zakelj S , Igert A , Dias J , Nachon F , Brazzolotto X , Gobec S |
| Ref : Chemico-Biological Interactions , 420 :111681 , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111681 |
| PubMedID: 40750068 |
| Gene_locus related to this paper: human-BCHE |
| Title : Chiral switch of a butyrylcholinesterase inhibitor for the treatment of Alzheimer's disease - Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111670 |
| Author(s) : Kosak U , Knez D , Benetik SF , Sokolov PM , Pislar A , Horvat S , Stojan J , Lv B , Zhang W , Wang Y , Wang Q , Igert A , Dias J , Nachon F , Brazzolotto X , Sun H , Gobec S |
| Ref : Chemico-Biological Interactions , 420 :111670 , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111670 |
| PubMedID: 40712769 |
| Gene_locus related to this paper: human-BCHE |
| Title : N-Propargylpyrrolidine-based butyrylcholinesterase and monoamine oxidase inhibitors - Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111681 |
| Author(s) : Kosak U , Knez D , Pislar A , Horvat S , Zakelj S , Igert A , Dias J , Nachon F , Brazzolotto X , Gobec S |
| Ref : Chemico-Biological Interactions , 420 :111681 , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111681 |
| PubMedID: 40750068 |
| Gene_locus related to this paper: human-BCHE |
| Title : Transforming ureas into carbamates: From allosteric p38alpha MAPK ligands to dual BChE\/p38alpha MAPK inhibitors - Ferjancic Benetik_2025_Bioorg.Chem_165_108998 |
| Author(s) : Benetik SF , Meden A , Knez D , Mastnak-Sokolov P , Kosak U , Horvat S , Pislar A , Andrys R , Musilek K , Detka J , Salat K , Obreza A , Gobec S |
| Ref : Bioorg Chem , 165 :108998 , 2025 |
| Abstract : |
| PubMedSearch : Ferjancic Benetik_2025_Bioorg.Chem_165_108998 |
| PubMedID: 40987175 |
| Gene_locus related to this paper: human-BCHE |
| Title : Chiral switch of a butyrylcholinesterase inhibitor for the treatment of Alzheimer's disease - Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111670 |
| Author(s) : Kosak U , Knez D , Benetik SF , Sokolov PM , Pislar A , Horvat S , Stojan J , Lv B , Zhang W , Wang Y , Wang Q , Igert A , Dias J , Nachon F , Brazzolotto X , Sun H , Gobec S |
| Ref : Chemico-Biological Interactions , 420 :111670 , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111670 |
| PubMedID: 40712769 |
| Gene_locus related to this paper: human-BCHE |
| Title : Transforming ureas into carbamates: From allosteric p38alpha MAPK ligands to dual BChE\/p38alpha MAPK inhibitors - Ferjancic Benetik_2025_Bioorg.Chem_165_108998 |
| Author(s) : Benetik SF , Meden A , Knez D , Mastnak-Sokolov P , Kosak U , Horvat S , Pislar A , Andrys R , Musilek K , Detka J , Salat K , Obreza A , Gobec S |
| Ref : Bioorg Chem , 165 :108998 , 2025 |
| Abstract : |
| PubMedSearch : Ferjancic Benetik_2025_Bioorg.Chem_165_108998 |
| PubMedID: 40987175 |
| Gene_locus related to this paper: human-BCHE |
| Title : Lead Optimization of a Butyrylcholinesterase Inhibitor for the Treatment of Alzheimer's Disease - Kosak_2025_J.Med.Chem__ |
| Author(s) : Kosak U , Strasek Benedik N , Knez D , Zakelj S , Trontelj J , Pislar A , Horvat S , Bolje A , Znidarsic N , Grgurevic N , Svara T , Kljun J , Skrzypczak-Wiercioch A , Lv B , Xiong Y , Wang Q , Bian R , Shao J , Dias J , Nachon F , Brazzolotto X , Stojan J , Sun H , Salat K , Gobec S |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_J.Med.Chem__ |
| PubMedID: 40454648 |
| Gene_locus related to this paper: human-BCHE |
| Title : N-Propargylpyrrolidine-based butyrylcholinesterase and monoamine oxidase inhibitors - Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111681 |
| Author(s) : Kosak U , Knez D , Pislar A , Horvat S , Zakelj S , Igert A , Dias J , Nachon F , Brazzolotto X , Gobec S |
| Ref : Chemico-Biological Interactions , 420 :111681 , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111681 |
| PubMedID: 40750068 |
| Gene_locus related to this paper: human-BCHE |
| Title : Chiral switch of a butyrylcholinesterase inhibitor for the treatment of Alzheimer's disease - Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111670 |
| Author(s) : Kosak U , Knez D , Benetik SF , Sokolov PM , Pislar A , Horvat S , Stojan J , Lv B , Zhang W , Wang Y , Wang Q , Igert A , Dias J , Nachon F , Brazzolotto X , Sun H , Gobec S |
| Ref : Chemico-Biological Interactions , 420 :111670 , 2025 |
| Abstract : |
| PubMedSearch : Kosak_2025_Chem.Biol.Interact_15ChEPon_420_111670 |
| PubMedID: 40712769 |
| Gene_locus related to this paper: human-BCHE |
| Title : Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38alpha Mitogen-Activated Protein Kinase Inhibitors - Ferjancic Benetik_2025_J.Med.Chem__ |
| Author(s) : Ferjancic Benetik S , Proj M , Knez D , Kosak U , Meden A , Krajsek K , Pislar A , Horvat S , Svajger U , Tesic N , Pulkrabkova L , Soukup O , Skarka A , Andrys R , Brazzolotto X , Igert A , Nachon F , Dias J , Detka J , Gdula-Argasinska J , Wyska E , Szafarz M , Manik A , Plachtij N , Musilek K , Salat K , Obreza A , Gobec S |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Ferjancic Benetik_2025_J.Med.Chem__ |
| PubMedID: 40779804 |
| Title : Transforming ureas into carbamates: From allosteric p38alpha MAPK ligands to dual BChE\/p38alpha MAPK inhibitors - Ferjancic Benetik_2025_Bioorg.Chem_165_108998 |
| Author(s) : Benetik SF , Meden A , Knez D , Mastnak-Sokolov P , Kosak U , Horvat S , Pislar A , Andrys R , Musilek K , Detka J , Salat K , Obreza A , Gobec S |
| Ref : Bioorg Chem , 165 :108998 , 2025 |
| Abstract : |
| PubMedSearch : Ferjancic Benetik_2025_Bioorg.Chem_165_108998 |
| PubMedID: 40987175 |
| Gene_locus related to this paper: human-BCHE |