Fosinopril
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II. Babesia BdFE1 esterase is required for the anti-parasitic activity of the ACE inhibitor fosinopril
General
Type : Not AlphaBeta Hydrolase target, Drug, Pro-Drug, Pyrrolidine, Angiotensin-converting enzyme inhibitor, Organophosphate
Chemical_Nomenclature : (2S,4S)-4-cyclohexyl-1-[2-[[(1S)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid
Canonical SMILES : CCC(=O)OC(C(C)C)OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N2CC(CC2C(=O)O)C3CCCCC3
InChI : InChI=1S\/C30H46NO7P\/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24\/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35)\/t25-,26+,30+,39-\/m1\/s1
InChIKey : BIDNLKIUORFRQP-XYGFDPSESA-N
Other name(s) : Fozitec || Fosenopril || C09AA09 || SQ-28555 || DB00492
MW : 563.7
Formula : C30H46NO7P
CAS_number : 98048-97-6
PubChem : 9601226
UniChem : BIDNLKIUORFRQP-XYGFDPSESA-N
Target
Structures : No structure
Families : Plasmodium_subtelomeric_PST-A, Carb_B_Chordata
References (4)
| Title : Babesia BdFE1 Esterase is Required for the Anti-parasitic Activity of the ACE Inhibitor Fosinopril - Vydyam_2023_J.Biol.Chem__105313 |
| Author(s) : Vydyam P , Choi JY , Gihaz S , Chand M , Gewirtz M , Thekkiniath J , Lonardi S , Gennaro JC , Ben Mamoun C |
| Ref : Journal of Biological Chemistry , :105313 , 2023 |
| Abstract : |
| PubMedSearch : Vydyam_2023_J.Biol.Chem__105313 |
| PubMedID: 37797695 |
| Gene_locus related to this paper: 9apic-BdFE1 |
| Title : CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors - Wang_2016_Pharmacogenomics.J_16_220 |
| Author(s) : Wang X , Wang G , Shi J , Aa JY , Comas R , Liang Y , Zhu HJ |
| Ref : Pharmacogenomics J , 16 :220 , 2016 |
| Abstract : |
| PubMedSearch : Wang_2016_Pharmacogenomics.J_16_220 |
| PubMedID: 26076923 |
| Gene_locus related to this paper: human-CES1 |
| Title : Oculohypotensive effect of angiotensin-converting enzyme inhibitors in acute and chronic models of glaucoma - Shah_2000_J.Cardiovasc.Pharmacol_36_169 |
| Author(s) : Shah GB , Sharma S , Mehta AA , Goyal RK |
| Ref : J Cardiovasc Pharmacol , 36 :169 , 2000 |
| Abstract : |
| PubMedSearch : Shah_2000_J.Cardiovasc.Pharmacol_36_169 |
| PubMedID: 10942157 |
| Title : Fosinopril treatment of pregnant rats: developmental toxicity, fetal angiotensin-converting enzyme inhibition, and fetal angiotensin II receptor regulation - Grove_1995_Toxicol.Lett_80_85 |
| Author(s) : Grove KL , Mayo RJ , Forsyth CS , Frank AA , Speth RC |
| Ref : Toxicology Letters , 80 :85 , 1995 |
| Abstract : |
| PubMedSearch : Grove_1995_Toxicol.Lett_80_85 |
| PubMedID: 7482596 |