Derivative of Neostigmine~Prostigmine

Neostigmine~Prostigmine cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE- ESERINE, does not cross the blood-brain barrier. Parasympathomimetic as well as Neostigmine Methyl Sulfate. Used to reverse action of neuromuscular blockers and snake venoms. There is also Nor-physostigmine(...-dimethyl aminoformate).Neostigmine sulfoxymethane (Juvastigmin,Kirkstigmine, Neostigmeth, Normastigmin, Polstigmine, Synstigmine, Syntostigmin, Hodostin, Proserin Hoffman-La-Roche prostigmine was marketed in the early 1930s for the treatment of glaucoma, myasthenia gravis, to increase gut and bladder functions.