serine protease inhibitor
Type : Sulfur Compound,Sulfonyl
Chemical_Nomenclature : 4-(2-aminoethyl)benzenesulfonyl fluoride
Canonical SMILES : C1=CC(=CC=C1CCN)S(=O)(=O)F
InChI : InChI=1S\/C8H10FNO2S\/c9-13(11,12)8-3-1-7(2-4-8)5-6-10\/h1-4H,5-6,10H2
InChIKey : MGSKVZWGBWPBTF-UHFFFAOYSA-N
Other name(s) : 4-(2-Aminoethyl)benzenesulfonyl fluoride,Pefabloc,4-(2-Aminoethyl)benzenesulfonylfluoride,Benzenesulfonyl fluoride, 4-(2-aminoethyl)-
MW : 203.23
Formula : C8H10FNO2S
CAS_number : 34284-75-8
PubChem : 1701
UniChem : MGSKVZWGBWPBTF-UHFFFAOYSA-N
Families : AEBSF ligand of proteins in family
S9N_PREPL_Peptidase_S9
5_AlphaBeta_hydrolase
DPP4N_Peptidase_S9
Tiancimycin-TnmK-Tripeptidase-HIP
Protein :
pig-dpp4
leima-OPB
halo1-d0lmj0
human-FAP
myctu-ym24
Title : 2.1 A crystal structure of the Mycobacterium tuberculosis serine hydrolase, Hip1, in its anhydro-form (Anhydrohip1) - Brooks_2022_Biochem.Biophys.Res.Commun_630_57 |
Author(s) : Brooks CL , Ostrov DA , Schumann NC , Kakkad S , Li D , Pena K , Williams BP , Goldfarb NE |
Ref : Biochemical & Biophysical Research Communications , 630 :57 , 2022 |
Abstract : Brooks_2022_Biochem.Biophys.Res.Commun_630_57 |
ESTHER : Brooks_2022_Biochem.Biophys.Res.Commun_630_57 |
PubMedSearch : Brooks_2022_Biochem.Biophys.Res.Commun_630_57 |
PubMedID: 36148729 |
Gene_locus related to this paper: myctu-ym24 |
Title : Polysaccharide utilization loci-driven enzyme discovery reveals BD-FAE: a bifunctional feruloyl and acetyl xylan esterase active on complex natural xylans - Hameleers_2021_Biotechnol.Biofuels_14_127 |
Author(s) : Hameleers L , Penttinen L , Ikonen M , Jaillot L , Faure R , Terrapon N , Deuss PJ , Hakulinen N , Master ER , Jurak E |
Ref : Biotechnol Biofuels , 14 :127 , 2021 |
Abstract : Hameleers_2021_Biotechnol.Biofuels_14_127 |
ESTHER : Hameleers_2021_Biotechnol.Biofuels_14_127 |
PubMedSearch : Hameleers_2021_Biotechnol.Biofuels_14_127 |
PubMedID: 34059129 |
Gene_locus related to this paper: 9zzzz-6XYC |
Title : Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor - McLuskey_2010_J.Biol.Chem_285_39249 |
Author(s) : McLuskey K , Paterson NG , Bland ND , Isaacs NW , Mottram JC |
Ref : Journal of Biological Chemistry , 285 :39249 , 2010 |
Abstract : McLuskey_2010_J.Biol.Chem_285_39249 |
ESTHER : McLuskey_2010_J.Biol.Chem_285_39249 |
PubMedSearch : McLuskey_2010_J.Biol.Chem_285_39249 |
PubMedID: 20926390 |
Gene_locus related to this paper: leima-OPB |
Title : Structural characterization and reversal of the natural organophosphate resistance of a D-type esterase, Saccharomyces cerevisiae S-formylglutathione hydrolase - Legler_2008_Biochemistry_47_9592 |
Author(s) : Legler PM , Kumaran D , Swaminathan S , Studier FW , Millard CB |
Ref : Biochemistry , 47 :9592 , 2008 |
Abstract : Legler_2008_Biochemistry_47_9592 |
ESTHER : Legler_2008_Biochemistry_47_9592 |
PubMedSearch : Legler_2008_Biochemistry_47_9592 |
PubMedID: 18707125 |
Gene_locus related to this paper: yeast-yjg8 |
Title : Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV - Engel_2006_J.Mol.Biol_355_768 |
Author(s) : Engel M , Hoffmann T , Manhart S , Heiser U , Chambre S , Huber R , Demuth HU , Bode W |
Ref : Journal of Molecular Biology , 355 :768 , 2006 |
Abstract : Engel_2006_J.Mol.Biol_355_768 |
ESTHER : Engel_2006_J.Mol.Biol_355_768 |
PubMedSearch : Engel_2006_J.Mol.Biol_355_768 |
PubMedID: 16330047 |
Gene_locus related to this paper: pig-dpp4 |
Array ( [id] => 3720 [inhibitor] => AEBSF [type] => Array ( [0] => Sulfur Compound [1] => Sulfonyl ) [other_name] => Array ( [0] => 4-(2-Aminoethyl)benzenesulfonyl fluoride [1] => Pefabloc [2] => 4-(2-Aminoethyl)benzenesulfonylfluoride [3] => Benzenesulfonyl fluoride, 4-(2-aminoethyl)- ) [chemical_nomenclature] => 4-(2-aminoethyl)benzenesulfonyl fluoride [formula] => C8H10FNO2S [cas_number] => 34284-75-8 [mw] => 203.23 [pick_me_to_call] => display_script [kinetic_parameter] => [paper] => McLuskey_2010_J.Biol.Chem_285_39249 || Engel_2006_J.Mol.Biol_355_768 || Legler_2008_Biochemistry_47_9592 || Brooks_2022_Biochem.Biophys.Res.Commun_630_57 || Hameleers_2021_Biotechnol.Biofuels_14_127 [comment] => serine protease inhibitor [gene_locus] => pig-dpp4 || leima-OPB || halo1-d0lmj0 || human-FAP || myctu-ym24 [kin_inhibitor] => [cid] => 1701 [family] => S9N_PREPL_Peptidase_S9 || 5_AlphaBeta_hydrolase || DPP4N_Peptidase_S9 || Tiancimycin-TnmK-Tripeptidase-HIP [inchikey] => MGSKVZWGBWPBTF-UHFFFAOYSA-N [canonicalsmiles] => C1=CC(=CC=C1CCN)S(=O)(=O)F [inchi] => InChI=1S\/C8H10FNO2S\/c9-13(11,12)8-3-1-7(2-4-8)5-6-10\/h1-4H,5-6,10H2 [wikipedia] => [iupharlig] => [structure] => [substrate] => [interact_gene_locus] => [mutation] => [comment2] => [extoxnet] => [news] => [theoretical_model] => )