Barrangou R

References (11)

Title : Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera - Sun_2015_Nat.Commun_6_8322
Author(s) : Sun Z , Harris HM , McCann A , Guo C , Argimon S , Zhang W , Yang X , Jeffery IB , Cooney JC , Kagawa TF , Liu W , Song Y , Salvetti E , Wrobel A , Rasinkangas P , Parkhill J , Rea MC , O'Sullivan O , Ritari J , Douillard FP , Paul Ross R , Yang R , Briner AE , Felis GE , de Vos WM , Barrangou R , Klaenhammer TR , Caufield PW , Cui Y , Zhang H , O'Toole PW
Ref : Nat Commun , 6 :8322 , 2015
Abstract : Lactobacilli are a diverse group of species that occupy diverse nutrient-rich niches associated with humans, animals, plants and food. They are used widely in biotechnology and food preservation, and are being explored as therapeutics. Exploiting lactobacilli has been complicated by metabolic diversity, unclear species identity and uncertain relationships between them and other commercially important lactic acid bacteria. The capacity for biotransformations catalysed by lactobacilli is an untapped biotechnology resource. Here we report the genome sequences of 213 Lactobacillus strains and associated genera, and their encoded genetic catalogue for modifying carbohydrates and proteins. In addition, we describe broad and diverse presence of novel CRISPR-Cas immune systems in lactobacilli that may be exploited for genome editing. We rationalize the phylogenomic distribution of host interaction factors and bacteriocins that affect their natural and industrial environments, and mechanisms to withstand stress during technological processes. We present a robust phylogenomic framework of existing species and for classifying new species.
ESTHER : Sun_2015_Nat.Commun_6_8322
PubMedSearch : Sun_2015_Nat.Commun_6_8322
PubMedID: 26415554
Gene_locus related to this paper: 9laco-a0a0r1hz65 , 9laco-a0a0r1j1t4 , 9laco-a0a0r1j3p0 , 9laco-a0a0r1k3i0 , 9laco-a0a0r1k563 , 9laco-a0a0r1kgb3 , 9laco-a0a0r1kji2 , 9laco-a0a0r1kwq5 , 9laco-a0a0r1l700 , 9laco-a0a0r1p6l8 , 9laco-a0a0r1q939 , 9laco-a0a0r1qv39 , 9laco-a0a0r1wj75 , laccl-a0a0r2bne3 , 9laco-a0a0r2dnk9 , 9laco-a0a0r2ds70 , 9laco-a0a0r2k127 , 9laco-a0a0r2lee7 , 9laco-a0a0r2lqt2 , 9laco-a0a0r2m354 , 9laco-a0a0r2n9f2 , 9laco-a0a0r2nrk2 , lacze-a0a0r1ekw6 , 9laco-a0a0r1ju11 , 9laco-a0a0r1k516 , 9laco-a0a0r1leq9 , 9laco-a0a0r1lul8 , 9laco-a0a0r1lzg4 , 9laco-a0a0r1mhp8 , 9laco-a0a0r1mjt1 , 9laco-a0a0r1nv21 , 9laco-a0a0r1q1p6 , 9laco-a0a0r1qm41 , 9laco-a0a0r1qs58 , 9laco-a0a0r1rgu0 , 9laco-a0a0r1tg12 , 9laco-a0a0r1u777 , 9laco-a0a0r1ufv3 , 9laco-a0a0r1ul77 , 9laco-a0a0r1vad0 , 9laco-a0a0r1w3f4 , 9laco-a0a0r1w9r8 , 9laco-a0a0r1wpq2 , 9laco-a0a0r1x2g3 , 9laco-a0a0r2abe6 , 9laco-a0a0r2b6w1 , 9laco-a0a0r2b8g1 , 9laco-a0a0r2ch10 , 9laco-a0a0r2cld6 , 9laco-a0a0r2cv38 , 9laco-a0a0r2d3x3 , 9laco-a0a0r2dct2 , 9laco-a0a0r2flt3 , 9laco-a0a0r2frk5 , 9laco-a0a0r2guq4 , 9firm-a0a0r2h5m0 , weivi-a0a0r2h8r4 , 9lact-a0a0r2hnx4 , 9lact-a0a0r2jkt6 , 9lact-a0a0r2jmz1 , 9laco-a0a0r2jwg5 , 9laco-a0a0r2jxu0 , 9laco-a0a0r2jxw0 , lacam-a0a0r2kgt3 , 9laco-a0a0r2kx86 , 9laco-a0a0r2mxi6 , 9laco-a0a0r1vln2 , 9laco-a0a0r2ca25 , 9laco-a0a0r1zjs2 , weipa-c5rbw8

Title : Complete Genome Sequence of Probiotic Strain Lactobacillus acidophilus La-14 - Stahl_2013_Genome.Announc_1_E00376
Author(s) : Stahl B , Barrangou R
Ref : Genome Announc , 1 : , 2013
Abstract : We present the 1,991,830-bp complete genome sequence of Lactobacillus acidophilus strain La-14 (SD-5212). Comparative genomic analysis revealed 99.98% similarity overall to the L. acidophilus NCFM genome. Globally, 111 single nucleotide polymorphisms (SNPs) (95 SNPs, 16 indels) were observed throughout the genome. Also, a 416-bp deletion in the LA14_1146 sugar ABC transporter was identified.
ESTHER : Stahl_2013_Genome.Announc_1_E00376
PubMedSearch : Stahl_2013_Genome.Announc_1_E00376
PubMedID: 23788546
Gene_locus related to this paper: lacac-pip , lache-prolinase

Title : Phylogenetic diversity of the enteric pathogen Salmonella enterica subsp. enterica inferred from genome-wide reference-free SNP characters - Timme_2013_Genome.Biol.Evol_5_2109
Author(s) : Timme RE , Pettengill JB , Allard MW , Strain E , Barrangou R , Wehnes C , Van Kessel JS , Karns JS , Musser SM , Brown EW
Ref : Genome Biol Evol , 5 :2109 , 2013
Abstract : The enteric pathogen Salmonella enterica is one of the leading causes of foodborne illness in the world. The species is extremely diverse, containing more than 2,500 named serovars that are designated for their unique antigen characters and pathogenicity profiles-some are known to be virulent pathogens, while others are not. Questions regarding the evolution of pathogenicity, significance of antigen characters, diversity of clustered regularly interspaced short palindromic repeat (CRISPR) loci, among others, will remain elusive until a strong evolutionary framework is established. We present the first large-scale S. enterica subsp. enterica phylogeny inferred from a new reference-free k-mer approach of gathering single nucleotide polymorphisms (SNPs) from whole genomes. The phylogeny of 156 isolates representing 78 serovars (102 were newly sequenced) reveals two major lineages, each with many strongly supported sublineages. One of these lineages is the S. Typhi group; well nested within the phylogeny. Lineage-through-time analyses suggest there have been two instances of accelerated rates of diversification within the subspecies. We also found that antigen characters and CRISPR loci reveal different evolutionary patterns than that of the phylogeny, suggesting that a horizontal gene transfer or possibly a shared environmental acquisition might have influenced the present character distribution. Our study also shows the ability to extract reference-free SNPs from a large set of genomes and then to use these SNPs for phylogenetic reconstruction. This automated, annotation-free approach is an important step forward for bacterial disease tracking and in efficiently elucidating the evolutionary history of highly clonal organisms.
ESTHER : Timme_2013_Genome.Biol.Evol_5_2109
PubMedSearch : Timme_2013_Genome.Biol.Evol_5_2109
PubMedID: 24158624
Gene_locus related to this paper: salty-STY1441 , salty-ycfp

Title : Bifidobacterium animalis subsp. lactis ATCC 27673 is a genomically unique strain within its conserved subspecies - Loquasto_2013_Appl.Environ.Microbiol_79_6903
Author(s) : Loquasto JR , Barrangou R , Dudley EG , Stahl B , Chen C , Roberts RF
Ref : Applied Environmental Microbiology , 79 :6903 , 2013
Abstract : Many strains of Bifidobacterium animalis subsp. lactis are considered health-promoting probiotic microorganisms and are commonly formulated into fermented dairy foods. Analyses of previously sequenced genomes of B. animalis subsp. lactis have revealed little genetic diversity, suggesting that it is a monomorphic subspecies. However, during a multilocus sequence typing survey of Bifidobacterium, it was revealed that B. animalis subsp. lactis ATCC 27673 gave a profile distinct from that of the other strains of the subspecies. As part of an ongoing study designed to understand the genetic diversity of this subspecies, the genome of this strain was sequenced and compared to other sequenced genomes of B. animalis subsp. lactis and B. animalis subsp. animalis. The complete genome of ATCC 27673 was 1,963,012 bp, contained 1,616 genes and 4 rRNA operons, and had a G+C content of 61.55%. Comparative analyses revealed that the genome of ATCC 27673 contained six distinct genomic islands encoding 83 open reading frames not found in other strains of the same subspecies. In four islands, either phage or mobile genetic elements were identified. In island 6, a novel clustered regularly interspaced short palindromic repeat (CRISPR) locus which contained 81 unique spacers was identified. This type I-E CRISPR-cas system differs from the type I-C systems previously identified in this subspecies, representing the first identification of a different system in B. animalis subsp. lactis. This study revealed that ATCC 27673 is a strain of B. animalis subsp. lactis with novel genetic content and suggests that the lack of genetic variability observed is likely due to the repeated sequencing of a limited number of widely distributed commercial strains.
ESTHER : Loquasto_2013_Appl.Environ.Microbiol_79_6903
PubMedSearch : Loquasto_2013_Appl.Environ.Microbiol_79_6903
PubMedID: 23995933
Gene_locus related to this paper: bifan-b2eck9

Title : Analysis of the Lactobacillus casei supragenome and its influence in species evolution and lifestyle adaptation - Broadbent_2012_BMC.Genomics_13_533
Author(s) : Broadbent JR , Neeno-Eckwall EC , Stahl B , Tandee K , Cai H , Morovic W , Horvath P , Heidenreich J , Perna NT , Barrangou R , Steele JL
Ref : BMC Genomics , 13 :533 , 2012
Abstract : BACKGROUND: The broad ecological distribution of L. casei makes it an insightful subject for research on genome evolution and lifestyle adaptation. To explore evolutionary mechanisms that determine genomic diversity of L. casei, we performed comparative analysis of 17 L. casei genomes representing strains collected from dairy, plant, and human sources.
RESULTS: Differences in L. casei genome inventory revealed an open pan-genome comprised of 1,715 core and 4,220 accessory genes. Extrapolation of pan-genome data indicates L. casei has a supragenome approximately 3.2 times larger than the average genome of individual strains. Evidence suggests horizontal gene transfer from other bacterial species, particularly lactobacilli, has been important in adaptation of L. casei to new habitats and lifestyles, but evolution of dairy niche specialists also appears to involve gene decay.
CONCLUSIONS: Genome diversity in L. casei has evolved through gene acquisition and decay. Acquisition of foreign genomic islands likely confers a fitness benefit in specific habitats, notably plant-associated niches. Loss of unnecessary ancestral traits in strains collected from bacterial-ripened cheeses supports the hypothesis that gene decay contributes to enhanced fitness in that niche. This study gives the first evidence for a L. casei supragenome and provides valuable insights into mechanisms for genome evolution and lifestyle adaptation of this ecologically flexible and industrially important lactic acid bacterium. Additionally, our data confirm the Distributed Genome Hypothesis extends to non-pathogenic, ecologically flexible species like L. casei.
ESTHER : Broadbent_2012_BMC.Genomics_13_533
PubMedSearch : Broadbent_2012_BMC.Genomics_13_533
PubMedID: 23035691
Gene_locus related to this paper: lacc3-q03b36 , laccb-b3wcx2 , lacrh-pepr , lacca-b5qt93 , lacca-k0n1x0 , lacpa-s2ter8 , lacpa-s2rz88

Title : Complete genome sequences of probiotic strains Bifidobacterium animalis subsp. lactis B420 and Bi-07 - Stahl_2012_J.Bacteriol_194_4131
Author(s) : Stahl B , Barrangou R
Ref : Journal of Bacteriology , 194 :4131 , 2012
Abstract : We present the complete genomes of Bifidobacterium animalis subsp. lactis B420 and Bi-07. Comparative genomic analysis with the type strain DSMZ10140 revealed 40 to 55 single nucleotide polymorphisms (SNPs) and an indel in a clustered regularly interspaced short palindromic repeat (CRISPR) locus. These genetic differences provide a molecular basis for strain typing within the two main phylogenetic groups of this monomorphic species.
ESTHER : Stahl_2012_J.Bacteriol_194_4131
PubMedSearch : Stahl_2012_J.Bacteriol_194_4131
PubMedID: 22815448
Gene_locus related to this paper: bifan-b2eck9 , bifan-b2e8c8

Title : Short communication: the complete genome sequence of Bifidobacterium animalis subspecies animalis ATCC 25527(T) and comparative analysis of growth in milk with B. animalis subspecies lactis DSM 10140(T) - Loquasto_2011_J.Dairy.Sci_94_5864
Author(s) : Loquasto JR , Barrangou R , Dudley EG , Roberts RF
Ref : J Dairy Sci , 94 :5864 , 2011
Abstract : The objective of this work was to sequence the genome of Bifidobacterium animalis ssp. animalis ATCC 25527(T), the subspecies most closely related to B. animalis ssp. lactis, some strains of which are widely added to dairy foods as probiotics. The complete 1,932,963-bp genome was determined by a combination of 454-shotgun sequencing and PCR gap closing, and the completed assembly was verified by comparison with a KpnI optical map. Comparative analysis of the B. animalis ssp. animalis ATCC 25527(T) and B. animalis ssp. lactis DSM 10140(T) genomes revealed high degrees of synteny and sequence homology. Comparative genomic analysis revealed 156 and 182 genes that were unique to and absent in the B. animalis ssp. animalis genome, respectively. Among these was a set of unique clustered regularly interspaced short palindromic repeats (CRISPR)-associated genes and a novel CRISPR locus containing 30 spacers in the genome of B. animalis ssp. animalis. Although previous researchers have suggested that one of the defining phenotypic differences between B. animalis ssp. animalis and B. animalis ssp. lactis is the ability of the latter to grow in milk and milk-based media, the differential gene content did not provide insights to explain these differences. Furthermore, growth and acid production in milk and milk-based media did not differ significantly between B. animalis ssp. lactis (DSM 10140(T) and Bl04) and B. animalis ssp. animalis (ATCC 25527(T)). Growth of these strains in supplemented milk suggested that growth was limited by a lack of available low-molecular-weight nitrogen in the 3 strains examined.
ESTHER : Loquasto_2011_J.Dairy.Sci_94_5864
PubMedSearch : Loquasto_2011_J.Dairy.Sci_94_5864
PubMedID: 22118077
Gene_locus related to this paper: bifan-b2eck9

Title : Comparison of the complete genome sequences of Bifidobacterium animalis subsp. lactis DSM 10140 and Bl-04 - Barrangou_2009_J.Bacteriol_191_4144
Author(s) : Barrangou R , Briczinski EP , Traeger LL , Loquasto JR , Richards M , Horvath P , Coute-Monvoisin AC , Leyer G , Rendulic S , Steele JL , Broadbent JR , Oberg T , Dudley EG , Schuster S , Romero DA , Roberts RF
Ref : Journal of Bacteriology , 191 :4144 , 2009
Abstract : Bifidobacteria are important members of the human gut flora, especially in infants. Comparative genomic analysis of two Bifidobacterium animalis subsp. lactis strains revealed evolution by internal deletion of consecutive spacer-repeat units within a novel clustered regularly interspaced short palindromic repeat locus, which represented the largest differential content between the two genomes. Additionally, 47 single nucleotide polymorphisms were identified, consisting primarily of nonsynonymous mutations, indicating positive selection and/or recent divergence. A particular nonsynonymous mutation in a putative glucose transporter was linked to a negative phenotypic effect on the ability of the variant to catabolize glucose, consistent with a modification in the predicted protein transmembrane topology. Comparative genome sequence analysis of three Bifidobacterium species provided a core genome set of 1,117 orthologs complemented by a pan-genome of 2,445 genes. The genome sequences of the intestinal bacterium B. animalis subsp. lactis provide insights into rapid genome evolution and the genetic basis for adaptation to the human gut environment, notably with regard to catabolism of dietary carbohydrates, resistance to bile and acid, and interaction with the intestinal epithelium. The high degree of genome conservation observed between the two strains in terms of size, organization, and sequence is indicative of a genomically monomorphic subspecies and explains the inability to differentiate the strains by standard techniques such as pulsed-field gel electrophoresis.
ESTHER : Barrangou_2009_J.Bacteriol_191_4144
PubMedSearch : Barrangou_2009_J.Bacteriol_191_4144
PubMedID: 19376856
Gene_locus related to this paper: bifan-b2ea73 , bifan-b2eam2 , bifan-b2eck9 , bifas-c6ahs7 , biflb-c6a5u1 , bifa0-b8dw94 , bifan-b2e8c8

Title : Comparative genomics of the lactic acid bacteria - Makarova_2006_Proc.Natl.Acad.Sci.U.S.A_103_15611
Author(s) : Makarova K , Slesarev A , Wolf Y , Sorokin A , Mirkin B , Koonin E , Pavlov A , Pavlova N , Karamychev V , Polouchine N , Shakhova V , Grigoriev I , Lou Y , Rohksar D , Lucas S , Huang K , Goodstein DM , Hawkins T , Plengvidhya V , Welker D , Hughes J , Goh Y , Benson A , Baldwin K , Lee JH , Diaz-Muniz I , Dosti B , Smeianov V , Wechter W , Barabote R , Lorca G , Altermann E , Barrangou R , Ganesan B , Xie Y , Rawsthorne H , Tamir D , Parker C , Breidt F , Broadbent J , Hutkins R , O'Sullivan D , Steele J , Unlu G , Saier M , Klaenhammer T , Richardson P , Kozyavkin S , Weimer B , Mills D
Ref : Proc Natl Acad Sci U S A , 103 :15611 , 2006
Abstract : Lactic acid-producing bacteria are associated with various plant and animal niches and play a key role in the production of fermented foods and beverages. We report nine genome sequences representing the phylogenetic and functional diversity of these bacteria. The small genomes of lactic acid bacteria encode a broad repertoire of transporters for efficient carbon and nitrogen acquisition from the nutritionally rich environments they inhabit and reflect a limited range of biosynthetic capabilities that indicate both prototrophic and auxotrophic strains. Phylogenetic analyses, comparison of gene content across the group, and reconstruction of ancestral gene sets indicate a combination of extensive gene loss and key gene acquisitions via horizontal gene transfer during the coevolution of lactic acid bacteria with their habitats.
ESTHER : Makarova_2006_Proc.Natl.Acad.Sci.U.S.A_103_15611
PubMedSearch : Makarova_2006_Proc.Natl.Acad.Sci.U.S.A_103_15611
PubMedID: 17030793
Gene_locus related to this paper: 9laco-c0xef2 , lacba-pepx , lacba-q03pm4 , lacba-q03sl1 , lacc3-pepx , lacc3-q03b36 , lacc3-q033u9 , lacc3-q035l1 , lacc3-q036j3 , lacc3-q036j8 , laccb-b3wcx2 , lacda-q1g8l1 , lacdb-q04b33 , lacdb-q04bn2 , lacdb-q04ci8 , lacdb-q04cw3 , lacdl-pepx , lacdl-pip , lacga-q040j4 , lacga-q040j9 , lacga-q040s2 , lacga-q042h9 , lacga-q043a3 , lacga-q043m1 , lacga-q045l3 , lacga-q046w1 , lacga-q047a5 , lacjo-q74hh0 , lacjo-q74ii3 , lacla-pepx , laclk-d2bl62 , lacls-q02y15 , lacls-q030e4 , lacls-q030p2 , lacrh-pepr , leumc-c2kjv5 , leumm-q03x93 , leumm-q03y60 , leumm-q03y71 , leumm-q03z72 , oenob-q04d10 , oenob-q04f06 , oenob-q04f19 , oenob-q04fw8 , oenob-q04ga3 , oenob-q04h47 , oenoe-a0nif9 , oenoe-a0nl98 , oenoe-d3lb54 , pedpa-pepx , pedpa-q03gh4 , pedpa-q03h47 , pedpa-q03hj2 , strt1-q5lz16 , strt1-q5lza1 , strt2-q5m420 , strtr-pepx , oenoe-k6pl10 , lacba-pip , lacca-k0n1x0 , lacpa-s2ter8 , lacpa-s2rz88 , pedpa-q03hz6 , oenob-q04dp7

Title : Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM - Altermann_2005_Proc.Natl.Acad.Sci.U.S.A_102_3906
Author(s) : Altermann E , Russell WM , Azcarate-Peril MA , Barrangou R , Buck BL , McAuliffe O , Souther N , Dobson A , Duong T , Callanan M , Lick S , Hamrick A , Cano R , Klaenhammer TR
Ref : Proc Natl Acad Sci U S A , 102 :3906 , 2005
Abstract : Lactobacillus acidophilus NCFM is a probiotic bacterium that has been produced commercially since 1972. The complete genome is 1,993,564 nt and devoid of plasmids. The average GC content is 34.71% with 1,864 predicted ORFs, of which 72.5% were functionally classified. Nine phage-related integrases were predicted, but no complete prophages were found. However, three unique regions designated as potential autonomous units (PAUs) were identified. These units resemble a unique structure and bear characteristics of both plasmids and phages. Analysis of the three PAUs revealed the presence of two R/M systems and a prophage maintenance system killer protein. A spacers interspersed direct repeat locus containing 32 nearly perfect 29-bp repeats was discovered and may provide a unique molecular signature for this organism. In silico analyses predicted 17 transposase genes and a chromosomal locus for lactacin B, a class II bacteriocin. Several mucus- and fibronectin-binding proteins, implicated in adhesion to human intestinal cells, were also identified. Gene clusters for transport of a diverse group of carbohydrates, including fructooligosaccharides and raffinose, were present and often accompanied by transcriptional regulators of the lacI family. For protein degradation and peptide utilization, the organism encoded 20 putative peptidases, homologs for PrtP and PrtM, and two complete oligopeptide transport systems. Nine two-component regulatory systems were predicted, some associated with determinants implicated in bacteriocin production and acid tolerance. Collectively, these features within the genome sequence of L. acidophilus are likely to contribute to the organisms' gastric survival and promote interactions with the intestinal mucosa and microbiota.
ESTHER : Altermann_2005_Proc.Natl.Acad.Sci.U.S.A_102_3906
PubMedSearch : Altermann_2005_Proc.Natl.Acad.Sci.U.S.A_102_3906
PubMedID: 15671160
Gene_locus related to this paper: lacac-q5fhs3 , lacac-q5fhw5 , lacac-q5fi30 , lacac-q5fin2 , lacac-q5fj74 , lacac-q5fje2 , lacac-q5fje7 , lacac-q5fk68 , lacac-q5fkd4 , lacac-q5fkk4 , lacac-q5fkq4 , lacac-q5flb5 , lacac-q5flg1 , lacac-q5fmp9 , lacac-q5fmq3 , lacac-pip , lacac-q5fmz8 , lache-pepx , lache-prolinase

Title : The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533 - Pridmore_2004_Proc.Natl.Acad.Sci.U.S.A_101_2512
Author(s) : Pridmore RD , Berger B , Desiere F , Vilanova D , Barretto C , Pittet AC , Zwahlen MC , Rouvet M , Altermann E , Barrangou R , Mollet B , Mercenier A , Klaenhammer T , Arigoni F , Schell MA
Ref : Proc Natl Acad Sci U S A , 101 :2512 , 2004
Abstract : Lactobacillus johnsonii NCC 533 is a member of the acidophilus group of intestinal lactobacilli that has been extensively studied for their "probiotic" activities that include, pathogen inhibition, epithelial cell attachment, and immunomodulation. To gain insight into its physiology and identify genes potentially involved in interactions with the host, we sequenced and analyzed the 1.99-Mb genome of L. johnsonii NCC 533. Strikingly, the organism completely lacked genes encoding biosynthetic pathways for amino acids, purine nucleotides, and most cofactors. In apparent compensation, a remarkable number of uncommon and often duplicated amino acid permeases, peptidases, and phosphotransferase-type transporters were discovered, suggesting a strong dependency of NCC 533 on the host or other intestinal microbes to provide simple monomeric nutrients. Genome analysis also predicted an abundance (>12) of large and unusual cell-surface proteins, including fimbrial subunits, which may be involved in adhesion to glycoproteins or other components of mucin, a characteristic expected to affect persistence in the gastrointestinal tract (GIT). Three bile salt hydrolases and two bile acid transporters, proteins apparently critical for GIT survival, were also detected. In silico genome comparisons with the >95% complete genome sequence of the closely related Lactobacillus gasseri revealed extensive synteny punctuated by clear-cut insertions or deletions of single genes or operons. Many of these regions of difference appear to encode metabolic or structural components that could affect the organisms competitiveness or interactions with the GIT ecosystem.
ESTHER : Pridmore_2004_Proc.Natl.Acad.Sci.U.S.A_101_2512
PubMedSearch : Pridmore_2004_Proc.Natl.Acad.Sci.U.S.A_101_2512
PubMedID: 14983040
Gene_locus related to this paper: lacga-q043a3 , lacga-q047a5 , lacjo-q74hh0 , lacjo-q74hk5 , lacjo-q74hz2 , lacjo-q74ii3 , lacjo-q74ik2 , lacjo-q74j82 , lacjo-q74j86 , lacjo-q74ji6 , lacjo-q74k55 , lacjo-q74kk4 , lacjo-q74kr9 , lacjo-q74lt2 , lacjo-q74lt6 , lacjo-q74m20