Full name : Goldsmith Moshe
First name : Moshe
Mail : Weizmann Institute of Science\; Biological Chemistry\; Herzel st.\; Rehovot\; 76100
Zip Code :
City :
Country : Israel
Email : moshe.goldsmith@weizmann.ac.il
Phone : +972523324675
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Comment
| Title : Catalytic bioscavengers as countermeasures against organophosphate nerve agents - Goldsmith_2018_Chem.Biol.Interact_292_50 |
| Author(s) : Goldsmith M , Ashani Y |
| Ref : Chemico-Biological Interactions , 292 :50 , 2018 |
| Abstract : |
| PubMedSearch : Goldsmith_2018_Chem.Biol.Interact_292_50 |
| PubMedID: 29990481 |
| Title : Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro - Goldsmith_2016_Arch.Toxicol_90_2711 |
| Author(s) : Goldsmith M , Eckstein S , Ashani Y , Greisen P, Jr. , Leader H , Sussman JL , Aggarwal N , Ovchinnikov S , Tawfik DS , Baker D , Thiermann H , Worek F |
| Ref : Archives of Toxicology , 90 :2711 , 2016 |
| Abstract : |
| PubMedSearch : Goldsmith_2016_Arch.Toxicol_90_2711 |
| PubMedID: 26612364 |
| Title : Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection - Wille_2016_Toxicol.Lett_258_198 |
| Author(s) : Wille T , Neumaier K , Koller M , Ehinger C , Aggarwal N , Ashani Y , Goldsmith M , Sussman JL , Tawfik DS , Thiermann H , Worek F |
| Ref : Toxicol Lett , 258 :198 , 2016 |
| Abstract : |
| PubMedSearch : Wille_2016_Toxicol.Lett_258_198 |
| PubMedID: 27397758 |
| Title : In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications - Ashani_2016_Chem.Biol.Interact_259_252 |
| Author(s) : Ashani Y , Leader H , Aggarwal N , Silman I , Worek F , Sussman JL , Goldsmith M |
| Ref : Chemico-Biological Interactions , 259 :252 , 2016 |
| Abstract : |
| PubMedSearch : Ashani_2016_Chem.Biol.Interact_259_252 |
| PubMedID: 27163850 |
| Title : Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability - Goldenzweig_2016_Mol.Cell_63_337 |
| Author(s) : Goldenzweig A , Goldsmith M , Hill SE , Gertman O , Laurino P , Ashani Y , Dym O , Unger T , Albeck S , Prilusky J , Lieberman RL , Aharoni A , Silman I , Sussman JL , Tawfik DS , Fleishman SJ |
| Ref : Mol Cell , 63 :337 , 2016 |
| Abstract : |
| PubMedSearch : Goldenzweig_2016_Mol.Cell_63_337 |
| PubMedID: 27425410 |
| Gene_locus related to this paper: human-ACHE |
| Title : A new post-intoxication treatment of paraoxon and parathion poisonings using an evolved PON1 variant and recombinant GOT1 - Goldsmith_2016_Chem.Biol.Interact_259_242 |
| Author(s) : Goldsmith M , Ashani Y , Margalit R , Nyska A , Mirelman D , Tawfik DS |
| Ref : Chemico-Biological Interactions , 259 :242 , 2016 |
| Abstract : |
| PubMedSearch : Goldsmith_2016_Chem.Biol.Interact_259_242 |
| PubMedID: 27256520 |
| Title : Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study - Worek_2014_Toxicol.Lett_231_45 |
| Author(s) : Worek F , Seeger T , Reiter G , Goldsmith M , Ashani Y , Leader H , Sussman JL , Aggarwal N , Thiermann H , Tawfik DS |
| Ref : Toxicol Lett , 231 :45 , 2014 |
| Abstract : |
| PubMedSearch : Worek_2014_Toxicol.Lett_231_45 |
| PubMedID: 25195526 |
| Title : Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro - Worek_2014_Arch.Toxicol_88_1257 |
| Author(s) : Worek F , Seeger T , Goldsmith M , Ashani Y , Leader H , Sussman JL , Tawfik DS , Thiermann H , Wille T |
| Ref : Archives of Toxicology , 88 :1257 , 2014 |
| Abstract : |
| PubMedSearch : Worek_2014_Arch.Toxicol_88_1257 |
| PubMedID: 24477626 |
| Title : Enzyme engineering by targeted libraries - Goldsmith_2013_Methods.Enzymol_523_257 |
| Author(s) : Goldsmith M , Tawfik DS |
| Ref : Methods Enzymol , 523 :257 , 2013 |
| Abstract : |
| PubMedSearch : Goldsmith_2013_Methods.Enzymol_523_257 |
| PubMedID: 23422434 |
| Title : Directed enzyme evolution: beyond the low-hanging fruit - Goldsmith_2012_Curr.Opin.Struct.Biol_22_406 |
| Author(s) : Goldsmith M , Tawfik DS |
| Ref : Current Opinion in Structural Biology , 22 :406 , 2012 |
| Abstract : |
| PubMedSearch : Goldsmith_2012_Curr.Opin.Struct.Biol_22_406 |
| PubMedID: 22579412 |
| Title : Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis - Khare_2012_Nat.Chem.Biol_8_294 |
| Author(s) : Khare SD , Kipnis Y , Greisen P, Jr. , Takeuchi R , Ashani Y , Goldsmith M , Song Y , Gallaher JL , Silman I , Leader H , Sussman JL , Stoddard BL , Tawfik DS , Baker D |
| Ref : Nat Chemical Biology , 8 :294 , 2012 |
| Abstract : |
| PubMedSearch : Khare_2012_Nat.Chem.Biol_8_294 |
| PubMedID: 22306579 |
| Title : Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification - Goldsmith_2012_Chem.Biol_19_456 |
| Author(s) : Goldsmith M , Ashani Y , Simo Y , Ben-David M , Leader H , Silman I , Sussman JL , Tawfik DS |
| Ref : Chemical Biology , 19 :456 , 2012 |
| Abstract : |
| PubMedSearch : Goldsmith_2012_Chem.Biol_19_456 |
| PubMedID: 22520752 |
| Title : In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases - Ashani_2011_Toxicol.Lett_206_24 |
| Author(s) : Ashani Y , Goldsmith M , Leader H , Silman I , Sussman JL , Tawfik DS |
| Ref : Toxicol Lett , 206 :24 , 2011 |
| Abstract : |
| PubMedSearch : Ashani_2011_Toxicol.Lett_206_24 |
| PubMedID: 21807078 |
| Title : Directed evolution of hydrolases for prevention of G-type nerve agent intoxication - Gupta_2011_Nat.Chem.Biol_7_120 |
| Author(s) : Gupta RD , Goldsmith M , Ashani Y , Simo Y , Mullokandov G , Bar H , Ben-David M , Leader H , Margalit R , Silman I , Sussman JL , Tawfik DS |
| Ref : Nat Chemical Biology , 7 :120 , 2011 |
| Abstract : |
| PubMedSearch : Gupta_2011_Nat.Chem.Biol_7_120 |
| PubMedID: 21217689 |
| Title : Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers - Ashani_2010_Chem.Biol.Interact_187_362 |
| Author(s) : Ashani Y , Gupta RD , Goldsmith M , Silman I , Sussman JL , Tawfik DS , Leader H |
| Ref : Chemico-Biological Interactions , 187 :362 , 2010 |
| Abstract : |
| PubMedSearch : Ashani_2010_Chem.Biol.Interact_187_362 |
| PubMedID: 20303930 |
| Title : Potential role of phenotypic mutations in the evolution of protein expression and stability - Goldsmith_2009_Proc.Natl.Acad.Sci.U.S.A_106_6197 |
| Author(s) : Goldsmith M , Tawfik DS |
| Ref : Proc Natl Acad Sci U S A , 106 :6197 , 2009 |
| Abstract : |
| PubMedSearch : Goldsmith_2009_Proc.Natl.Acad.Sci.U.S.A_106_6197 |
| PubMedID: 19339491 |