mouse-ppt

Mus musculus (Mouse) palmitoyl-protein thioesterase

Comment

some differences between Q9WTY3 Q9D681 O88531

Relationship

Family : Palmitoyl-protein_thioesterase

Block : X

Position in NCBI Life Tree : Mus musculus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Sequence

Peptide

MMASSCSRRL LAAALLPWCC AAWALGHLDP PSPPPLVIWH GMGDSCCNPM SMGVIKKMVE KEIPGIYVLS LEIGKNMMED VENSFFLNVN VQVNMVCQIL EKDPKLQQGY NAIGFSQGGQ FLRAVAQRCP TPPMMTLISV GGQHQGVFGL PRCPGESSHI CDFIRKSLNA GAYSKLVQER LVQAQYWHDP IKESVYRNYS IFLADINQER CVNESYKKNL MALKKFVMVK FFNDSIVDPV DSEWFGFYRS GQAKETIPLQ ESTLYTEDRL GLKKMDKAGK LVFLAKEGDH LQISKEWFTA HIIPFLK

References (41)

Title : Synergistic effects of treating the spinal cord and brain in CLN1 disease - Shyng_2017_Proc.Natl.Acad.Sci.U.S.A_114_E5920
Author(s) : Shyng C , Nelvagal HR , Dearborn JT , Tyynela J , Schmidt RE , Sands MS , Cooper JD
Ref : Proc Natl Acad Sci U S A , 114 :E5920 , 2017
PubMedID: 28673981
Gene_locus related to this paper: mouse-ppt

Title : Fingolimod and Teriflunomide Attenuate Neurodegeneration in Mouse Models of Neuronal Ceroid Lipofuscinosis - Groh_2017_Mol.Ther_25_1889
Author(s) : Groh J , Berve K , Martini R
Ref : Mol Ther , 25 :1889 , 2017
PubMedID: 28506594
Gene_locus related to this paper: mouse-ppt

Title : Tissue-specific variation in nonsense mutant transcript level and drug-induced read-through efficiency in the Cln1(R151X) mouse model of INCL - Thada_2016_J.Cell.Mol.Med_20_381
Author(s) : Thada V , Miller JN , Kovacs AD , Pearce DA
Ref : J Cell Mol Med , 20 :381 , 2016
PubMedID: 26648046
Gene_locus related to this paper: mouse-ppt

Title : Sialoadhesin promotes neuroinflammation-related disease progression in two mouse models of CLN disease - Groh_2016_Glia_64_792
Author(s) : Groh J , Ribechini E , Stadler D , Schilling T , Lutz MB , Martini R
Ref : Glia , 64 :792 , 2016
PubMedID: 26775238
Gene_locus related to this paper: mouse-ppt

Title : Cln1 gene disruption in mice reveals a common pathogenic link between two of the most lethal childhood neurodegenerative lysosomal storage disorders - Chandra_2015_Hum.Mol.Genet_24_5416
Author(s) : Chandra G , Bagh MB , Peng S , Saha A , Sarkar C , Moralle M , Zhang Z , Mukherjee AB
Ref : Hum Mol Genet , 24 :5416 , 2015
PubMedID: 26160911
Gene_locus related to this paper: mouse-ppt

Title : Comprehensive functional characterization of murine infantile Batten disease including Parkinson-like behavior and dopaminergic markers - Dearborn_2015_Sci.Rep_5_12752
Author(s) : Dearborn JT , Harmon SK , Fowler SC , O'Malley KL , Taylor GT , Sands MS , Wozniak DF
Ref : Sci Rep , 5 :12752 , 2015
PubMedID: 26238334
Gene_locus related to this paper: mouse-ppt

Title : Intrathecal enzyme replacement therapy improves motor function and survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis - Lu_2015_Mol.Genet.Metab_116_98
Author(s) : Lu JY , Nelvagal HR , Wang L , Birnbaum SG , Cooper JD , Hofmann SL
Ref : Mol Genet Metab , 116 :98 , 2015
PubMedID: 25982063
Gene_locus related to this paper: mouse-ppt

Title : Mice homozygous for c.451C>T mutation in Cln1 gene recapitulate INCL phenotype - Bouchelion_2014_Ann.Clin.Transl.Neurol_1_1006
Author(s) : Bouchelion A , Zhang Z , Li Y , Qian H , Mukherjee AB
Ref : Ann Clin Transl Neurol , 1 :1006 , 2014
PubMedID: 25574475
Gene_locus related to this paper: mouse-ppt

Title : Neuroprotection and lifespan extension in Ppt1(-\/-) mice by NtBuHA: therapeutic implications for INCL - Sarkar_2013_Nat.Neurosci_16_1608
Author(s) : Sarkar C , Chandra G , Peng S , Zhang Z , Liu A , Mukherjee AB
Ref : Nat Neurosci , 16 :1608 , 2013
PubMedID: 24056696
Gene_locus related to this paper: mouse-ppt

Title : Treatment of the Ppt1(-\/-) mouse model of infantile neuronal ceroid lipofuscinosis with the N-methyl-D-aspartate (NMDA) receptor antagonist memantine - Finn_2013_J.Child.Neurol_28_1159
Author(s) : Finn R , Kovacs AD , Pearce DA
Ref : Journal of Child Neurology , 28 :1159 , 2013
PubMedID: 24014511
Gene_locus related to this paper: mouse-ppt

Title : Synergistic effects of central nervous system-directed gene therapy and bone marrow transplantation in the murine model of infantile neuronal ceroid lipofuscinosis - Macauley_2012_Ann.Neurol_71_797
Author(s) : Macauley SL , Roberts MS , Wong AM , McSloy F , Reddy AS , Cooper JD , Sands MS
Ref : Annals of Neurology , 71 :797 , 2012
PubMedID: 22368049
Gene_locus related to this paper: mouse-ppt

Title : Evaluation of neurodegeneration in a mouse model of infantile batten disease by magnetic resonance imaging and magnetic resonance spectroscopy - Munasinghe_2012_Neurodegener.Dis_9_159
Author(s) : Munasinghe J , Zhang Z , Kong E , Heffer A , Mukherjee AB
Ref : Neurodegener Dis , 9 :159 , 2012
PubMedID: 22327870
Gene_locus related to this paper: mouse-ppt

Title : Combination small molecule PPT1 mimetic and CNS-directed gene therapy as a treatment for infantile neuronal ceroid lipofuscinosis - Roberts_2012_J.Inherit.Metab.Dis_35_847
Author(s) : Roberts MS , Macauley SL , Wong AM , Yilmas D , Hohm S , Cooper JD , Sands MS
Ref : J Inherit Metab Dis , 35 :847 , 2012
PubMedID: 22310926
Gene_locus related to this paper: mouse-ppt

Title : The blood-brain barrier is disrupted in a mouse model of infantile neuronal ceroid lipofuscinosis: amelioration by resveratrol - Saha_2012_Hum.Mol.Genet_21_2233
Author(s) : Saha A , Sarkar C , Singh SP , Zhang Z , Munasinghe J , Peng S , Chandra G , Kong E , Mukherjee AB
Ref : Hum Mol Genet , 21 :2233 , 2012
PubMedID: 22331300
Gene_locus related to this paper: mouse-ppt

Title : Mouse models of neuronal ceroid lipofuscinoses: useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics - Shacka_2012_Brain.Res.Bull_88_43
Author(s) : Shacka JJ
Ref : Brain Research Bulletin , 88 :43 , 2012
PubMedID: 22502604
Gene_locus related to this paper: mouse-ppt

Title : Altered glutamate receptor function in the cerebellum of the Ppt1-\/- mouse, a murine model of infantile neuronal ceroid lipofuscinosis - Finn_2012_J.Neurosci.Res_90_367
Author(s) : Finn R , Kovacs AD , Pearce DA
Ref : Journal of Neuroscience Research , 90 :367 , 2012
PubMedID: 21971706
Gene_locus related to this paper: mouse-ppt

Title : Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl-protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis - Hu_2012_Mol.Genet.Metab_107_213
Author(s) : Hu J , Lu JY , Wong AM , Hynan LS , Birnbaum SG , Yilmaz DS , Streit BM , Lenartowicz EM , Thompson TC , Cooper JD , Hofmann SL
Ref : Mol Genet Metab , 107 :213 , 2012
PubMedID: 22704978
Gene_locus related to this paper: mouse-ppt

Title : In a model of Batten disease, palmitoyl protein thioesterase-1 deficiency is associated with brown adipose tissue and thermoregulation abnormalities - Khaibullina_2012_PLoS.One_7_e48733
Author(s) : Khaibullina A , Kenyon N , Guptill V , Quezado MM , Wang L , Koziol D , Wesley R , Moya PR , Zhang Z , Saha A , Mukherjee AB , Quezado ZM
Ref : PLoS ONE , 7 :e48733 , 2012
PubMedID: 23139814
Gene_locus related to this paper: mouse-ppt

Title : The role of attenuated astrocyte activation in infantile neuronal ceroid lipofuscinosis - Macauley_2011_J.Neurosci_31_15575
Author(s) : Macauley SL , Pekny M , Sands MS
Ref : Journal of Neuroscience , 31 :15575 , 2011
PubMedID: 22031903
Gene_locus related to this paper: mouse-ppt

Title : Omega-3 and omega-6 fatty acids suppress ER- and oxidative stress in cultured neurons and neuronal progenitor cells from mice lacking PPT1 - Kim_2010_Neurosci.Lett_479_292
Author(s) : Kim SJ , Zhang Z , Saha A , Sarkar C , Zhao Z , Xu Y , Mukherjee AB
Ref : Neuroscience Letters , 479 :292 , 2010
PubMedID: 20561933
Gene_locus related to this paper: mouse-ppt

Title : Human recombinant palmitoyl-protein thioesterase-1 (PPT1) for preclinical evaluation of enzyme replacement therapy for infantile neuronal ceroid lipofuscinosis - Lu_2010_Mol.Genet.Metab_99_374
Author(s) : Lu JY , Hu J , Hofmann SL
Ref : Mol Genet Metab , 99 :374 , 2010
PubMedID: 20036592
Gene_locus related to this paper: mouse-ppt

Title : Cerebellar pathology and motor deficits in the palmitoyl protein thioesterase 1-deficient mouse - Macauley_2009_Exp.Neurol_217_124
Author(s) : Macauley SL , Wozniak DF , Kielar C , Tan Y , Cooper JD , Sands MS
Ref : Experimental Neurology , 217 :124 , 2009
PubMedID: 19416667
Gene_locus related to this paper: mouse-ppt

Title : Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease - Kielar_2009_Hum.Mol.Genet_18_4066
Author(s) : Kielar C , Wishart TM , Palmer A , Dihanich S , Wong AM , Macauley SL , Chan CH , Sands MS , Pearce DA , Cooper JD , Gillingwater TH
Ref : Hum Mol Genet , 18 :4066 , 2009
PubMedID: 19640925
Gene_locus related to this paper: mouse-ppt

Title : RAGE signaling contributes to neuroinflammation in infantile neuronal ceroid lipofuscinosis - Saha_2008_FEBS.Lett_582_3823
Author(s) : Saha A , Kim SJ , Zhang Z , Lee YC , Sarkar C , Tsai PC , Mukherjee AB
Ref : FEBS Letters , 582 :3823 , 2008
PubMedID: 18948101
Gene_locus related to this paper: mouse-ppt , human-PPT1

Title : A murine model of infantile neuronal ceroid lipofuscinosis-ultrastructural evaluation of storage in the central nervous system and viscera - Galvin_2008_Pediatr.Dev.Pathol_11_185
Author(s) : Galvin N , Vogler C , Levy B , Kovacs A , Griffey M , Sands MS
Ref : Pediatr Dev Pathol , 11 :185 , 2008
PubMedID: 17990914
Gene_locus related to this paper: mouse-ppt

Title : Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and mice - Kim_2008_J.Clin.Invest_118_3075
Author(s) : Kim SJ , Zhang Z , Sarkar C , Tsai PC , Lee YC , Dye L , Mukherjee AB
Ref : J Clinical Investigation , 118 :3075 , 2008
PubMedID: 18704195
Gene_locus related to this paper: mouse-ppt , human-PPT1

Title : Deficiency of the INCL protein Ppt1 results in changes in ectopic F1-ATP synthase and altered cholesterol metabolism - Lyly_2008_Hum.Mol.Genet_17_1406
Author(s) : Lyly A , Marjavaara SK , Kyttala A , Uusi-Rauva K , Luiro K , Kopra O , Martinez LO , Tanhuanpaa K , Kalkkinen N , Suomalainen A , Jauhiainen M , Jalanko A
Ref : Hum Mol Genet , 17 :1406 , 2008
PubMedID: 18245779
Gene_locus related to this paper: mouse-ppt

Title : Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1)--distinct characteristics in neurons - Lyly_2007_BMC.Cell.Biol_8_22
Author(s) : Lyly A , von Schantz C , Salonen T , Kopra O , Saarela J , Jauhiainen M , Kyttala A , Jalanko A
Ref : BMC Cell Biol , 8 :22 , 2007
PubMedID: 17565660
Gene_locus related to this paper: mouse-ppt

Title : Gene expression profiling in a mouse model of infantile neuronal ceroid lipofuscinosis reveals upregulation of immediate early genes and mediators of the inflammatory response - Qiao_2007_BMC.Neurosci_8_95
Author(s) : Qiao X , Lu JY , Hofmann SL
Ref : BMC Neurosci , 8 :95 , 2007
PubMedID: 18021406
Gene_locus related to this paper: mouse-ppt

Title : Production of lysophosphatidylcholine by cPLA2 in the brain of mice lacking PPT1 is a signal for phagocyte infiltration - Zhang_2007_Hum.Mol.Genet_16_837
Author(s) : Zhang Z , Lee YC , Kim SJ , Choi MS , Tsai PC , Saha A , Wei H , Xu Y , Xiao YJ , Zhang P , Heffer A , Mukherjee AB
Ref : Hum Mol Genet , 16 :837 , 2007
PubMedID: 17341491
Gene_locus related to this paper: mouse-ppt

Title : Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction - Ahtiainen_2007_Neurobiol.Dis_28_52
Author(s) : Ahtiainen L , Kolikova J , Mutka AL , Luiro K , Gentile M , Ikonen E , Khiroug L , Jalanko A , Kopra O
Ref : Neurobiol Dis , 28 :52 , 2007
PubMedID: 17656100
Gene_locus related to this paper: mouse-ppt

Title : Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in INCL - Zhang_2006_Hum.Mol.Genet_15_337
Author(s) : Zhang Z , Lee YC , Kim SJ , Choi MS , Tsai PC , Xu Y , Xiao YJ , Zhang P , Heffer A , Mukherjee AB
Ref : Hum Mol Genet , 15 :337 , 2006
PubMedID: 16368712
Gene_locus related to this paper: mouse-ppt

Title : Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing - Ahtiainen_2006_Exp.Cell.Res_312_1540
Author(s) : Ahtiainen L , Luiro K , Kauppi M , Tyynela J , Kopra O , Jalanko A
Ref : Experimental Cell Research , 312 :1540 , 2006
PubMedID: 16542649
Gene_locus related to this paper: mouse-ppt

Title : Palmitoyl-protein thioesterase-1 deficiency leads to the activation of caspase-9 and contributes to rapid neurodegeneration in INCL - Kim_2006_Hum.Mol.Genet_15_1580
Author(s) : Kim SJ , Zhang Z , Lee YC , Mukherjee AB
Ref : Hum Mol Genet , 15 :1580 , 2006
PubMedID: 16571600
Gene_locus related to this paper: mouse-ppt

Title : Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice - Virmani_2005_Neurobiol.Dis_20_314
Author(s) : Virmani T , Gupta P , Liu X , Kavalali ET , Hofmann SL
Ref : Neurobiol Dis , 20 :314 , 2005
PubMedID: 16242638
Gene_locus related to this paper: mouse-ppt

Title : AAV2-mediated ocular gene therapy for infantile neuronal ceroid lipofuscinosis - Griffey_2005_Mol.Ther_12_413
Author(s) : Griffey M , Macauley SL , Ogilvie JM , Sands MS
Ref : Mol Ther , 12 :413 , 2005
PubMedID: 15979943
Gene_locus related to this paper: mouse-ppt

Title : Mice with Ppt1Deltaex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons - Jalanko_2005_Neurobiol.Dis_18_226
Author(s) : Jalanko A , Vesa J , Manninen T , von Schantz C , Minye H , Fabritius AL , Salonen T , Rapola J , Gentile M , Kopra O , Peltonen L
Ref : Neurobiol Dis , 18 :226 , 2005
PubMedID: 15649713
Gene_locus related to this paper: mouse-ppt

Title : Pre-sertoli specific gene expression profiling reveals differential expression of Ppt1 and Brd3 genes within the mouse genital ridge at the time of sex determination - Boyer_2004_Biol.Reprod_71_820
Author(s) : Boyer A , Lussier JG , Sinclair AH , McClive PJ , Silversides DW
Ref : Biol Reprod , 71 :820 , 2004
PubMedID: 15128596
Gene_locus related to this paper: mouse-ppt

Title : Early changes in gene expression in two models of Batten disease - Elshatory_2003_FEBS.Lett_538_207
Author(s) : Elshatory Y , Brooks AI , Chattopadhyay S , Curran TM , Gupta P , Ramalingam V , Hofmann SL , Pearce DA
Ref : FEBS Letters , 538 :207 , 2003
PubMedID: 12633880
Gene_locus related to this paper: mouse-ppt

Title : Functional annotation of a full-length mouse cDNA collection - Kawai_2001_Nature_409_685
Author(s) : Kawai J , Shinagawa A , Shibata K , Yoshino M , Itoh M , Ishii Y , Arakawa T , Hara A , Fukunishi Y , Konno H , Adachi J , Fukuda S , Aizawa K , Izawa M , Nishi K , Kiyosawa H , Kondo S , Yamanaka I , Saito T , Okazaki Y , Gojobori T , Bono H , Kasukawa T , Saito R , Kadota K , Matsuda H , Ashburner M , Batalov S , Casavant T , Fleischmann W , Gaasterland T , Gissi C , King B , Kochiwa H , Kuehl P , Lewis S , Matsuo Y , Nikaido I , Pesole G , Quackenbush J , Schriml LM , Staubli F , Suzuki R , Tomita M , Wagner L , Washio T , Sakai K , Okido T , Furuno M , Aono H , Baldarelli R , Barsh G , Blake J , Boffelli D , Bojunga N , Carninci P , de Bonaldo MF , Brownstein MJ , Bult C , Fletcher C , Fujita M , Gariboldi M , Gustincich S , Hill D , Hofmann M , Hume DA , Kamiya M , Lee NH , Lyons P , Marchionni L , Mashima J , Mazzarelli J , Mombaerts P , Nordone P , Ring B , Ringwald M , Rodriguez I , Sakamoto N , Sasaki H , Sato K , Schonbach C , Seya T , Shibata Y , Storch KF , Suzuki H , Toyo-oka K , Wang KH , Weitz C , Whittaker C , Wilming L , Wynshaw-Boris A , Yoshida K , Hasegawa Y , Kawaji H , Kohtsuki S , Hayashizaki Y
Ref : Nature , 409 :685 , 2001
PubMedID: 11217851
Gene_locus related to this paper: mouse-1lipg , mouse-1plip , mouse-1plrp , mouse-ABH15 , mouse-abhd5 , mouse-ABHD6 , mouse-Abhd8 , mouse-aryla , mouse-bphl , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-EPHX1 , mouse-ES10 , mouse-hslip , mouse-hyes , mouse-ABHD2 , mouse-lcat , mouse-lipli , mouse-LIPN , mouse-lypla1 , mouse-lypla2 , mouse-OVCA2 , mouse-pafa , mouse-pcp , mouse-Ppgb , mouse-PPME1 , mouse-ppt , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-Q80UX8 , mouse-RISC , mouse-SERHL , mouse-SPG21 , mouse-Tex30

Title : Mouse palmitoyl protein thioesterase: gene structure and expression of cDNA - Salonen_1998_Genome.Res_8_724
Author(s) : Salonen T , Hellsten E , Horelli-Kuitunen N , Peltonen L , Jalanko A
Ref : Genome Res , 8 :724 , 1998
PubMedID: 9685319
Gene_locus related to this paper: mouse-ppt