| Title : Design, synthesis and evaluation of an uncharged broad spectrum quinoline-oxime hybrid for the reactivation of nerve agent-inhibited human acetylcholinesterase - De Sousa_2026_Eur.J.Med.Chem_316_119023 |
| Author(s) : de Sousa J , Calas AG , De la Mora E , Landry C , Hanak AS , Maryan-Instone A , Gastellier AJ , Coisne C , Courageux C , Hachani J , Gosselet F , Dehouck MP , Rousseau C , Timperley CM , Weik M , Nachon F , Brown RCD , Baati R , Dias J |
| Ref : Eur Journal of Medicinal Chemistry , 316 :119023 , 2026 |
| Abstract : |
| PubMedSearch : De Sousa_2026_Eur.J.Med.Chem_316_119023 |
| PubMedID: 42241775 |
| Gene_locus related to this paper: human-BCHE |
| Title : Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime - Calas_2020_Biomolecules_10_ |
| Author(s) : Calas AG , Hanak AS , Jaffre N , Nervo A , Dias J , Rousseau C , Courageux C , Brazzolotto X , Villa P , Obrecht A , Goossens JF , Landry C , Hachani J , Gosselet F , Dehouck MP , Yerri J , Kliachyna M , Baati R , Nachon F |
| Ref : Biomolecules , 10 : , 2020 |
| Abstract : |
| PubMedSearch : Calas_2020_Biomolecules_10_ |
| PubMedID: 32512884 |
| Title : Chemoselective Hydrogenation of 6-Alkynyl-3-fluoro-2-pyridinaldoximes: Access to First-in-Class 6-Alkyl-3-Fluoro-2-pyridinaldoxime Scaffolds as New Reactivators of Sarin-Inhibited Human Acetylcholinesterase with Increased Blood-Brain Barrier Permeability - Yerri_2020_Chemistry_26_15035 |
| Author(s) : Yerri J , Dias J , Nimmakayala MR , Razafindrainibe F , Courageux C , Gastellier AJ , Jegoux J , Coisne C , Landry C , Gosselet F , Hachani J , Goossens JF , Dehouck MP , Nachon F , Baati R |
| Ref : Chemistry , 26 :15035 , 2020 |
| Abstract : |
| PubMedSearch : Yerri_2020_Chemistry_26_15035 |
| PubMedID: 32633095 |