Jones AL

References (6)

Title : Elevated levels of autoantibodies targeting the M1 muscarinic acetylcholine receptor and neurofilament medium in sera from subgroups of patients with schizophrenia - Jones_2014_J.Neuroimmunol_269_68
Author(s) : Jones AL , Mowry BJ , McLean DE , Mantzioris BX , Pender MP , Greer JM
Ref : Journal of Neuroimmunology , 269 :68 , 2014
Abstract : Schizophrenia is a severe debilitating brain disorder with a poorly understood aetiology. Among the diverse aetiological clues lies evidence for immune abnormalities in some individuals. The aim of this study was to investigate the frequency and specificity of autoantibodies directed against the brain in people with schizophrenia. Sera were screened for reactivity against human brain tissue (hippocampus and prefrontal cortex). Neuronal cell body and filamentous patterns of brain tissue staining were observed significantly more frequently in sera from schizophrenia patients (n=30) compared to controls (n=24). Sera that showed a neuronal cell body pattern of staining on hippocampus reacted strongly to an extracellular epitope of the M1 muscarinic acetylcholine receptor (m1AChR) in ELISA. Both cell body staining and elevated m1AChR reactivity correlated with higher symptom scores for poverty of speech. Sera showing a filamentous staining pattern predominantly targeted microfilaments, intermediate filaments or neurofilaments, particularly neurofilament medium (NFM), which is a dopamine receptor interacting protein. By ELISA, there was strongly elevated reactivity against NFM in a subset (15%) of schizophrenia patients (n=101) compared to healthy controls (n=55) or patients with multiple sclerosis (n=32). These results support the hypothesis that neurotransmitter receptors or molecules involved in regulation of neurotransmission are targets of autoantibodies in some people with schizophrenia.
ESTHER : Jones_2014_J.Neuroimmunol_269_68
PubMedSearch : Jones_2014_J.Neuroimmunol_269_68
PubMedID: 24636402

Title : Comparative genomic analyses reveal a lack of a substantial signature of host adaptation in Rhodococcus equi ('Prescottella equi') - Sangal_2014_Pathog.Dis_71_352
Author(s) : Sangal V , Jones AL , Goodfellow M , Sutcliffe IC , Hoskisson PA
Ref : Pathog Dis , 71 :352 , 2014
Abstract : Rhodococcus equi ('Prescottella equi') is a pathogenic actinomycete primarily infecting horses but has emerged as an opportunistic human pathogen. We have sequenced the genome of the type strain of this species, R. equi strain C7(T) , and compared the genome with that of another foal isolate 103S and of a human isolate ATCC 33707. The R. equi strains are closely related to each other and yet distantly related to other rhodococci and Nocardia brasiliensis. The comparison of gene contents among R. equi strains revealed minor differences that could be associated with host adaptation from foals to humans, including the presence of a paa operon in the human isolate, which is potentially involved in pathogenesis.
ESTHER : Sangal_2014_Pathog.Dis_71_352
PubMedSearch : Sangal_2014_Pathog.Dis_71_352
PubMedID: 24376240
Gene_locus related to this paper: rhoha-e9t397

Title : Prescottia equi gen. nov., comb. nov.: a new home for an old pathogen - Jones_2013_Antonie.Van.Leeuwenhoek_103_655
Author(s) : Jones AL , Sutcliffe IC , Goodfellow M
Ref : Antonie Van Leeuwenhoek , 103 :655 , 2013
Abstract : The taxonomic status of Rhodococcus equi, originally isolated from foal specimens, has been the subject of discussion for a number of years. The chequered history of the taxon has prompted this polyphasic analysis of R. equi strains, close members of the genus Rhodococcus and representatives of other genera classified in the order Corynebacteriales, to establish the taxonomic position of this taxon. Thirty one R. equi strains, including the type strain, were examined for genotypic and numerical taxonomic properties. The resultant data are consistent with their classification in the order Corynebacteriales but the R. equi strains formed a distinct phyletic clade away from representatives of other members of the genus Rhodococcus in the 16S rRNA gene tree. Representatives of this clade shared their highest pairwise 16S rRNA gene sequence similarities with the type strain of Rhodococcus kunmingensis (95.2-98.1 %). However, the R. equi taxon was readily distinguished from R. kunmingensis and from the other members of the order Corynebacteriales using a combination of genotypic, chemotypic and phenotypic properties. On the basis of these data the R. equi strains are considered to represent a new genus. The name proposed for this taxon is Prescottia gen. nov., with Prescottia equi comb. nov. as the type species containing the type strain, C 7(T) (= ATCC 25729(T) = ATCC 6939(T) = CCUG 892(T) = CIP 54.72(T) = DSM 20307(T) = HAMBI 2061(T) = NBRC 14956(T) = JCM 1311(T) = JCM 3209(T) = LMG 18452(T) = NBRC 101255(T) = NCTC 1621(T) = NRRL B-16538(T) = VKM Ac-953(T)).
ESTHER : Jones_2013_Antonie.Van.Leeuwenhoek_103_655
PubMedSearch : Jones_2013_Antonie.Van.Leeuwenhoek_103_655
PubMedID: 23161262
Gene_locus related to this paper: coreq-e9sxw6 , coreq-e9t5k8 , coreq-e9t5k9 , coreq-e9t7v9 , rhoha-e9t397 , coreq-e9swc5 , rhoe1-e4wix8 , rhoe1-e4wjy1

Title : Fluostatins C-E, novel members of the fluostatin family produced by Streptomyces strain Acta 1383 - Baur_2006_J.Antibiot.(Tokyo)_59_293
Author(s) : Baur S , Niehaus J , Karagouni AD , Katsifas EA , Chalkou K , Meintanis C , Jones AL , Goodfellow M , Ward AC , Beil W , Schneider K , Sussmuth RD , Fiedler HP
Ref : J Antibiot (Tokyo) , 59 :293 , 2006
Abstract : Three new members of the fluostatin family, fluostatins C-E, were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptomyces and is closely related to type strains classified in the Streptomyces lavendulae 16S rRNA subclade. Fluostatins are named by their characteristic fluorenone chromophore. Fluostatin C shows moderate activity against selected human tumor cell lines.
ESTHER : Baur_2006_J.Antibiot.(Tokyo)_59_293
PubMedSearch : Baur_2006_J.Antibiot.(Tokyo)_59_293
PubMedID: 16883779

Title : Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial pan-genome - Tettelin_2005_Proc.Natl.Acad.Sci.U.S.A_102_13950
Author(s) : Tettelin H , Masignani V , Cieslewicz MJ , Donati C , Medini D , Ward NL , Angiuoli SV , Crabtree J , Jones AL , Durkin AS , DeBoy RT , Davidsen TM , Mora M , Scarselli M , Margarit y Ros I , Peterson JD , Hauser CR , Sundaram JP , Nelson WC , Madupu R , Brinkac LM , Dodson RJ , Rosovitz MJ , Sullivan SA , Daugherty SC , Haft DH , Selengut J , Gwinn ML , Zhou L , Zafar N , Khouri H , Radune D , Dimitrov G , Watkins K , O'Connor KJ , Smith S , Utterback TR , White O , Rubens CE , Grandi G , Madoff LC , Kasper DL , Telford JL , Wessels MR , Rappuoli R , Fraser CM
Ref : Proc Natl Acad Sci U S A , 102 :13950 , 2005
Abstract : The development of efficient and inexpensive genome sequencing methods has revolutionized the study of human bacterial pathogens and improved vaccine design. Unfortunately, the sequence of a single genome does not reflect how genetic variability drives pathogenesis within a bacterial species and also limits genome-wide screens for vaccine candidates or for antimicrobial targets. We have generated the genomic sequence of six strains representing the five major disease-causing serotypes of Streptococcus agalactiae, the main cause of neonatal infection in humans. Analysis of these genomes and those available in databases showed that the S. agalactiae species can be described by a pan-genome consisting of a core genome shared by all isolates, accounting for approximately 80% of any single genome, plus a dispensable genome consisting of partially shared and strain-specific genes. Mathematical extrapolation of the data suggests that the gene reservoir available for inclusion in the S. agalactiae pan-genome is vast and that unique genes will continue to be identified even after sequencing hundreds of genomes.
ESTHER : Tettelin_2005_Proc.Natl.Acad.Sci.U.S.A_102_13950
PubMedSearch : Tettelin_2005_Proc.Natl.Acad.Sci.U.S.A_102_13950
PubMedID: 16172379
Gene_locus related to this paper: strag-ESTA , strag-GBS0040 , strag-GBS0107 , strag-GBS1828 , strag-pepx , strag-q3dah6 , strag-SAG0246 , strag-SAG0383 , strag-SAG0679 , strag-SAG0680 , strag-SAG0785 , strag-SAG0912 , strag-SAG1562 , strag-SAG2132

Title : The features and management of poisoning with drugs used to treat Parkinson's disease -
Author(s) : Jones AL , Proudfoot AT
Ref : Qjm , 90 :613 , 1997
PubMedID: 9415342